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What is Miltefosine?
Miltefosine, an anti-parasitic medication used for the treatment of Leishmaniasis, is a parasitic infection caused by.The leishmaniasis that affects the nose, mouth, and throat is treated with miltefosine.This medication guide does not list all possible uses for miltefosine.
Side effects of Miltefosine
If you experience any of the following symptoms of an allergy reaction, seek immediate medical attention: Hives, difficulty breathing, swelling in your lips, face, throat, or tongue.
Miltefosine may cause serious side effects. If you experience:
- Severe or persistent stomach pain (nausea, vomiting, diarrhea);
- Pain in the testicles or scrotum; abnormal ejaculation.
- Easy bruising and bleeding (nosebleeds or bleeding gums);
- Signs of kidney disease: little or no urination; painful or difficult urine production; swelling of the feet and ankles; feeling fatigued or short of breath;
- Liver problems: nausea, stomach pains, fatigue, loss of appetite, and dark-colored urine or stools. Jaundice.
- Severe skin reaction: fever, sore mouth, swelling of the tongue or face, eye pain and burning, then a skin rash (especially on your face and upper body), blistering, and skin peeling.
Miltefosine can have a number of side effects.
- Vomiting, nausea and loss of appetite are all symptoms associated with abdominal pain.
- Diarrhea;
- Headache, dizziness, and drowsiness;
- Itching.
There may be other side effects. For medical advice on side effects, call your doctor.Report side effects to the FDA by calling them at 1-800-FDA-1088.
Warnings
Miltefosine, in animal experiments, has been shown to cause birth defects and even death in unborn children. These effects are not yet known to occur in humans. Do not take miltefosine while pregnant.
Before starting the treatment, you may be required to take a pregnancy test. While you take miltefosine and for 5 months following your treatment end, use effective birth control.
Before you take this drug
Miltefosine should be avoided if:
- A rare skin and nerve condition called Sjogren-Larsson syndrome.
- If you are pregnant.
Tell your doctor about any of the following to ensure that miltefosine will not harm you:.
- Liver or kidney disease
Miltefosine has been shown to cause birth defects and death in utero, as well as affect the fertility of both male and female adult animals. These effects are not yet known to occur in people who use miltefosine. Consult your doctor to determine your personal risk. FDA pregnancy category D. If you're pregnant, do not take miltefosine. You might need to get a pregnancy test negative before beginning this treatment. You should use effective birth control for 5 months following the end of your treatment and while taking miltefosine. Birth-control pills can be less effective if you have diarrhea or vomiting caused by miltefosine. If you experience vomiting or diarrhea after taking miltefosine, ask your doctor if non-hormonal birth control can be used to avoid pregnancy. Your name could be added to a registry if you get pregnant. The purpose of this is to monitor the progress of the pregnancy and evaluate the effects of miltefosine.
Miltefosine is unknown to pass into breastmilk or harm nursing babies. While using miltefosine and for at least 5 months following your treatment, you should refrain from breastfeeding. Miltefosine shouldn't be administered to children younger than 12 years old.
How to take Miltefosine?
Do not take this medicine in larger or smaller amounts or for longer than recommended on the label. Take this medication only as prescribed. Don't exceed the recommended dosage or take it for longer than prescribed. Use with food for stomach upsets. Miltefosine tablets should not be crushed, chewed, broken, or dissolved. It is best to swallow it whole. Inform your doctor of any weight changes. Miltefosine dosages depend on your weight, especially in adolescents and children. Any changes to that can affect the dose. Dehydration can be caused by vomiting or diarrhea. This could lead to renal failure when you take miltefosine. Take this medication with plenty of fluids. You may require frequent blood tests while using miltefosine. You will be required to have your kidney function checked throughout the treatment period and up until 4 weeks following discontinuation. Miltefosine should be taken continuously for 28 consecutive days. This medicine should be taken for the prescribed time. You may experience some improvement in your symptoms before the infection has completely resolved. Keep away from heat and moisture. Store each tablet in the blister until it is ready to use.
Details on dosage
Adult dose for leishmaniasis:
Weight between 30 and 44 kg: Orally take 50 mg twice daily.
Weight of at least 45kg: Orally take 50mg 3 times per day.
Duration: 28 days consecutive
Uses: Treatment of:
Visceral leishmaniasis due to Leishmania donovani
Leishmaniasis cutaneous is caused by L. braziliensis. L. guyanensis. and L. panamensis
mucosal leishmaniasis due to L. braziliensis
The usual pediatric dose for leishmaniasis is:
Twelve years of age or older
Weight 30 to 44 kg: Take 50 mg twice daily.
Weight at least 45kg: Orally take 50mg 3 times per day.
Duration: 28 days consecutive
Uses: Treatment of:
Leishmaniasis visceral due to L. donovani
Leishmaniasis cutaneous due to L. braziliensis (also known as L. guyanensis and L. panamensis)
mucosal leishmaniasis due to L. braziliensis
What happens if I miss the dose?
As soon as possible, take the missed dose. If your next dose is coming soon, forgoing any missed doses would be wise.You should not take more medicine to compensate for a missed dose.
What happens if I overdose?
Contact poison assistance immediately by dialing 1-800-222-1222, or seek immediate medical treatment.
What should be avoided?
If your doctor prescribes any restrictions on foods, drinks, or activities, follow their instructions.
Interaction with other drug
Miltefosine may also interact with other drugs, such as prescription or over-the-counter medications, vitamins, and herbal products. Inform your healthcare providers of all the medicines that you are currently taking and those that you plan to start using.