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Drug class: colony-stimulating factors.
Generic name: Tbo-filgrastim.

What is Granix?

Granix is an artificial form of a natural protein that helps stimulate the production of white blood cells. White blood cells are important in fighting infections.Granix can be used to reduce the length of severe neuopenia caused by chemotherapy and certain cancer drugs.Granix can be used by adults and children over 1 month of age.Granix can be used in other ways not mentioned in this guide.

Side effects of Granix

If you experience any of the following: hives, wheezing or difficulty breathing, rapid heart rate, feeling lightheaded, experiencing excessive sweating, swelling on your face, lips, and tongue, or swelling in your throat, face, mouth, and/or lips,Capillary Leak Syndrome is an uncommon but potentially life-threatening side effect of Tbofilgrastim treatment. If you experience symptoms such as a stuffy or running nose, followed by fatigue or weakness, or sudden swelling of your arms, legs, or other body parts, call your doctor immediately.

Granix can cause serious side effects. If you experience:

  • Back pain and stomach pain
  • A general feeling of ill will
  • Signs of kidney problems include blood in the urine, swelling on the face or ankles, and little or no urination.
  • Signs of infection: fever or redness;
  • Signs of acute respiratory distress syndrome: fever with shortness of breath
  • Signs of a ruptured stomach: pain in the upper abdomen that spreads to your shoulder on the left.

Granix can cause the following side effects:

  • Bone pain is a painful condition.

There may be other side effects. Call your doctor immediately if experiencing side effects; alternatively, for more information regarding adverse reactions call the FDA directly on 1-800-FDA-1088 and report.


Please read and heed all instructions listed on your medication label or package before taking. It is also essential that you inform your healthcare provider of all medical conditions, allergies and medicines you take as this information could impact their care plan.

Before you take this drug

Granix should not be used if you have an allergy to Filgrastim, Neupogen, or Pegfilgrastim.

Tell your doctor about any of the following:

  • A haemoglobin disorder, such as sickle cell anaemia or thalassemia.
  • Kidney disease
  • If you have a scheduled radiation treatment, bone scan, or other medical test,

Granix, a G CSF, can rupture your spleen and cause death. Those concerned should consult their physician.This medicine is not known to harm an unborn child. Inform your physician immediately if you are pregnant, planning on becoming pregnant, or contemplating becoming pregnant.Breast-feeding may not be possible while taking this medication. You should consult your doctor if you are concerned about any risks.

How to take Granix?

Read all instructions or guides that come with your medication and follow all directions. Follow the directions on the label.Granix is injected into the skin. You may be taught how to use the medication properly by a healthcare provider.Please read and follow all instructions that accompany your medication carefully. If you do not understand the instructions, ask your doctor or pharmacistDo not prepare an injection until you are absolutely sure. The prefilled syringe should not be shaken. If the medicine contains particles, do not use it. For new medication, call your pharmacist.The first dose is normally given 24 hours after the chemotherapy. You will be receiving daily injections until your blood counts return to normal.Granix should not be administered within 24 hours of your next chemotherapy treatment.Granix should not be stopped or changed without consulting your doctor.If you accidentally get this medication on your skin, clean it with warm, soapy water.Each prefilled syringe can only be used once. After one use, throw it out, even if the medicine is still inside.Your doctor will want to know how long you should be treated with Granix.Do not freeze. Store it in the fridge. Keep away from the light.Let the medicine reach room temperature before you inject it. Do not leave medicine out longer than five days.Only use a needle or syringe once, and then store them in a "sharps container" that is puncture-proof. Be sure to follow local or state laws on how to properly dispose of the container. Keep the container out of reach of pets and children.Tbo-filgrastim can cause bone pain. You may be prescribed acetaminophen, ibuprofen, or other pain relievers by your doctor. Only take the recommended dosage.

What happens if I miss the dose?

If you miss a Granix appointment or a dose of Granix, call your doctor to get instructions.

What happens if I overdose?

Call 1-800-222-1222 if you believe you may have taken poison and require assistance immediately or seek medical assistance immediately.

What should be avoided?

Granix should not be injected into skin that has been bruised, swollen, irritated, or is hard.Avoid getting the medicine in your eye. If you do get it in your eyes, rinse immediately with water.

Interaction with other drug

Granix may be affected by other drugs, such as prescription and over-the-counter medicines, vitamins, and herbal products. Inform your doctor of all the medicines you are taking and those that you stop or start using.