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Generic Name: Margetuximab Margetuximab [MAR-je TUX-i mab].
Brand Name: Margenza.
Dosage Format: Intravenous solution (25 mg/mL).
Drug Class: HER2 inhibitors.

What is Margetuximab?

Margetuximab can be used in conjunction with cancer medications to treat HER2-positive breast cancer that has spread to other areas within your organs (metastatic). Margetuximab is a treatment for patients who have received at least two chemotherapy treatments for breast cancer. The doctor will perform tests to ensure that your cancer is not caused by an unnatural "HER2/neu" gene (a specific genetic marker). Margetuximab is also used for reasons not mentioned in this guideline.

Adverse effects of Margetuximab

See a doctor immediately. If you are experiencing warning signs of an allergic response, such as symptoms of hives, difficulty breathing, and swelling of your lips, tongue, throat, or face, There are some side effects that can happen when you inject. Inform your doctor that you are feeling sick, dizzy, or nauseated; you feel lightheaded and sweaty. chills, feverishness, or if you experience a headache, rash, joint pain, cough, rapid heartbeats, difficulty breathing, or swelling of your face. Margetuximab could cause severe adverse effects. Consult your physician immediately if you suffer from:

  • New or worsening cough.
  • The appearance of ulcers or blisters in your mouth, swelling or red gums, or trouble swallowing.
  • Heart conditions: racing heartbeats, dizziness, swelling of your lower or face, and rapid weight gain (more than five pounds within a single day). Feeling exhausted.
  • Hand-foot syndrome: blisters, pain bleeding, or an extreme rash on your palms of your hands, toes.
  • Low white blood cell count Low white blood cell counts low white blood cell counts, fever, mouth sores, open sores in the skin, painful throat, cough, and breathing problems.

Common side effects of margetuximab include:

  • Fatigue or feeling weak.
  • Discomfort in the stomach, nausea, vomiting, and a loss of appetite.
  • Diarrhea, constipation.
  • Fever.
  • Hair loss.
  • Headache.
  • Trouble breathing, cough.
  • Numbness, pain, or tingling sensations in your legs or arms.
  • Joint pain or muscle ache.
  • Hand-foot syndrome,
  • Adverse reactions to the injection.

This isn't an exhaustive list of all the side effects. Other side effects could occur. Consult your physician for advice regarding medical adverse effects. You can report any side effects to the FDA at 1-800-FDA-1088.


Margetuximab can cause heart problems. Contact your physician immediately if you experience symptoms like quick or rapid heartbeats, coughing, shortness of breath, swelling, or a rapid increase in weight.

Before you take this drug

Inform your doctor if you have had any heart issues. It is possible that you will need to take an unfavorable pregnancy test prior to commencing this treatment. Margetuximab could cause harm to a baby who is not yet born. Use effective birth control to avoid pregnancy and notify your physician if you are pregnant. Use birth control for a minimum of 4 months following your last dose. It is not recommended to breastfeed during treatment with margetuximab for up to 4 months following the last dose. Consult your physician regarding any risks.

How to take Margetuximab?

Margetuximab is administered in the form of an injection into a vein. Your healthcare professional will give the injection. Margetuximab is usually prescribed every 3 weeks. Follow your doctor's dosage instructions with care. Margetuximab should be administered slowly. The infusion could take between 30 minutes and two hours to finish. The medication is often administered just after receiving other chemotherapy medications. The heart's function could need to be monitored with an electrocardiograph (sometimes known as an EKG) and an ultrasound. Treatment for cancer could be delayed or discontinued permanently in accordance with the results.

Details on dosage

Usual Adult Dose for Breast Cancer:

15 mg/kg IV once every 3 weeks
Comment: Infuse the initial dose over 120 minutes, and then repeat doses of 30 minutes.
This drug can be taken immediately after the end of chemotherapy.
Continue treatment until the progression of the disease is unacceptable.
All therapy proteins, like this drug, are able to trigger an immune reaction.
Use: When combined with chemotherapy, for the treatment of patients aged over 50 with metastatic breast cancer that is HER2-positive and who have had at least two prior anti-HER2 treatments, at least one was prescribed for metastatic cancer.

What happens if I miss the dose?

Consult your physician for the appropriate treatment in the event that you don't make the appointment for your margetuximab shot.

What happens if I overdose?

Because margetuximab is administered by a health specialist in a medical setting, it is highly unlikely for an overdose to occur.

What should be avoided?

Follow the doctor's advice regarding restrictions on drinks, food, or activities.

Interaction with other drugs

Margetuximab may have lasting impacts on the body. At least four months after the final dose of margetuximab, you shouldn't be treated with any other cancer treatments. Inform your doctor about your treatment with margetuximab. Other drugs can interact with margetuximab, such as prescription and over-the-counter medicines, vitamins, and herbal products. Inform your doctor about your current medications and any medications you begin or stop taking.