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Name of the Generic: Nalbuphine [NAL-bue-feen]
The Brand Name is Nubain.
Dosage Form: Injectable solution (10 mg/mL; 20 mg/mL)
Drug Class: Opiates (narcotic analgesics)

What is Nalbuphine?

Nalbuphine is a type of opioid painkiller that is used to alleviate moderate or severe pain. It can also be used for the treatment of pain that occurs after surgery or childbirth.Nalbuphine is also used for reasons not mentioned in this guideline.

Side effects of Nalbuphine

Contact a medical professional immediately. Get medical attention immediately if you notice symptoms that indicate an allergic reaction, such as hives, difficulty breathing, or swelling of your lips, face, or tongue.

Opioid medication can impede or stop your breathing, and death could occur. The person who is caring for you must seek urgent medical attention if you experience breath that is slow, with long pauses or blue-coloured lips, or if it is difficult to get back up.

Inform your carer immediately. If you suffer from:

  • Breath that is shallow and is stopped while sleeping;
  • You feel lightheaded, like you're passing out.
  • Extreme tiredness;
  • Extremely constipation;
  • Low levels of cortisol: the feeling of nausea, vomiting, a loss of appetite, nausea, fatigue that is worsening, or weakness;
  • Serotonin levels are high within the body, causing hallucinations, anxiety, sweating, fever, a high heart rate, shivering muscles, stiffness, twitching, loss of coordination, nausea, vomiting, and diarrhoea.

Breathing problems that are serious could be more prevalent in older people as well as those who suffer from debilitation, the syndrome of wasting, and chronic respiratory conditions.

Common negative side effects of nalbuphine include:

  • Drowsiness;
  • Dizziness, spinning sensation;
  • Dry mouth;
  • Headache;
  • Sweating;
  • Cold and clammy skin
  • Nausea, vomiting.

This isn't an exhaustive list of possible side effects, and other effects may also be present. Consult your physician for advice regarding medical adverse effects. You may report any adverse reactions to the FDA at 1-800-FDA-1088.


The risk of fatal side effects could occur when you are given the drug nalbuphine following a recent use of alcohol, other sedatives, tranquilisers, or any other opioid medication.

Before you Take this Drug

You shouldn't be treated with nalbuphine in the event that you are allergic to it or if you suffer from:

  • Extremely severe asthma or breathing issues. severe asthma or breathing problems.
  • An upset stomach or obstruction of the bowel (including paralytic ileus).

Your dosage requirements could be different if you are already taking an opioid medication and are not sensitive to it. Inform your doctor of any other pain medications you've used recently.

Speak to your doctor if you have ever suffered from:

  • Breathing issues, sleep apnea;
  • Issues with your gallbladder, pancreas, or adrenal glands;
  • A head injury, brain tumour, or seizures;
  • The alcohol-related condition or addiction to drugs;
  • Kidney or liver disease,
  • A low heart rate or cardiac attack.

If you're not given nalbuphine in labour, birth, or during labour, inform your doctor that you are pregnant prior to being treated with this medication.

While nalbuphine may be administered in the course of childbirth, receiving this medicine during labour can cause adverse effects for the baby, including slow heartbeats and breathing issues. The baby's breathing, the level of oxygen in his blood, and other vital indicators are closely watched.Talk to a doctor prior to using opioids if you are nursing. Tell your doctor when you experience severe fatigue or a slow breathing rate during breastfeeding.

How to Take Nalbuphine?

Nalbuphine is injected beneath the skin or into a muscle as an infusion into veins. Healthcare professionals can offer the injection. If used to treat pain, nalbuphine should be administered at intervals of 3 to 6 hours, as required. Consult your doctor if the medication appears to have stopped working in relieving discomfort. If you stop taking Nalbuphine abruptly after prolonged use, there is a chance that you will experience uncomfortable withdrawal symptoms. Discuss with your physician how you can effectively stop using the drug nalbuphine.

Details on Dosage

Usual Adult Dose for Pain:

Initial dosage: 10 mg IV, intramuscularly, or subcutaneously every 3 to 6 hours, as necessary.

Maximum single dose: 20 mg
Maximum daily dose: 160 mg
Adult dosages are determined by a 70-kg person. The dosage needs to be adjusted based on the intensity of the physical condition, the pain, and any medications that are taken in conjunction with it.
Monitor patients carefully in the event of breathing depression, particularly in the first 24-72 hours after starting therapy and as their dosage increases.
Because of the dangers of abuse, addiction, and misuse, limit access to patients whose alternatives to treatment have not been accepted, aren't expected to be accepted, have not provided sufficient analgesia, or aren't believed to provide sufficient analgesia.
Use: To manage the effects of pain that is severe enough to warrant an opioid analgesic and for which conventional treatments aren't sufficient.

Usual Adult Dose for Anaesthesia:

Supplement to a balanced anaesthesia:
Dose for induction: 0.3 to 3 mg/kg IV for 10-15 minutes
Maintenance dosage: 0.25 to 0.5 mg/kg in a single IV injection as needed.
This drug must be administered as a complement to general anaesthesia. Those who have been specifically trained in the administration of IV anaesthetics as well as managing the respiratory effects of powerful opioids must have access to naloxone equipment, resuscitative devices, intubation equipment, and oxygen.
It is used as a balanced complement to anaesthesia for postoperative and preoperative analgesia, as well as for obstetrical pain relief during labour and birth.

What Happens If I Miss a Dose?

Since you'll be receiving Nalbuphine in a setting that is clinical it is unlikely to skip the dose.

What Happens If I Overdose?

An overdose of nalbuphine can cause death. Overdose symptoms may include a slow heart rate, extreme fatigue, muscle weakness, clammy and cold skin, bright pupils, and fainting.

Because nalbuphine is administered in a medical setting, you will be monitored carefully to ensure that you don't take excessive amounts of the drug. Your medical staff will be quick to deal with you in case you experience symptoms of an overdose.

What Should be Avoided?

Don't drink or consume alcohol. Dangerous side effects or even death could happen.

Avoid driving and other hazardous activities until you understand what this medication will do to you. Drowsiness or dizziness can lead to accidents, falls, or serious injuries.

Interaction with Other Drugs

Opioid medications can interact with other medications and cause deadly side effects or even death. Be sure your doctor is aware if you take:

  • Cold or allergy medicine or allergy medications, bronchodilator asthma or COPD medication, or diuretic ("water pill");
  • Medications to treat motion sickness and irritable bowel syndrome medicines for motion sickness, irritable bowel syndrome, and bladder overactivity;
  • Other opioids, such as pain medication or prescription cough medicine;
  • a sedative, such as Valium-diazepam, alprazolam, and lorazepam; Xanax; Klonopin; Versed; and many more;
  • Substances that make you sleepy or reduce your breathing rate—a sleep pill or muscle relaxer, a medicine to treat mental illness
  • Serotonin-related drugs can alter the levels in your body. They can be stimulants or medicines to treat depression or Parkinson's disease. migraine headaches, severe infections, vomiting, and nausea.

This list is not comprehensive. Other medications can affect the effects of nalbuphine. These include prescription and over-the-counter medicines, vitamins, and herbal products. The interactions of all drugs are not included in this list.