What is Naldemedine?
Naldemedine decreases constipation caused by opioid pain medications that are used to treat severe chronic pain.
Naldemedine is intended for those who take opioid pain medication to combat chronic pain not caused by cancer.Naldemedine is also used for reasons not mentioned in this guideline.
Side effects of Naldemedine
Contact a medical professional immediately. If you are experiencing symptoms that indicate an allergic reaction, like hives, trouble breathing, or swelling of your lips, face, and throat,
Inform your doctor if you notice signs of withdrawal from opioids like fever, sweating, chills, sensations of warmth or tingling on the face or body, shaking or rapid heartbeats, feeling nervous or stressed, yawning, nasal congestion, sneezing, eye watering, stomach pain, nausea, vomiting, and diarrhoea.
Naldemedine may cause serious side effects. Stop taking naldemedine and consult your physician immediately. If you suffer from:
- Severe diarrhoea;
- Extreme stomach pain that does not go away (this could be a sign of serious medical issues).
Common adverse effects of naldemedine could include:
- Nausea, vomiting, stomach pain,
- Diarrhoea.
This is not a comprehensive list of all the side effects. Other side effects could be present. Consult your physician to seek medical advice on adverse effects. You can report adverse reactions to the FDA at 1-800-FDA-1088.
Warnings
It is not recommended to use naldemedine in the event of an obstruction in your stomach or intestines.
Stop taking naldemedine and contact your doctor right away if you are experiencing severe stomach pain that doesn't go away (this could lead to serious medical issues).
Inform your doctor when you experience signs of withdrawal from opioids, including sweating at night, feeling cold or hot, a feeling of being cold and tremors, quick beating heartbeats, anxiety, eyes that are watery, a runny nose, vomiting, or diarrhoea.
Before you Take this Drug
Naldemedine should not be used if you have an allergy to this substance or suffer from:
- An obstruction in your stomach or the intestines.
Inform your doctor if you have ever suffered from:
- A stomach or intestinal condition (including Crohn's disease, diverticulitis, or Ogilvie's syndrome);
- A stomach ulcer
- Liver disease.
If you're on Naldemedine while you're pregnant it is possible that your child will experience withdrawal effects from opioids. Tell your doctor whether you are expecting or if you find yourself pregnant.
This medicine can trigger opioid withdrawal symptoms in nursing infants. Don't breastfeed during the time you take naldemedine and for at least three days following the previous dose.
Naldemedine is not a drug that has been approved for use by anyone less than 18 years old.
How to Take Naldemedine?
Follow the directions on the prescription label and review all medication guides and instructions. Follow the medication precisely as directed.It is possible to take naldemedine in conjunction with or even without
Contact your physician if your symptoms do not improve or if they become worse.Naldemedine could not function for those who had taken the opioids for longer than four weeks.The original bottle at room temperature and away from heat and moisture.
When you stop taking opioid pain medication, it is also recommended that you quit using the drug naldemedine.
Details on Dosage
Usual Adult Dose for Constipation (Drug-Induced:
0.2 mg once orally every day
Comments:
Opioid analgesic doses are not likely to require adjustment when beginning this medication.
Treatment should be stopped when opioid pain medications are removed.
Treatment: Treatment for constipation induced by opioids (OIC) for patients suffering from chronic pain that is not cancer-related, as well as patients suffering from chronic pain that is related to prior cancer or treatment that doesn't require frequent (e.g., weekly) dose escalation of opioids.
What Happens If I Miss a Dose?
You should take the medication as quickly as you are able, but do not take your missed dose if you are close to the time of the next dose. Don't take two doses at once.
What Happens If I Overdose?
Get medical attention in an emergency or contact the Poison Help line toll-free at 1-800-222-1222.
What Should be Avoided?
Follow the instructions of your physician regarding any limitations on foods, drinks, or activities.
Interaction with Other Drugs
There are times when it's not recommended to take certain medications simultaneously. Certain drugs may affect the blood levels of other medications that you take, which can create side effects or render the drugs less effective.
Other medications can affect the effects of naldemedine. These include prescription and over-the-counter medicines, vitamins, and herbal products. Discuss with your doctor the medicines you are currently taking as well as any medications you are about to start or stop taking.
