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Itraconazole

Itraconazole (IT-rah-KON-ah-zole)
Brand names: Sporanox, Tolsura, Onmel, and Sporanox pulsepak
Dosage forms: oral capsule (100 mg; 65 mg); oral solution (10 mg/ml).
Drug class: Azole antifungals

What is Itraconazole?

Itraconazole, an antifungal drug, is prescribed to adults for the treatment of infections caused by fungus. This includes infections of any part, including the lungs or mouth, fingernails, or toenails.

Tolsura is not intended for the treatment of fungal infections in the toenails or fingernails. Use only the brand of medication and strength prescribed by your doctor to avoid medication mistakes. Itraconazole can be used in other ways not mentioned in this guide.

Side effects of Itraconazole

If you experience any of the following symptoms, seek immediate medical attention: hives; severe skin reactions; tingling or numbness in your arms and legs; difficulty breathing; swelling on your face, lips, or tongue; or difficulty breathing

Itraconazole should be stopped immediately if you experience any of the following symptoms: fatigue or shortness of breath; a cough with mucus; rapid heartbeats; or swelling.

Continue taking itraconazole, but contact your doctor immediately if:

  • A feeling of confusion or light-headedness (like you could pass out);
  • Double vision, blurred vision, ringing ears, hearing problems
  • Fast heartbeats;
  • Loss of bladder control, numbness, and tingling;
  • There is little or no urinating; there may be pain or burning in the urinal area.
  • Constipation; low sodium level; leg cramps. Irregular heartbeats.
  • Pancreatitis: severe pain spreading from your upper stomach to your back; nausea; and vomiting.
  • Liver problems: nausea, upper stomach discomfort, fatigue, loss of appetite Dark urine and clay-coloured stools. Jaundice.

Itraconazole side effects may include:

  • Headache, dizziness, drowsiness, tiredness;
  • Increased blood pressure
  • Rash, itching;
  • Nausea, vomiting, stomach pain, diarrhea, constipation;
  • Swelling;
  • Atypical liver function or blood test results;
  • Joint or muscle pain
  • Unusual or unpleasant taste in the mouth
  • Hair loss;
  • Impotence, erection problems,
  • Changes in your menstrual cycle

There may be other side effects.For medical advice about side effects, call your physician. You can also reach the FDA at 1-800-FDA-1088 in order to report them.

Warnings

Itraconazole should not be taken if you've ever suffered from heart failure. If liver or kidney disease is present, itraconazole should not be taken with colchicine or fesoterodine. Itraconazole can harm an unborn child. Do not get pregnant for at least 2 months after taking your last dose of itraconazole.

Itraconazole should be stopped immediately if you experience any of the following symptoms: feeling tired or short of breath, mucusy cough; rapid heartbeats or swelling; rapid weight gain; or sleep issues.

Itraconazole can cause life-threatening side effects when taken with other medications. Inform your doctor of all the medications you are taking and those that you have started or stopped using.

Before you take this drug

This medicine should not be taken if you're allergic to itraconazole or other similar medications such as fluconazole and ketoconazole. You also shouldn't take it if congestive cardiac failure has ever occurred.

Itraconazole can cause life-threatening side effects when taken with other medications. If you have taken other medications in the last 2 weeks, your doctor may alter your treatment plan.

  • Avanafil;
  • Cisapride;
  • Eliglustat;
  • Irinotecan;
  • Isavuconazonium;
  • Methadone;
  • Naloxegol;
  • Ranolazine;
  • Ticagrelor;
  • Lurasidone or pimozide (antipsychotic medications);
  • Lomitapide, lovastatin, and simvastatin (cholesterol-lowering medicines);
  • Dihydroergotamine, ergonovine, ergotamine, or methylergonovine (ergot medicines);
  • Eplerenone, felodipine, ivabradine, or nisoldipine.
  • Disopyramide, dofetilide, dronedarone, or quinidine are all medicines for heart rhythm disorders.
  • Oral midazolam or triazolam (valium-like sedatives).

If liver or kidney disease is present, itraconazole should not be taken with colchicine or telithromycin.

Itraconazole can harm an unborn child. Prevent pregnancy by using effective contraception while taking this medication and for 2 months following your last dose. Inform your doctor immediately if you fall pregnant.

Tell your doctor about any of the following:

  • Heart problems
  • Lung disease, such as cystic fibrosis
  • Liver or kidney disease
  • A weak immune system.

Breastfeeding may not be possible while taking this medication. You should consult your doctor if you are concerned about any risks.

How to take Itraconazole?

Read all instructions or guides that come with your medication and follow all directions. Follow the directions on the label. Itraconazole should not be shared with anyone else, even if the other person has similar symptoms. Itraconazole capsules can be taken with or without food.

Do not open, crush, chew, or break the capsule. Itraconazole, an orally administered solution (liquid), should be taken on an empty stomach at least one hour before or two hours after eating. Swish the liquid around in your mouth before swallowing.

Measuring liquid medicine is important. Use the provided dosing device or a dose-measuring tool (not a spoon). The pulsepak comes with a special schedule of dosing that involves not taking the medicine for several days in a row. Please follow all instructions for dosage.

If your doctor prescribed itraconazole liquid, you should not use capsules. To avoid medication mistakes, only use the strength and form prescribed by your doctor. Itraconazole can be taken with non-diet coke if you are also taking a stomach acid-reducing medication (Tagamet, Pepcid, Axid, Zantac, etc.).

Even if you feel better quickly, continue to take this medication for the entire prescribed time. You can get infections resistant to medications if you skip doses. Itraconazole does not treat a virus such as the flu or the common cold. You may require frequent medical tests. Store away from moisture, heat, and light at room temperature.

What happens if I miss the dose?

If you are almost due for your next dose, skip the missed one. Never take two doses of the same medicine at once.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

What should be avoided?

Itraconazole can affect your reaction. Avoid driving and other hazardous activities until you are sure of how itraconazole affects you. You may be unable to react properly.

Avoid taking antacids 1 hour before or 2 hours after taking itraconazole. Some antacids may make it more difficult for your body to absorb itraconazole.

Interaction with other drug

It is sometimes not safe to take certain medications together. Some drugs may affect the blood levels of drugs that you are taking, causing side effects or making them less effective.

Itraconazole can interact with many drugs, and certain drugs shouldn't be taken together. Inform your doctor of all the medicines you are taking and those that you have stopped using. Included are prescription and over-the-counter medicines, vitamins, and herbal products. This list does not include all possible interactions.