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Gadobenate Dimeglumine

Generic name: gadobenate dimeglumine [GAD-oh-BEN-ate-dye-MEG-loo-meen]

Brand name: Multihance
Dosage format: intravenous solution (529 mg/mL)
Classification of drugs: magnetic resonance imaging contrast media

What is Gadobenate Dimeglumine?

Gadobenate dimeglumine is a contrast drug with magnetic properties. It is employed in conjunction with magnetic resonance imaging (MRI) or magnetic resonance imaging (MRA) to permit organs, blood vessels, and other non-bony tissues to be more clearly seen when using MRI as well as MRA.Gadobenate dimeglumine can assist in the diagnosis of certain diseases of the brain and the spine (central nervous system). It is also used to detect atherosclerosis (clogged blood vessels).Gadobenate dimeglumine can also be used to treat conditions that are not mentioned in this guide.

Side effects of Gadobenate dimeglumine

Contact a medical professional immediately. Get medical attention immediately if you notice symptoms or warning signs of an allergic response, such as symptoms of hives, difficulty breathing, or swelling of your lips, face, or tongue.Certain side effects of gadobenate dimeglumine could occur in the days following the injection.Gadobenate dimeglumine could cause life-threatening conditions for people suffering from kidney disease. Consult your doctor immediately if you exhibit any signs of this disease, for example:

  • Burning, itching, swelling, scaling, tightening, or the skin's hardening
  • Muscles weak;
  • Joints stiffness and pain in the hands, arms, legs, feet, or arms;
  • Deep bone pain in your ribs or hips could be indicative of deeper issues with either, both need to be addressed.
  • Problems getting it moving.
  • Skin coloration or redness.

Contact your doctor at the earliest opportunity if you are suffering from:

  • Kidney issues: no or little urination; hard or painful urine; swelling in your ankles and feet; feeling tired or dehydrated;
  • A seizure (convulsions);
  • Beats of your heart or the sound of fluttering your chest
  • Breathing issues
  • Discomfort, burning, inflammation, blistering, or skin changes after the injection was administered.

Common negative side effects of gadobenate-dimeglumine can be:

  • Headache;
  • Nausea;
  • A strange or unpleasant flavor inside your mouth

This isn't an exhaustive list of all the side effects. Others could happen. Contact your physician to seek medical advice on adverse effects. Report any side effects directly to the FDA at 1-800-FDA-1088.

Similar or related drugs

Magnevist, Gadavist, Dotarem, gadobutrol, gadoterate meglumine, gadoteridol, and Multihance


Gadobenate dimeglumine could cause a serious condition for those suffering from severe kidney diseases. It is not recommended to take this medicine if you suffer from kidney disease or are undergoing dialysis.

Prior to using this drug

Gadobenate dimeglumine could cause a serious condition for those suffering from severe kidney diseases. You shouldn't take this medicine if you suffer from kidney disease or are taking dialysis.Gadobenate dimeglumine may remain within your body for a few months or even years following the administration of gadobenate dimeglumine. It's unclear if it can cause health problems for people who have functioning kidneys. Discuss with your doctor if you have had multiple scans with contrast agents, and also provide the date of the last scan.Gadobenate is not recommended for gadobenate dimeglumine in case you are allergic to it.

Speak with your physician if you have ever suffered from:

  • Kidney disease;
  • Reaction to contrast agent
  • Diabetes;
  • Hypertension;
  • Liver disease;
  • Asthma, asthma, fever, and food or drug allergies
  • An injury, surgery, or severe infection;
  • If you are older than sixty years of age,

It isn't clear if this medication will affect a newborn baby. Inform your doctor if you are expecting.It might not be safe to breastfeed while taking this medication. Talk to your doctor regarding any risks.

How do I take Gadobenate Diglumine?

Gadobenate dimeglumine will be administered as an injection into the vein. The healthcare professional will give the injection.Inform your doctor that you are experiencing any pain, burning, or swelling in the area of your IV needle during the time the medication is administered.Your physician or healthcare professional might want to observe your condition for a short period following the conclusion of your test. This is to ensure that you don't suffer from any adverse reactions or side effects.

Info on dosage

Usual Adult Dose of CNS Magnetic Resonance Imaging:

0.1 millimolar/kg (0.2 mg/kg) in a bolus that is a rapid intravenous injection. To ensure that the medium is fully injected, this medium must be followed by a saline flush of at least 5 mL.

Usual Adult Dose for Magnetic Resonance Angiography:

MRA of the renal and aorto-iliac-femoral vessels:
0.1 millimolar/kg (0.2 mg/kg) in a bolus that is rapid intravenous injection, followed by the flushing of saline that is at least 20 mL, either manually or by using an automated injector system.
Imaging can be initiated right after gadobenate meglumine injection, with scan delay determined using a test bolus or an automatic bolus detection. If bolus timing cannot be established by an automated pulse sequence for contrast detection, then an injection test of about 1-2 ml of gadobenate meglumine is recommended to determine the delay of the scan.

Usual Pediatric Dose for CNS Magnetic Resonance Imaging:

2 years or older:
0.1 millimolar/kg (0.2 milliliters/kg) for a quick intravenous bolus injection. To ensure that the medium is fully injected, this medium must be followed by a flush of saline that is at least 5 mL.

What happens if I miss the dose?

Because gadobenate dimeglumine can only be used in conjunction with your MRI and not during your MRI, you won't be following a schedule of dosing.

What happens if I overdose?

Because the medication is prescribed by a medical expert in a medical environment, it is highly unlikely for an overdose to occur.

Avoid this

Follow the instructions of your physician regarding restrictions on drinks, food, or activities.

Interaction with other drug

Discuss with your doctor all the drugs you've taken recently, including cancer drugs, like:

  • Cisplatin;
  • Daunorubicin, doxorubicin;
  • Etoposide;
  • Methotrexate;
  • Paclitaxel;
  • Tamoxifen;
  • Vinblastine, vincristine.

This list is not comprehensive. Other medications can be incompatible with gadobenate dimeglumine, such as prescription and over-the-counter medications, vitamins, and herbal products. The interactions of all potential drugs are mentioned in this medication guide.