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Generic Name: Palifermin
The Brand Name is Kepivance.
Dosage Format: Intravenous powder for injection (6.25 mg)
Classification of Drugs: Miscellaneous uncategorized agents

What is Palifermin?

Palifermin can be used to stop or heal mouth ulcers and mouth sores in patients receiving stem cell therapy and chemotherapy.

Palifermin can be found in patients who are receiving chemotherapy for blood cancers (Hodgkin's disease, multiple myeloma, and leukemia). Palifermin isn't a treatment for leukemia as such.Palifermin can also be employed for other purposes that are not covered in this medication guide.

Side effects of Palifermin

See a doctor immediately. If you are experiencing symptoms that indicate an allergic reaction, such as hives, difficulty breathing, and swelling of your lips, face, and tongue,

Palifermin could cause severe adverse reactions. Contact your physician immediately if you experience:

  • Blurred vision, blurred vision, tunnel vision, eye pain, or seeing halos of light.

Common negative effects of palifermin include:

  • Fever;
  • Redness or swelling on your skin.
  • Itching, itching, or Itching or rash
  • An abnormal blood test.

It's not a comprehensive description of the various negative results. The risk of other adverse side effects is also possible. Consult your doctor for medical advice about the side effects. It is possible to report any adverse allergic reactions or symptoms to FDA by calling 1-800-FDA-1088.


Follow all the instructions on the label of your medication and on the label of your package. Be sure to inform your healthcare professionals about your medical issues, allergies, and the medicines you are taking.

Before you take this drug

It is not recommended to use palifermin if you have an allergy to it.Palifermin can cause the growth of tumors not connected to blood cancer. Discuss this with your doctor in the event that you have a history of any kind of cancer.Palifermin could cause harm to a baby who is not yet born. Use effective birth control to stop pregnancy and inform your doctor if you're pregnant.

Palifermin could alter fertility (your potential to bear children) regardless of whether you're either male or female.Avoid breastfeeding while taking this medication and for at least two weeks following the last dose.Palifermin is not a product that has been approved for use by children younger than one year old.

How to take Palifermin?

Palifermin is administered as an injection into the vein. Your healthcare professional will administer this injection prior to and following chemotherapy treatment.

The injections of palifermin are scheduled to occur at specific intervals in your treatment. Follow your doctor's directions on when to take each injection.Palifermin should not be administered within 24 hours prior to the time you will receive the chemotherapy.

Details on dosage

Usual Adult Dose for Mucositis:

60 mg/kg IV (as a dose in a bolus) every day, given for 3 consecutive days prior to and for 3 consecutive days after myelotoxic treatment.
Prior to starting myelotoxic therapy, the third dose is to be administered 24 to 48 hours before starting the myelotoxic drug.
Following myelotoxic therapy The first dose should be given on the day of the infusion of hematopoietic stem cells after the infusion is completed and at least 7 days following the last dose of this drug.
Reduce the incidence of and length of severe mouth mucositis in patients with cancers of the hematology receiving myelotoxic treatment as part of autologous hematopoietic stem-cell support.
Supportive care for regimens that are predicted to cause more than or the same as WHO Mucositis Grade 3 with the greatest proportion of patients

What happens if I miss the dose?

Consult your physician for the proper procedure in the event that you don't make an appointment to receive your injection with palifermin.

What happens If I overdose

Because palifermin is administered by a health specialist in a medical setting, it is highly unlikely for an overdose to occur.

What should be avoided?

Follow the instructions of your physician regarding food, beverages, foods, or activities.

Interaction with other drugs

Other drugs can also affect palifermin, such as medications that are prescribed and available over the counter, vitamins, and herbal products. Discuss with your doctor all the medicines you are currently taking as well as any medicines you are about to start or stop taking.