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Generic name: desirudin [DES-i-ROO-din]

Drug class: Thrombin inhibitors

What is Iprivask?

Iprivask (a thrombin inhibitor) is an anticoagulant that prevents blood clots from forming.

Iprivask prevents a blood clot known as deep venous thrombosis, which can lead to blood clots in the lungs (lung embolism). Dvts can develop after certain types of surgeries. This medicine should be used after hip surgery. Iprivask can be used in other ways not mentioned in this guide.

Side effects of Iprivask

If you experience any of the following symptoms of an allergic reaction, seek immediate medical attention: hives, difficulty breathing, swelling of your lips, face, tongue, or throat.

Seek emergency medical care if you experience any of the following symptoms: lower back pain; numbness, muscle weakness, or loss in bladder or bowel function.

Iprivask may cause serious side effects. If you experience:

  • Easy bruising and bleeding (nosebleeds or bleeding gums; heavy menstrual bleeding);
  • Pain, swelling, or drainage where an injection was made or a wound is present;
  • Any bleeding that does not stop, whether it is from a wound or an injection,
  • Feeling dizzy, weak, or like you could pass out is a common symptom of a headache.
  • Urine that appears red, pink, or brown
  • Bloody or tarry stool, vomiting blood, or vomit that looks like coffee grounds

Adults aged 75 or older may experience more serious side effects.

Iprivask side effects may include:

  • Nausea;
  • Vomiting;
  • Fever.

There may be other side effects.For medical advice regarding side effects, reach out to your physician. The FDA can be contacted at 1-800-FDA-1088 to report side effects.


Iprivask should not be used if there is active bleeding or uncontrolled blood clotting.

Iprivask may cause a serious blood clot in your spinal column if it is used during a spinal tap or when you receive epidural or spinal anesthesia. This can happen if other medications are being taken that affect blood clotting (such as blood thinners, nsaids, Ibuprofen, Advil, or Aleve).If you experience symptoms such as lower back pain, numbness, muscle weakness, or loss in bladder or bowel function, seek emergency medical attention.

Before you take this drug

This medicine should not be used if:

  • Active or uncontrolled bleeding
  • An irreversible blood clotting disorder.

Iprivask may cause a serious blood clot to form around your spinal cord if you have a spinal tap performed or are given spinal anesthesia. This type of blood clot can cause permanent or long-term paralysis. More likely to occur if:

  • You have an injury to the spinal cord.
  • You have a spinal cath in place.
  • You have had spinal surgery before, or you've had repeated spinal taps.
  • You are taking an NSAID, such as ibuprofen, naproxen, diclofenac (Aleve), indomethacin (meloxicam), or any other NSAID.
  • You are taking a blood thinner to treat or prevent blood clots (Warfarin or Coumadin).

Tell your doctor about any of the following:

  • Kidney disease
  • Liver disease.

Iprivask can cause you to bleed easily, particularly if:

  • A bleeding disorder caused by a disease or inherited
  • A hemorrhagic stroke
  • Uncontrolled high blood pressure
  • You may be bleeding from the head.
  • Diabetes can cause eye problems.
  • If you have had bleeding in the lungs, stomach, or intestines within the last 3 months,
  • Recent surgery, a transplant, or a biopsy of an organ
  • If you are taking steroid medication (prednisone, dexamethasone, and others) or a salicylate (aspirin, diflunisal magnesium salicylate, salsalate, and others),

Inform your doctor that you are expecting. Iprivask should not be used while breastfeeding.

How to take Iprivask?

Read all instructions or guides that come with your medication and follow all instructions on the label. Follow the directions on the label. Iprivask can be injected into the skin. You may be taught how to use the medicine by a healthcare provider. Iprivask can be given up to 12 days following your surgery, usually every 12 hours. Dosage instructions should be followed very closely.

Please read and follow all instructions for use that come with your medication. If you do not understand the instructions, ask your doctor or pharmacist. Iprivask should be diluted with a liquid before use. If you are using injections on your own, make sure that you know how to mix and store them. Only use the syringes and needles that come with Iprivask. Only prepare an injection when you're ready to administer it. If the color of your medicine has changed or if it contains particles, do not use it. For new medication, call your pharmacist.

You may require frequent medical tests. Store the powders and diluents at room temperature, away from heat, moisture, and light. Store Iprivask at room temperature, away from lights, for 24 hours after mixing. Only use a needle or syringe once, and then store them in a "sharps container" that is puncture-proof. Be sure to follow local or state laws on how to properly dispose of the container. Keep the container out of reach of pets and children.

What happens if I miss the dose?

If you forget to take your Iprivask, call your doctor.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention. An overdose may cause excessive bleeding.

What should be avoided?

Avoid rubbing your skin after injecting Iprivask to prevent bruising.

Avoid any activity that could increase your risk of bleeding or injury. Take extra precautions to avoid bleeding when shaving or brushing your teeth.

Interaction with other drug

Tell your doctor if you are taking any other medications, including:

  • Abciximab, clopidogrel, dipyridamole, eptifibatide, ticlopidine, and tirofiban
  • Alteplase, reteplase, tenecteplase, urokinase;
  • Argatroban, bivalirudin, dabigatran, fondaparinux, lepirudin, rivaroxaban;
  • Dalteparin, enoxaparin, heparin, and tinzaparin.

This list is incomplete. Iprivask may be affected by other drugs, such as prescription and over-the-counter medicines and vitamin and herb products. This list does not include all drug interactions.