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Name of Generic: Phenylephrine ophthalmic (also known as fen-ill-EFF rin)
The Brand Names are: AK-Dilate, Altafrin, Mydfrin, Neofrin, and Mydfrin.
Classes of Drugs: Mydriatics, ophthalmic antihistamines, and decongestants

What is Neofrin?

Phenylephrine Phenylephrine is a decongestant that shrinks blood vessels.Neofrin (for the eyes) is a medication used to treat the redness, burning, dryness, and irritation of the eyes caused by the sun, wind, and other irritating factors.Neofrin is also employed for reasons not mentioned in this guideline.

Side effects of Neofrin

Contact a medical professional immediately. If you experience any of the following symptoms as warning signs of an allergic reaction: hives, trouble breathing, and swelling of your lips, face, and tongue,

Although the chance of having adverse side effects is minimal when Neofrin is administered to the eyes, adverse reactions could occur if the drug is absorbed into the bloodstream. Stop taking this medication and consult your physician immediately if you experience:

  • Heart rate that is irregular or fast;
  • Sweating, tremors;
  • Pale skin, a lightheaded feeling;
  • Extreme headache that causes a buzzing sensation within your ears anxiety, breathing problems severe headache, buzzing in your ears, anxiety, shortness of breath
  • Chest discomfort or pressure that is spreading into your shoulder or jaw.

More minor side effects might be more likely, and you could not experience any whatsoever.

There isn't an exhaustive listing of the various negative consequences. Other effects may also be present. Consult your physician to seek medical advice on the effects. You can report any side effects to the FDA at 1-800-FDA-1088.


Neofrin is not recommended for glaucoma with narrow angles.

Before you take this drug

It is not recommended to take Neofrin if you are allergic to it or if you suffer from narrow-angle glaucoma.

Don't use Neofrin without the advice of a physician. If you suffer from:

  • An eye infection;
  • An eye injury;
  • If you've recently undergone eye surgery.

Any of these conditions could cause your eyes to absorb Neofrin from your body, which can have harmful effects on the heart.

Speak with a physician or pharmacist about whether it is safe to take Neofrin if you suffer from other medical conditions, particularly:

  • High blood pressure;
  • Any heart condition of any kind;
  • Coronary artery diseases (hardening the arteries)
  • Asthma or sulfite allergies.

FDA classification for pregnancy C It is not clear whether Neofrin could cause harm to a baby who is not yet born. Inform your doctor if you are pregnant or plan to become pregnant while taking the medication.It is unclear if the ophthalmic phenylephrine gets into breast milk or whether it is harmful to the nursing infant. Inform your doctor if you are breastfeeding a child.

Avoid giving this medication to a child unless you have medical guidance.

How to take Neofrin?

Follow the directions on the label or as recommended by your physician. Avoid using in larger quantities, in smaller quantities, or for a longer time than is recommended.

Wash your hands thoroughly prior to applying drops to your eyes.

To apply drops to the eyes:

  • Turn your head slightly back and then pull your lower eyelids to create an eyelid pocket. Keep the dropper in front of your eye with the tips towards the lower. Take a look at the sky and then away from your dropper, and squeeze the drop.
  • Keep your eyes closed for 2 to 3 minutes with your head tilted down without blinking or squinting. Press your finger gently against the inside of your eye for two to three minutes to prevent the liquid from leaking into the tear duct.
  • Make sure you only use the number of drops that your doctor prescribed or as directed on the medication label. If you take several drops at once, you should wait at least 5 minutes between drops.
  • At least 10 minutes prior to using any eye drop or other product that your medical professional has advised you to use.

Don't touch the tip of your eyedropper or put it directly in your eyes. Drops that are contaminated can affect your eyes and could result in severe vision issues.

Don't use eye drops if it appears that the liquid is changing colors or contains particles. Consult your pharmacist about the latest medication.Your blood pressure could require checking during the time you take Neofrin.Do not take this medication for more than 3 days. Consult your doctor if symptoms do not improve or if they become worse after using Neofrin.

The long-term use of phenylephrine as an ophthalmic agent could cause damage to blood vessels (veins and arteries) within the eyes.Keep the bottle at room temperature, free of heat, moisture, and light. Make sure the bottle is tightly shut when not in use.

What happens If I miss a dose?

Do the missed dose when you remember. Don't miss your missed dosage if you are nearing the time to take the next dose. Don't take extra medication to replace the missed dose.

What happens If I overdose?

A dose of Neofrin that is overdosed isn't expected to pose a risk. Get medical attention immediately or contact the Poison Help line at 1-800-222-1222 in the event that someone has accidentally swallowed the drug.

What should be avoided?

Don't use Neofrin if you wear contact lenses. Neofrin could contain a preservative that can alter the color of contact lenses. Make sure to wait for at least 15 minutes following the use of this medication before inserting the contact lens.

This medication can cause blurred vision and could affect your reaction. Be cautious if you drive or engage in any activity that requires you to see clearly.

Interaction with other drugs

Discuss with your physician if you have taken an MAO inhibitor in the last 21 days. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, rasagiline, and phenelzine, as well as tranylcypromine and others.

Other medications can interfere with phenylephrine eye drops, including prescription and over-the-counter medicine, vitamins, and herbal products. Inform your health professionals about the medicines you are taking now and any medication you stop or start using.