The Web Health



Generic name: Pegloticase [ peg-LOE’ti-kase Peg-LOE-ti-kase
The Brand Name is Krystexxa.
Dosage Format: Intravenous solution (8 mg/mL)
Drug Class: Antihyperuricemic agents

What is Pegloticase?

Pegloticase is a treatment for chronic gout. Pegloticase is typically prescribed after other gout medicines have been tried but with no success in curing the symptoms.

Pegloticase is also employed for other purposes that are not covered in this guideline for medication.

Side effects of Pegloticase

See a doctor immediately. If you are experiencing symptoms that are warning signs of an allergic response, like hives, trouble breathing, and swelling of your lips, face, and tongue,

There are some side effects that can happen after the injection. Contact your physician if you are feeling nervous, lightheaded, itchy, shaky, having rapid heartbeats, chest pain, or a redness on your skin after the injection.

Pegloticase may cause serious side effects. Contact your physician immediately in the event that you experience:

  • Chest pain,
  • Flushing (the warmth of redness or a tingly sensation).

Common negative side effects of pegloticase include:

  • COVID-19 symptoms include chills or fever, cough or sore throat, tiredness, shortness of breath, muscular or body aches, and loss of smell or taste.
  • Hives, breathlessness tension or discomfort in the chest; redness of the skin; the sensation of itching;
  • Joint pain;
  • Allergies;
  • New gout flares for the gout;
  • Nausea, vomiting, constipation,

It isn't a complete list of the possible consequences, but other effects may occur. Consult your physician for medical advice regarding adverse reactions. It is possible to report any adverse negative effects to the FDA by dialing 1-800-FDA-1088.


Inform your doctor about your current medications and all the ones you begin or stop taking. A variety of drugs interact, and certain drugs shouldn't be taken together.

Inform your healthcare provider immediately if you are irritable, lightheaded, tired, or feel chest pain or skin redness after the injection.

Before you take this drug

It is not recommended to use pegloticase when you have an allergy to it or suffer from a genetically related enzyme defect known as glucose-6-phosphate dehydrogenase (G6PD) deficiency.

Certain medicines may cause undesirable or hazardous effects when they are combined with pegloticase. Your doctor could alter the treatment plan in the event that you use any of the following:

  • Allopurinol (Zyloprim);
  • Febuxostat (Uloric).

Speak to your doctor if you are ever diagnosed with:

  • Heart conditions

It isn't known if pegloticase can harm an unborn baby. Inform your doctor if you are expecting or plan to be pregnant.It might not be safe to breastfeed while using this medication. Consult your physician regarding any risks.

How to take Pegloticase?

Pegloticase can be given in the form of an infusion into a vein, typically every two weeks. Your healthcare provider will offer the injection.The medication must be administered slowly, and the infusion may last for at least two hours.

There are other medications to avoid severe reactions or allergic reactions. Your doctor could also suggest different gout medicines to take for the first six months of treatment using pegloticase. Continue to take all medications for as long as your physician prescribes them.

If you are the first to start pegloticase, you could notice an increase in the number of flares of gout.Your doctor will monitor your health regularly.Inform your doctor if symptoms don't improve after three months.

Details on dosage

Usual Adult Dose for Gout:

8 mg via IV infusion every 2 weeks
It must be administered via IV infusion (over at least 120 minutes). Don't administer an IV push, bolus, or
Premedications (e.g., antihistamines, corticosteroids) are recommended to lower the chance of allergic reactions or infusion-related reactions.
This drug is not suggested to treat hyperuricemia that is not symptomatic.
The ideal time for treatment hasn't been determined.
Use: To treat chronic gout among patients who are resistant to treatment with conventional methods (e.g., patients who have not been able to restore normal levels of serum uric acids and whose symptoms are not adequately managed with xanthine oxidase inhibitors at the highest dosage medically appropriate or in those who are not suitable for these medications).

What happens if I miss a dose?

Contact your doctor for advice in the event that you don't make an appointment for the pegloticase injection.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

Follow your doctor's advice regarding any limitations on foods, drinks, or activities.

Interaction with other drugs

Other drugs can also influence pegloticase, such as medications that are prescribed and available over the counter, vitamins, and herbal products. Inform your physician about the medicines you are currently taking as well as any medications you are about to start or stop taking.