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Generic name: benzoyl peroxide and clindamycin topical [BEN-zoyl-per-OX-ide-and-clin-da-MYE-sin]
Names of brands: Acanya, Neuac, Onexton, Z-Clinz 10, DUAC, Z-Clinz 5.
Drug class: Topical acne agent

What is Onexton?

Benzoyl peroxide is antibacterial and has anti-microbial properties. Also, it has a slight drying effect that allows the excess dirt and oil to be removed. Clindamycin can be described as an antibiotic that stops bacteria from developing within the body. Onexton (for your surface) is a combination medicine for treating acne. Onexton can also be used to treat conditions not covered in this medication guide.

Side effects of Onexton

Benzoyl peroxide may cause an uncommon but severe allergic reaction to the skin or cause severe irritation. These reactions could occur only an hour after applying the medication and may last for a few days or more afterward.

Take a break from Onexton and seek medical emergency assistance if you are experiencing symptoms or warning signs of an allergic response such as itching, hives itching or burning sensations, difficulty breathing, or feeling lightheaded or swollen cheeks, mouth, lips, tongue, or throat.

This medication can cause severe adverse reactions. Take this medicine off and contact your doctor immediately if you suffer from:

  • Intense redness, burning, peeling, or stinging of the skin-treated areas; or
  • Diarrhea that is either watery or bloody.

Common adverse effects of onexton could include:

  • Slight burning or stinging
  • The sensation of itching or tingling;
  • Dryness, peeling, or flaking of the treated skin or
  • The redness or irritation could be caused by other factors.

This isn't a complete list of possible side effects, and other side effects could occur. Contact your physician for advice regarding medical effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.


This medicine may cause an uncommon but serious allergic reaction or severe itching on the skin. Stop using this medicine immediately and seek medical attention if you experience symptoms like itching, hives, trouble breathing, feeling lightheaded, or swelling of your lips, face, tongue, throat, or face.

Before you take this drug

You shouldn't make use of Onexton if you have an allergy to benzoyl peroxide or clindamycin (Cleocin, Clina-Derm, Clindets).

Even though this drug can be applied directly to your skin, the body can absorb enough clindamycin to trigger severe adverse consequences. It is possible that you will not be able to take this drug if you suffer from:

  • Inflammation of the intestinal tract (also known as enteritis)
  • Ulcerative colitis or
  • If you've ever experienced severe diarrhea due to antibiotic medication,

It isn't known if Onexton could harm an unborn baby. Consult your physician if you are pregnant or planning to become pregnant while taking Onexton.

It isn't known if benzoyl peroxide and Clindamycin are absorbed into breast milk or the risk to the nursing infant. Do not breastfeed when taking this medication.

How to take Onexton?

Follow the instructions on the prescription label. Don't use this medication in greater or lesser quantities or for longer periods than prescribed. Applying more medication or using it more often than the prescribed amount won't help it work quicker and could result in more adverse negative effects.

Benzoyl peroxide could cause a rare but serious allergic reaction or severe skin inflammation. Before you start taking this medication, it is possible to apply an initial "test dose" to see whether you are experiencing reactions. Apply a tiny amount of the drug to one or two small spots of acne each day for three days. If there's no reaction, you can begin applying the full amount prescribed on the fourth day. Wash your hands thoroughly prior to and after applying the medicine. Cleanse your face with a mild cleansing agent (not soap) and gently pat the face dry using a clean towel. Onexton is generally applied twice daily, both in the morning and at night.

Be careful not to get this medication in your mouth, eyes, or nose (or within the creases of your nose), as well as on your lips. If it gets into one of these places, rinse with water. Avoid applying this medication to sunburned, windburned, chapped, dry, irritated, or broken skin.

It could take several weeks before you notice improvement in your symptoms. Use the medication exactly according to instructions, and notify your physician if your symptoms don't improve. If you get more than one bottle of Acanya and Duac Gel, store the sealed container in a fridge when you're ready to begin using it. Don't freeze it. After use After use, store it at room temperature, away from heat and moisture. Don't put it in the freezer. Get rid of any medicine you haven't used by the end date on the prescription label. Duac comes with an expiration time of sixty days. Acanya is expiring in 10 weeks. BenzaClin is due to expire in three months.

What happens if I miss the dose?

Take the dose you missed immediately after you remember. Do not take any missed doses if it's nearing the time for the next dose. Don't take extra medicine to make up for the missed dose.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help Line toll-free at 1-800-222-1222. In the case of an overdose, symptoms may be characterized by watery or bloody diarrhea. This can happen when you absorb Onexton by rubbing it on your skin and applying excessive amounts.

What should be avoided?

Avoid using products for your skin that can cause irritation, like harsh shampoos, soaps, skin cleansers, hair coloring chemicals, hair removers, and waxes, as well as skin products that contain alcohol, spices, lime, or astringents. Beware of other medications that affect the areas that you treat using Onexton unless your medical professional instructs you to.

Diarrhea can be caused by antibiotics and could be an indication of a new disease. If you experience diarrhea that is bloody or watery and bloody, stop taking Onexton and contact your doctor. Don't take anti-diarrhea medication unless your doctor advises you to. Avoid exposure to the sun and tanning beds. The medication may cause more sunburn more quickly. Be sure to wear protective attire and sunblock (SPF 30 or more) whenever you're outside.

Do not apply sunscreens containing PABA to the skin that has been treated with Onexton, or skin discoloration could be observed. The peroxide benzoyl can bleach hair and fabrics. Be sure not to let this drug come into contact with hair, clothing, colored towels, or bedding linens.

Interaction with other drug

It is unlikely that any other medication that you consume or inject can affect the benzoyl peroxide that you apply topically or the clindamycin. However, many medications can interact with each other. Be sure to inform your health professionals about the medicines you use, such as prescription and over-the-counter medications, vitamins, and herbal remedies.