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Generic name: RHO (D) immune globulin [ROE-D-im-MYOON-GLOB-yoo-lin]
Brand names: HyperRHO S/D Full Dose, HyperRHO S/D Mini Dose, MicRhoGAM Ultra-Filtered Plus and Rhophylac are 8 brands of asthma medications available on the market today. To view them all click here!
Drug class: immune globulins

In the U.S., MICRhoGAM has been phased out. There may be equivalents if generic versions have been approved.

What is MicRhoGAM?

MicRhoGAM is a sterile solution made of human blood. Most people (Rh-positive) have Rh in their blood, but others (Rh-negative) do not. Rh-negative people can become exposed to Rh-positive blood by receiving a mismatched transfusion or through pregnancy if the baby is of the opposite blood type. This exposure will cause the Rh-negative blood to produce antibodies, which will attempt to destroy Rh-positive blood cells. It can lead to medical complications such as anemia, renal failure, or shock. MicRhoGAM prevents an immune reaction to Rh-positive blood in people who have an Rh-negative blood type. The medicine can also be used to treat immune thrombocytopenic purpura (ITP). MicRhoGAM can be used in other ways not mentioned in the medication guide.

Side effects of MicRhoGAM

If you experience any of the following symptoms of an allergy reaction, seek immediate medical attention: skin rash, hives, feeling of lightheadedness, chest pain, breathing difficulty, swelling in your lips, face, throat, or tongue.

MicRhoGAM can cause severe side effects. If you experience:

  • Back pain and unusual weakness are symptoms of a fever or chills.
  • Dark urine, pale or yellow skin;
  • Rapid breathing is a sign of confusion and a rapid heartbeat.
  • Signs of kidney failure include swelling, little or no urine, and rapid weight gain.
  • Signs of blood clots include sudden numbness, weakness or slurred words, difficulty with balance or vision, chest pains, blood in the cough, and swelling, redness, or warmth on one or both legs.

Side effects that may occur from MicRhoGAM include:

  • Nausea, diarrhea, vomiting, and stomach pain;
  • Headache, dizziness;
  • Weakness and general malaise;
  • Joint or muscular pain
  • Flushing (warmth or redness);
  • Itching and skin rashes are mild.
  • Increased sweating
  • Pain or tenderness at the injection site.

There may be other side effects. For medical advice on side effects, call your doctor. Report side effects to the FDA by calling them at 1-800-FDA-1088.

Similar/related drugs

Tavalisse, Intron A, Prednisone, Dexamethasone, Triamcinolone, Decadron, and Promacta


If you are suffering from hemolytic anemia, you should avoid taking MicRhoGAM. RHO(D), an immune globulin, can lead to an abnormal breakdown of red blood cells Failure of blood or organ systems may result in life-threatening blood or organ failure. If any of these symptoms appear, consult with a physician immediately. Fever, chills, or back pain. pale skin or red urine. feeling short of breath.

Before you take this drug

This medicine should not be given to you if:

  • Immune globulin A deficiency with antibodies to IgA
  • Hemolytic anemia is a condition in which there are not enough red blood cells.

Tell your doctor about any of the following to ensure that MicRhoGAM will be safe for you:

  • Anemia history;
  • Heart Disease, or an ancestry of Coronary Artery Disease;
  • A bleeding disorder, such as hemophilia;
  • High triglycerides
  • Kidney disease

MicRhoGAM can be used before and after conception. It is known that this medicine will not harm a child during or after pregnancy. Tell your doctor that you plan to get pregnant or are currently pregnant if this medicine is being used to correct a blood transfusion mismatch. You must inform your doctor, if you're an Rh-negative, if you were ever exposed to Rh+ blood during the course of your life. This can include exposure through a transfusion that was not matched or even exposure during your first pregnancy. Notify your doctor of any exposure to Rh-positive blood in your past, such as mismatched transfusions or any exposure during your first pregnancy. MicRhoGAM comes from plasma, which is a part of the blood that may contain infectious agents and viruses. The plasma donated is treated and tested to minimize the possibility of containing any infectious agents. However, there's still a chance that it may transmit disease. Speak to your doctor regarding the benefits and risks of this drug.

How to take MicRhoGAM?

MicRhoGAM can be injected directly into the muscle or vein. This injection will be given in a hospital or clinic setting. After receiving immune globulin, your vital signs, such as breathing, blood oxygen level, and others, will be closely monitored. You may need to have your urine tested at least every 8 hours. MicRhoGAM can be given to treat pregnancy at intervals of about every two weeks during the second half and after birth. The medicine can be given to treat a mismatched transfusion when the symptoms of an allergic reaction appear (when your body begins producing Rh antibodies). You may require frequent blood tests to ensure that this medication is working for you. Your doctor will determine the length of treatment based on your blood tests, even if you don't notice any changes in symptoms. MicRhoGAM may cause false test results for certain lab tests that measure glucose (sugar).Inform any physician treating you of your use.

What happens if I miss the dose?

If you are unable to attend your MicRhoGAM appointment, call your doctor and ask for directions.

What happens if I overdose?

Contact 1-800-222-1222 immediately in case of poisoning and for immediate medical attention.

What happens if I overdose?

After treatment with MicRhoGAM, do not get a live vaccine. The vaccine might not be as effective during this period, and you may not get full protection from the disease. The live vaccines are measles (MMR), rubella, mumps (R), typhoid (chickenpox), varicella (shingles), and the nasal flu vaccine (influenza).

Interaction with other drug

Other medications, such as prescription drugs, over-the-counter products, vitamins, and herbal remedies, may also interact with D-RHO immune globulin. Inform your healthcare providers of all the medicines that you are currently taking and those that you plan to start using.