Hyqvia

What is Hyqvia?

Hyaluronidase helps your body absorb injected medications.It is a sterile solution made of human plasma. It contains antibodies that help protect your body against infections caused by various diseases.When combined with Hyqvia, they treat adults with primary immune deficiency.This medication guide does not list all possible uses of Hyqvia.

Side effects of Hyqvia

If you experience any of the following symptoms of an allergic reaction, seek emergency medical attention: hives, wheezing or difficulty breathing, dizziness, feeling as if you may pass out, or swelling of your lips, face, tongue, or throat.

Hyqvia can cause serious side effects. If you experience:

• Signs of a brain blood clot: sudden numbness, weakness or slurred words (especially on one side), problems with vision and balance
• Signs of a blood clot in your heart or lung: chest pain, rapid heartbeat, sudden hack, wheezing, and rapid breathing;
• Signs of a blood clot in the arm or leg include pain, swelling, warmth, and redness or discoloration.
• Signs of kidney problems: swelling, rapid weight gain, and no or little urination;
• Signs of a blood-cell disorder: pale or yellowed complexion, dark urine, feeling dizzy or lightheaded, rapid heartbeat, weakness, etc.
• Liver problems: rapid heart rate; dark urine; jaundice.
• Blue lips, pale or blue-colored fingers or toes, chest pain, difficulty breathing, or
• Signs of a new infection include: high fever; flu symptoms; sores in the mouth; severe headache; neck stiffness; and increased sensitivity to lights. Other signs are nausea and vomiting.

Hyqvia side effects may include:

• The injection site may be swollen, red, itchy, or painful.
• Nausea, vomiting;
• Fever;
• Tired feeling

There may be other side effects. For medical advice on side effects, call your doctor. Contacting the FDA in regards to side effects can be done at 1-800-FDA-1088.

Warnings

Hyqvia should not be used if you've ever had an allergic reaction severe to immune globulins or have IgA deficiency and antibodies to IgA.Immune globulins can cause blood clots. This is especially true if there are certain risk factors, such as cardiovascular disease or circulation problems. Contact your doctor immediately if you experience sudden numbness, weakness, difficulty speaking or seeing, chest pain, shortness of breath, or pain and swelling in your arm or legs.

Before you take this drug

If you've ever had an allergy reaction to Hyqvia or if:

• Immune globulin A deficiency (iga), with antibodies to iga

Immune globulin may cause kidney damage or blood clots if you are at risk. Tell your doctor about any of the following to ensure that this medicine is right for you:

• Heart disease is a problem with blood flow or blood vessels.
• A history of stroke or blood clots;
• Diabetes;
• Kidney disease
• If you are using estrogens (birth control pills) or hormone replacement therapy,
• If you are dehydrated,
• If you are 65 or older,
• If you are bedridden because of a severe illness,
• If you use a catheter,

FDA pregnancy class C There is no information on whether Hyqvia can harm an unborn child. You should tell your doctor if you plan to become pregnant while taking this medication.This medication has not been reported as passing into breast milk.It's also unknown if this medication could harm a baby who was nursing. You should tell your doctor if you're breastfeeding a child.The immune globulins are made from plasma, which is a part of the blood that may contain viruses or other infectious agents. Plasma donated is treated and tested to reduce the possibility that it contains infectious agents. However, there is a very small chance it could still transmit disease. Speak to your doctor about any risks or benefits associated with using this medication.

How to take Hyqvia?

Hyqvia should be taken every four weeks. Please follow all the instructions on the prescription label. Your doctor may change the dose from time to time in order to get you the best results. Hyqvia should not be taken in higher or lower doses or for longer periods than prescribed.Hyqvia can be injected using an infusion device. The medicine is injected into the body via a catheter that's placed either under your skin or in a vein. You will be shown how to inject medicine using an infusion pump by a healthcare provider. If you don't understand the instructions, do not inject yourself. For help, call your doctor, pharmacist, or nurse.Keep a journal if you are using this medicine at home. Record the dates, times, and location of the injection.Hyqvia is available in a kit containing a "dual-vial" unit. The small vial is hyaluronidase, and the larger vial is immune globulin. These two medications should not be mixed. Inject hyaluronidase, then immune globulin in 10 minutes. Infusions should not contain any other medications.

Hyqvia kits come with instructions on how to prepare and inject your dose. Please follow the instructions carefully. If you have questions, ask your doctor or pharmacist.Shaking the vials can ruin the medication. Do not prepare your dose until you are ready for an injection. The medicine should be clear with no color. However, the immune globulin can appear pale yellow. If either medicine appears cloudy or contains particles, do not use it. For new medicines, call your pharmacist.Each vial or bottle of hyaluronidase (or immune globulin) is only for one single use. After one use, throw away the vial, even if some medicine is left.Only use disposable items (syringes, needles, catheters, and tubing) once. Use syringes and needles in accordance with any local or state laws. Ask your pharmacist how to dispose of sharps in a container that is puncture-proof. This container should be kept out of the reach of pets and children.

You may need to have frequent blood tests while using Hyqvia.Hyqvia can produce unusual results in certain medical tests. Hyqvia should be mentioned to any doctors who treat you.Keep the original carton of the dual vial in the fridge. Protect from light and do not freeze.Allow the medicine to come to room temperature by taking a vial from the refrigerator 60 minutes prior to preparing a dose. Once the vial reaches room temperature, it should not be returned to the fridge.Store the medicine at room temperature for up to three months.Keep it away from moisture, heat and light sources. Hyqvia that has not been used by the expiration dates is to be thrown away.The medicine should not be heated before use.

What happens if I miss the dose?

If you forget to take a dose, call your doctor.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

What should be avoided?

Do not inject Hyqvia into any area of skin that is swollen or red. This could spread the infection to other areas of your body.Hyqvia should not be used in conjunction with a live vaccine. During this period, the vaccine may not be as effective, and you may not receive full protection from disease. Live vaccines are available for measles (mumps), rubella (MMR), yellow fever, typhoid (rotavirus), varicella, chickenpox, zoster, and influenza (nasal flu).

Interaction with other drug

Your kidneys can be damaged by immune globulin. This effect can be increased if you use other medications, such as antivirals (antiviral drugs), chemotherapy, injected bacteria, medicine for bowel problems, medicine to prevent rejection of organ transplants, injectable osteoporosis medicine, or some pain relievers and arthritis medicines.Other drugs, such as vitamins and herbal remedies, may also interact with hyaluronidase or immune globulin. Inform your healthcare providers of all the medicines you are taking and those you plan to take. This medication guide does not list all possible interactions.