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Generic Name: Panobinostat [PAN-oh-BIN-oh-stat]
Name of the Brand: Farydak
Dosage Form: Oral capsule (10 mg; 20 mg)
The class of Drugs: Histone deacetylase inhibitors

What is Panobinostat?

Panobinostat is used in conjunction with other medications in order to manage the condition of multiple myeloma in adults who have had at least two different types of treatment.

Panobinostat can also be used for reasons not mentioned in this medication guide.

Side effects of Panobinostat

Contact a medical professional immediately. Get medical attention immediately if you notice symptoms that indicate an allergic reaction, such as difficulty breathing, hives, or swelling of your lips, face, or tongue.

Panobinostat could cause fatal or severe heart issues. Get medical attention in the event of:

  • Chest pain, rapid or slow heartbeats
  • Dizziness, or feeling like you might pass out;
  • Blue-colored lips;
  • Swelling in your lower legs;

Panobinostat can cause serious adverse effects. Consult your doctor immediately if you experience:

  • Persistent or severe diarrhea, as well as stomach cramps that persist;
  • Bleeding or bruising, the bleeding will not stop;
  • Symptoms of bleeding within the body: headache dizziness, headache, and confusion symptoms of bleeding inside your body: dizziness, headache, confusion; brown or pink urine, bloody or tarry stool, coughing up the blood or vomit looks like coffee grounds
  • Low red blood cells (anemia)—pale skin, feeling lightheaded or short of breath, cold hands and feet;
  • Symptoms of signs of infection signs of infection: fever symptoms include chills, fever, sweating, difficulty breathing, a cough with mucus, skin sores, and feeling tired and exhausted;
  • Dehydration symptoms: feeling very hot or thirsty; feeling not able to urinate; sweating heavily; having dry and hot skin;
  • Problems with the liver: loss of appetite, stomach discomfort (upper right aspect) dark urine, and jaundice (yellowing of the eyes or skin).

Common adverse effects of panobinostat could include:

  • Vomiting, vomiting, and loss of appetite.
  • Fever
  • Swelling of your legs or arms.

This isn't an exhaustive listing of all negative side consequences. There are other effects that could be observed. Talk to your doctor and seek medical advice about the symptoms. If you have any concerns, report them to the FDA by calling 1-800-FDA-1088.


Panobinostat may cause fatal or serious heart issues. Get medical attention in the event of chest pain, rapid or slow heartbeats, dizziness or fainting, swelling of your feet, lips that are blue, or a shortness of breath.

Consult your physician. If you experience severe stomach cramps or diarrhea, or if you become thirsty (increased thirst, less frequent sweating, dry and hot skin).

Inform your doctor immediately. If you experience bleeding that isn't stopping, stop. This could include blood in your stool or urine, dizziness, confusion, bleeding from your bowels, or vomiting blood.

Before you take this drug

Consult your physician if you're suffering from diarrhea or if you've ever:

  • Heart issues, like long QT syndrome;
  • Any kind of infection;
  • Bleeding issues as well as
  • Liver disease.

Panobinostat may cause harm to an unborn baby when the father or mother is taking it.

  • If you're female, you may need to undergo a pregnancy test prior to beginning this treatment. Utilize effective contraception to avoid pregnancy while using this medication and for at least three months following your last dose.
  • If you're male, use effective birth control when your partner can get pregnant. Use birth control for a minimum of six months following your last dose.
  • Contact your physician immediately. If you become pregnant when one of the mothers or fathers is taking panobinostat,

It is not recommended to breastfeed while using this medicine.

Panobinostat has not been approved for use by anyone less than 18 years of age.

How To Take Panobinostat?

Follow the directions on the label of your prescription and read the medication guide or instructions sheets. The doctor might alter your dosage. Be sure to take your dosage exactly as directed.

Panobinostat is usually prescribed three times a week until your doctor advises you to stop taking the drug.Take a drink of fluid at any time, whether or not you are eating.

Consume the capsule in its entirety and don't chew, crush, open, or break it. Don't use the capsule that is broken. If the medicine in broken pills gets into your eyes or gets on your skin, cleanse your face using soap and water. You can also cleanse your eyes with water.

If you experience vomiting shortly after taking panobinostat, do not take a different capsule. Your next dose must be taken in the same way as you normally would.

Panobinostat can cause severe diarrhea or dehydration. There are medications available to prevent diarrhea and other adverse effects. You should take these medications for as long as your physician prescribes them.You'll need to undergo frequent medical exams, and treatment could be delayed based on the results.

Keep the blister pack in the carton in the original container in a cool, dry place away from heat, moisture, and light. Take a capsule out only once you're ready to consume it.

Details on dosage

Usual Adult Dose for Multiple Myeloma:

Initial dosage: 20 mg taken orally, once a day, for three doses per week (on days 1, 3, 5, 8, 10, and 12) between Weeks 1 and 2 in each 21-day cycle.
Time of treatment: up to the 16th cycle (48 weeks).
It is recommended to continue treatment with this medication for a further eight cycles (16 cycles in total) for patients who show clinical benefit but don't have unresolved medically significant toxicities.
This drug is used together with the drugs bortezomib and dexamethasone. Refer to the product's manufacturer to determine the recommended dosage for these two medications.
Treatment for patients suffering from multiple myeloma who have received at least two prior treatments, including Bortezomib as well as an immunomodulatory agent

What happens If I miss a dose?

Utilize the medicine as quickly as you can. However, avoid your missed dose if you have been more than twelve hours behind on the dose. Don't take two doses at once.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help line toll-free at 1-800-222-1222.

What should be avoided?

Certain foods can interfere with panobinostat, causing adverse consequences. Avoid eating star fruit like pomegranate, grapefruit, and pomegranate products while taking panobinostat.

Do not use a laxative or stool softener. They could cause diarrhea to worsen.

Interaction with other drugs

Panobinostat can trigger a serious heart condition. The risk is greater if you are also taking various other medications for asthma, infections, and heart conditions, as well as high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Other medications may interact with panobinostat as well, such as prescription or OTC medicines, vitamins, and herbal products. Inform your physician about all the medications you currently use and any medications you begin or stop taking.



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