What is Panitumumab?
Panitumumab is utilized to treat a particular kind of metastatic colorectal cancer that has increased in size following the treatment of other cancers.
Panitumumab can only be used in cases where the tumor is a wild-type RAS tumor, for which your physician will perform a biopsy.Panitumumab can also be employed for other purposes that are not covered in this medication guide.
Side effects of Panitumumab
See a doctor immediately. Get medical attention immediately if you notice symptoms that are warning signs of an allergic response, like hives, trouble breathing, and swelling of your lips, face, or tongue.
Certain side effects can occur when you inject. Inform your doctor immediately if you experience dizziness or nausea, feel lightheaded, chills, or feverishness, or feel chest tightness or difficulty breathing.
You should seek medical care at the first sign of a rash on your skin. Panitumumab may cause severe skin issues that could result in extensive infections and even death.
Panitumumab may cause serious side effects. Contact your physician immediately if you experience:
- Persistent or severe diarrhea;
- A sudden sensation of discomfort in the chest, wheezing, a dry cough or hacking sensation, or being out of breath;
- Swelling, redness, or irritation in your eyelids or eyelids;
- Facial swelling;
- Lower potassium level, causing leg muscle cramps constipation, irregular heartbeats, fluttering of your chest, thirst, or increased urine Tingling or numbness in muscles; muscles becoming weak or limp;
- Dehydration symptoms: feeling extremely thirsty, hot, or sweaty and not being able to urinate; excessive sweating; or dry and hot skin;
- Symptoms of kidney problems: little or no urination, difficult or painful urination, swelling on your ankles or feet, feeling exhausted or weak,
- Skin problems—severe or more severe acne, swelling, or infection on your fingernails and toenails—and the skin may exhibit itching, dryness, redness, cracking, peeling, or bleeding.
It is possible that your cancer treatments could be delayed or completely stopped when you experience certain negative side effects.
Common side effects of panitumumab include:
- Dry skin, acne, itching, itching
- The swelling or irritation that occurs around your fingernails and toenails
- Loss of appetite dizziness loss of appetite, vomiting;
- The appearance of blisters or ulcers inside your mouth; swelling or red gums; difficulty swallowing;
- Fatigue, weakness,
- Low potassium.
This is not an exhaustive listing of all negative side negative effects. Other scenarios could occur. Ask your doctor advice from a medical professional regarding any adverse effects. If you have any concerns, report them to the FDA by calling 1-800-FDA-1088.
Warnings
Panitumumab can cause serious skin conditions that could cause an extensive infection and even death. Get medical attention immediately if you notice any itchy skin rash.
Before you take this drug
Panitumumab is not a good option if you have an allergy to it.
Speak to your doctor if you have ever suffered from:
- Lung disease, breathing problems;
- An inflammation of your cornea (keratitis) an eye ulcer (keratitis)
- An electrical imbalance (such as low magnesium, calcium, and potassium levels in the blood).
Panitumumab can cause harm to a baby who is not yet born. Use effective birth control to avoid pregnancy while taking panitumumab for at least two months following the last dose. Inform your doctor in the event that you discover you are pregnant.
You might experience an irregular menstrual cycle when you are taking panitumumab.Breastfeeding is not advised during treatment with panitumumab.
How to take Panitumumab?
Your doctor could conduct a biopsy to be sure that panitumumab is the correct treatment for the cancer you have.Panitumumab is administered as an injection into the vein. The healthcare professional will offer the injection.
Panitumumab should be administered slowly. The infusion could take as long as 90 minutes to finish.Panitumumab is usually administered twice a week. Follow your doctor's prescriptions.
Consult your physician if you are suffering from persistent nausea and diarrhea. Also, tell your doctor if you are sweating more frequently than usual. You could easily become dehydrated when using panitumumab. This could lead to high blood pressure, electrolyte imbalances, or kidney failure.
There is a chance that you'll need to have regular blood tests. Your eyes and skin might also require examination.Panitumumab may be long-lastingly harmful to the body. You may need frequent medical tests for as long as 8 weeks after the last time you took this medication.
Details on dosage
Usual Adult Dose for Colorectal Cancer:
6 mg/kg IV for 60 minutes each day for 14 days If the first infusion is well tolerated, the next infusions are administered over 30 to 60 minutes. Give doses greater than 1000 mg in 90 minutes.
Comments:
Before beginning treatment, evaluate the RAS mutational status of colorectal tumors. confirm that there is no RAS gene mutation within exon 2 (codons 12 and 13), exon 3 (codons 59 and 61), and exon 4 (codons 117 and 146) in each of KRAS as well as NRAS.
See Dose Adjustments for dosage adjustments for patients who experience reactions to infusions or toxic dermatologic reactions.
Uses: To treat RAS with wild-type (defined as wild-type both in KRAS and NRAS, as established through an FDA-approved test for this usage) metastatic colorectal tumor (mCRC):
in conjunction with FOLFOX for treatment in the first line.
as monotherapy following disease progression after prior treatment with fluoropyrimidine, oxaliplatin, and irinotecan-containing chemotherapy.
What happens if I miss the dose?
Contact your doctor for advice in the event that you don't make an appointment for the panitumumab injection.
What happens if I overdose?
Get medical attention in an emergency or contact the Poison Help line toll-free at 1-800-222-1222.
What should be avoided?
Avoid exposure to the sun as well as tanning beds. Panitumumab could cause the skin to burn more quickly. Protect yourself with protective clothes and wear sunblock (SPF 30 or more) throughout treatment and for at least two months following the time you stop receiving panitumumab.
Interaction with other drugs
Other drugs can interact with panitumumab's effects, including prescription and non-prescription medicines, vitamins, and herbal products. Discuss with your physician all the medications you currently use as well as any medications you are about to start or stop taking.
