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What is Midostaurin?
Midostaurin can be used in conjunction with other cancer drugs to treat leukemia. Midostaurin can also be used for certain blood disorders. This includes mast cell leukemia and other cancers that affect the lymphatic, blood, or bone marrow. This medication guide does not list all possible uses of midostaurin.
Side effects of Midostaurin
If you experience any of the following symptoms of an allergy: itching, hives or other rashes, chest pains, difficulty breathing, swelling in your lips, face, or throat, and/or hives,.
Midostaurin may cause serious side effects. If you experience:
- Sore throat, pain in the mouth or surrounding areas, or redness within your mouth
- A sudden feeling of discomfort or pain in the chest; a dry cough; wheezing;
- Signs of Infection Around the Needle: Bruising, Swelling, Warmth, Redness, Oozing, or Bleeding
- Dry mouth and fruity breath smell;
- Low blood counts can cause fever, fatigue, sore mouths or skins, easy bruises, abnormal bleeding, pale hands and feet, as well as feeling lightheaded.
Side effects that may occur from midostaurin include:
- Low blood count and fever
- Bruising, nosebleeds;
- High blood sugar
- Infection around an injection needle
- Mouth sores;
- Cold symptoms like stuffy noses, sneezing, and sore throats;
- Trouble breathing
- Nausea, vomiting, stomach pain, constipation, diarrhea;
- Muscle or bone pain
- Headache, feeling tired;
- Swelling in the hands, ankles, or feet.
There may be other side effects. For medical advice on side effects, call your doctor. Report any side effects by calling the FDA at 1-800-FDA-1088.
Similar/related drugs
omeprazole, lansoprazole, Prilosec, Prevacid, Imatinib, Vincristine, and Gleevec
Warnings
Men and women who use midostaurin must also take birth control.
Before you take this drug
If you have an allergy to midostaurin, then it is best not to use this medication.
If you've ever:
- Lung disease and breathing disorders
Before starting the treatment, you may be required to take a pregnancy test.
Midostaurin may harm the unborn child if either the mother or father are taking this medication.
- Do not take midostaurin while pregnant if you're a woman. While you're taking this medication and for 4 months following your last dose, use birth control. You may find your name on a registry if you're pregnant to monitor the effect of midostaurin.
- Use effective birth control if you're a male. Continue to use birth control at least four months after your last pill.
- If you notice a pregnancy while the mother or father is taking midostaurin,.
Both men and women may be affected by this medicine. Midostaurin is harmful to an unborn child, so it's important to avoid pregnancy. While taking this medication and for at least 4 months following your last dose, you should refrain from breastfeeding. Midostaurin should not be used by those under the age of 18.
How to take Midostaurin?
A test will be performed by your doctor to ensure that midostaurin can treat the condition you have. Read and follow all instructions or guides included with your medication, such as those found on its label. Midostaurin should be taken twice daily (once every twelve hours) along with food. To ensure that you have a constant amount of drug in your system, take your dosages regularly. While taking midostaurin, you may receive medication that prevents nausea and vomiting. Do not take another midostaurin dose if you vomit soon after taking it. Do not take another dose of the medication until you have taken your scheduled next dose. Avoid crushing or opening a capsule of midostaurin. Blood tests may be required frequently (every one to four weeks). Midostaurin should be given up until the body stops responding to it. Follow the instructions of your physician when taking any medication. Each medication comes with instructions. You should not alter your medication or dose schedule without consulting your doctor. Keep midostaurin at room temperature and away from heat, moisture, and humidity.
Details on dosage
Adult dose for acute myeloid leukemia:
On Days 8–21 of each induction cycle and Days 8–21 of each consolidation cycle, take 50mg orally two times a day.
Comments:
This drug is not recommended as an induction treatment for patients with acute myeloid lymphoma (AML).
Information on FDA-approved tests for the detection of the FLT3 mutation in AML is available at.
Combination with standard Cytarabine, Daunorubicin Induction, and Cytarabine Consolidate.
The treatment of newly diagnosed adult AML patients who are FLT3
A FDA-approved test detected mutations.
Adult dose for systemic mastocytosis:
Take 100mg orally, twice daily at intervals of approximately 12 hours.
Comments:
Monitor for toxicities at least once a week during the first four weeks. Then, monitor every two weeks for the following eight weeks. And continue to do so monthly throughout the treatment.
The treatment should continue until the disease progresses or there are unacceptable toxic side effects.
Adult patients suffering from aggressive systemic mastocytosis and systemic lymphocytic leukemia.
Mastocytosis is associated with hematological neoplasm, or mast cell lymphoma (MCL).
Adult dose for leukemia:
Take 100mg orally, twice daily at intervals of approximately 12 hours.
Comments:
Monitor for toxicities at least once a week during the first four weeks. Then, monitor every two weeks for the following eight weeks. And continue to do so monthly throughout the treatment.
The treatment should continue until the disease progresses or there are unacceptable toxic side effects.
Adult patients suffering from aggressive systemic mastocytosis and systemic lymphocytic leukemia.
Mastocytosis is associated with hematological neoplasms (SM-AHN) or mast cell lymphoma (MCL).
What happens if I miss the dose?
If you are almost due for the next dose, skip the missed one. Never take more than one dose at once.
What happens if I overdose?
Reach out for immediate poison assistance by dialing the poison help line: 1-800-222-1222, or seek immediate medical care.
What should be avoided?
If your doctor prescribes any restrictions on foods, drinks, or activities, follow their instructions.
Interaction with other drug
It is sometimes not safe to take certain drugs at the same time. Some medications can cause side effects that increase or decrease the effectiveness of another drug you are taking.Midostaurin can be affected by other drugs, such as vitamins and herbal remedies. Inform your doctor of all the medicines you are taking and those that you stop or start using.