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Janumet XR

Generic name: metformin and sitagliptin [met-FOR-min-and-SI-ta-glip-tin]Brand names: Janumet, Janumet XR
Class of drugs: Combinations of anti-diabetic medications

What is Janumet XR?

Diabetes medications that control blood sugar levels Metformin reduces glucose production in the liver and decreases glucose absorption by the intestines. Sitagliptin regulates the levels of insulin that your body produces following a meal.

Janumet XR is a combination medication that can be used with diet and physical activity to control blood sugar in adults with type 1 diabetes. Janumet XR does not treat type 1 diabetes. Janumet XR can be used in other ways not mentioned in this guide.

Side effects of Janumet XR

If you experience symptoms of an allergic reaction, such as hives, difficulty breathing, swelling on your face or in your throat, or a severe reaction to your skin (fever or sore throat, pain in the eyes, or skin irritation), or if your skin has rashes that are red or purple and cause blistering or peeling, seek emergency medical attention.

If you experience any of the following symptoms: severe abdominal pain that spreads to your back; nausea or vomiting; loss of appetite or rapid heartbeats,

Metformin can cause lactic acidosis. This condition is fatal. Seek emergency medical attention if you experience even mild symptoms, such as:

  • Unusual muscle pain;
  • Feeling cold
  • Trouble breathin
  • Feeling dizzy, lightheaded, tired, or very wea
  • Stomach pain, vomiting, or
  • Heart rate irregularity

If you experience any of the following serious side effects, call your doctor immediately.

  • Severe autoimmune reactions—blasps, itching;
  • You may experience severe pain or persistent joint pain.
  • Little or no urinating is acceptable.
  • Symptoms of heart failure include shortness of breath (even when lying down) and swelling in the legs or feet. Rapid weight gain.

Some of the side effects that janumet xr can cause include:

  • Low sugar
  • Upset stomach, indigestion, gas, diarrhoea, nausea, vomiting;
  • Headache weakness
  • Cold symptoms like a runny or stuffy nose, sneezing, and sore throat

There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.


Janumet XR should not be used if you suffer from severe kidney disease or diabetic ketoneacidosis. (Call your doctor to get treatment.)

You could develop lactic acidosis. This is a dangerous buildup of lactic acid in your blood. If you experience unusual muscle pains, difficulty breathing, stomach pains, dizziness, or feel cold or very tired, call your doctor.

Before you take this drug

This medicine should not be used if you're allergic to sitagliptin or metformin (Januvia) or have severe kidney problems or diabetic ketoacidosis. Call your doctor for insulin treatment.Tell your doctor about any of the following:

  • Kidney disease (your kidney function will need to be tested before and during the time you take this medication);
  • Liver disease
  • Heart disease
  • Pancreatitis;
  • High triglycerides
  • Gallstones
  • Alcoholism.

You can develop lactic acidosis. This is a dangerous buildup of lactic acid in your blood. You may be at greater risk if you suffer from other medical conditions, have a serious infection, or are older than 65. Consult your doctor to determine your risk. You may need to temporarily stop using Janumet XR if you are scheduled for surgery or any type of x-ray or CT scan that uses a dye injected directly into your veins. Tell your carers that you're taking this medication.

If you're pregnant or plan to become pregnant, follow your doctor's advice about this medicine. Metformin can stimulate ovulation and increase the risk of unintentional pregnancy in premenopausal women. Speak to your doctor regarding your risks.

Breastfeeding may not be possible while taking this medication. You should consult your doctor if you are concerned about any risks. The use of this medicine by those under 18 is not recommended.

How to take Janumet XR?

Read all the instructions or guides that come with your medication and follow the directions. Sometimes, your doctor will change the dose. You must take the medication exactly as prescribed.

Janumet XR can be taken with food. Do not chew, crush, or break the tablet. Some tablets have a shell that is not absorbed by the body or melted. Some of the shell may be found in your stool. This is not a problem, and the medication will still be effective.

If you notice a tablet in your stools several times, call your doctor. If you have low blood glucose (hypoglycemia), then you may feel very hungry or dizzy. You might also be confused, anxious, or shaky. If you want to treat hyperglycemia quickly, consume or drink sugary foods or drinks (such as fruit juice, hard candies, crackers, or raisins).

In the event of severe hypoglycemia, your doctor may prescribe a glucagon injectable kit. Make sure that your family and friends are familiar with how to administer this injection in case of an emergency. Watch for signs of hyperglycemia (hyperglycemia), such as increased thirst and urination.

Stress, illness, surgery, and alcohol consumption can affect blood sugar levels. Consult your doctor before making any changes to your medication or dose schedule. Janumet XR may be part of a comprehensive treatment programme that includes diet, exercise, and weight management, as well as blood sugar testing and other medical care. You should follow your doctor's advice.

You will need to have your blood tested frequently. Store away from heat and moisture at room temperature.

What happens if I miss the dose?

If you are close to your next dose, skip the missed dose. Never take two doses of the same medicine at once.

What happens if I overdose?

You should seek emergency medical care or call Poison Help at 1-800-222-1222. You may be suffering from a severe low blood sugar level (extreme weakness or nausea, sweating tremors and confusion, difficulty speaking, rapid heartbeats, or seizures).

What should be avoided?

Avoid alcohol. Alcohol lowers your blood sugar levels and can increase the risk of lactic acidosis.

Interaction with other drug

Janumet XR can be affected by many drugs, causing it to become less effective or increasing your risk of lactic acidosis. These include prescription and non-prescription medicines, vitamins, and herbal products. This list does not include all possible interactions. Inform your doctor of all the medications you are taking, as well as any new ones