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Generic name: estradiol vaginal (systemic) [ES-tra-DYE-ole-VA-jin-ul]
Drug class: estrogens

What is Femring (systemic)?

Estradiol is a kind of estrogen, which is a female sex hormone that regulates various bodily processes.

Some estradiol-based products that are placed directly into the vagina are utilized to treat "local" vaginal menopausal manifestations (such as burning, dryness, or irritation). Other vaginal estradiol products can be used to treat vaginal menopausal symptoms and signs that affect other areas of the body (such as hot flashes). The vaginal estradiol type is known as having "systemic" effects, meaning that it could affect other areas of the body that are not directly affected by the medication. is applied directly.

This guide to medication provides details regarding Femring to treat some symptoms of menopausal women, which include hot flashes, the dryness of vagina burning, and irritation. Femring (systemic) is also used for reasons not mentioned in this medication guide.

Side effect of Femring:

Contact a medical professional immediately in the event that you exhibit symptoms that indicate an allergy, such as asthma, hives, and swelling of your lips, face, or tongue.

Take off the vaginal ring and seek immediate medical attention in the event of vomiting, nausea and muscle pain, diarrhea, fainting, dizziness, or a sunburn-like skin rash. These could be symptoms of a potentially fatal disease known as toxic shock syndrome.

Femring could result in serious adverse and unwanted side effects. Consult your physician immediately. If you suffer from:

  • Heart attack symptoms: chest pressure or pain; pain that spreads into your shoulder or jaw; vomiting; sweating;
  • Symptoms of a stroke—sudden weakening or numbness (especially for one leg) or sudden, intense headache or slurred speech difficulties with balance or vision;
  • Symptoms of a blood clot: sudden vision loss, stabbed chest pain, feeling tired, and coughing up blood. Heat or pain in both legs;
  • The tenderness or swelling of your stomach;
  • Jaundice (yellowing of the eyes or skin);
  • Memory problems and confusion, as well as unusual behavior;
  • Abnormal Vaginal bleeding and pelvic pain
  • An unidentified mass in your chest or
  • The calcium levels in your blood cause nausea, constipation, more thirst or urination, muscle weakness, bone pain, fatigue, and nausea.

Common adverse consequences of femring can include:

  • Nausea, vomiting, bloating, and stomach cramps;
  • Headache;
  • Tenderness or pain in the breasts;
  • Swelling of your feet or hands and feet; weight gain
  • Hair loss on the scalp
  • Vaginal irritation or discharge from your vagina; change in the menstrual period; breakthrough bleeding

This isn't an exhaustive list of possible side effects, and other side effects could occur. Consult your physician for advice regarding medical effects. You can report any side effects to the FDA at 1-800-FDA-1088.

Related drugs

Estradiol, Premarin, Estrace, Prempro, Vagifem, and Estrogel


It is not recommended to make use of Femring when you suffer from vaginal bleeding that is not diagnosed, the liver or an undiagnosed bleeding condition, or if you are planning to require significant surgery or have had an attack of the heart, stroke, blood clot, or cancer that affects the breast, uterus, cervical, or vagina. Don't use it if you expect it.

Estradiol could increase your chance of developing an illness that could result in cancer of the uterus. If you notice any bleeding from your vagina, immediately

Utilizing this medicine may increase the chance of developing blood clots, stroke, heart attack, or cancer of the uterus, breast, or ovaries. Estradiol should not be used to stop coronary heart disease, stroke, heart attack, or Alzheimer's disease.

Prior to use this drug

It is not recommended to use estradiol in the event that you are allergic to the chemical or suffer from any of the following:

  • Abnormal vaginal bleeding that hasn't been examined by an ophthalmologist;
  • Liver disease;
  • An occurrence or a history of stroke, heart attack, or blood clots;
  • An increased risk of getting blood clots because of a heart condition or hereditary blood disorder
  • A history of cancer related to hormones is also known as cancer of the uterus, cervix, breast, or vagina.

Do not take estradiol while you are expecting. Tell your doctor immediately if you become pregnant while receiving treatment.

The use of this medication can increase the risk of strokes, blood clots, and heart attacks. There is a higher risk if you suffer from elevated blood pressure, diabetes, high cholesterol, or if you're overweight or smoke.

Estradiol is not recommended to treat coronary heart disease, stroke, or dementia, as the medicine could actually increase the chances of developing these diseases.

Inform your doctor if you have ever suffered from:

  • Heart disease;
  • Jaundice, or liver issues resulting from pregnancy or taking hormonal medications;
  • Kidney disease;
  • Gallbladder diseases;
  • Asthma;
  • Epilepsy or another seizure disorder
  • Migraines;
  • Lupus;
  • Endometriosis or uterine fibroid tumors;
  • The hereditary type of angioedema;
  • Porphyria (a genetic disorder of the enzyme that results in symptoms affecting the nervous system or skin);
  • A thyroid disorder
  • Calcium levels that are too high are present in the blood.

Estradiol use can increase your risk of getting cancer of the uterus, breast, or ovaries. Consult your doctor about the possibility.

Estradiol reduces the hormone required for the production of breast milk. It can reduce the production of breast milk. Consult your physician if you are breastfeeding.

How to take Femring?

Follow the directions on the prescription label and also read all medication guides or instructions sheets. Make sure you use the medication precisely as prescribed. Cleanse your hands prior to and after inserting the vaginal rings.

It is unlikely that you will feel the vaginal ring when it's placed. The vaginal ring should remain on for 90 days before being removed. Your physician may advise you to change it into a brand new ring. The ring doesn't have to be removed when having a sexual encounter. If the ring causes discomfort, then you can remove it, rinse it with warm water, and return it to its place after your sexual encounter. To take the ring off, you need to loop your finger around the ring, then gently take it off the vagina. Contact your doctor if you are having difficulty removing a vaginal ring.

Estradiol can increase the chance of developing a condition that could lead to uterine cancer. Contact your doctor immediately when you notice any unusual vaginal bleeding after taking Femring.

Your doctor should examine your improvement regularly (every 3 to six months) to determine if you are able to continue with this treatment. Check the breasts to detect lumps and bumps on a regular basis, and get an annual mammogram when you are taking estradiol.

If you require major surgery or are being placed on a longer-term mattress, you might be required to stop taking the medicine for a short duration. Any surgeon or doctor who treats you should be aware that you're taking estradiol. Store the vaginal ring in its pouch until you are ready to use it. It should be kept at room temperature, far from heat and moisture.

What happens if I miss the dose?

Take off the vaginal ring and put in a new one whenever you remember. Do not put on an extra vaginal ring in order to make up the lost time.

If a vaginal band falls out, clean it off with warm water, then insert it back. If it slips down into the lower portion of the vagina, apply pressure with your fingers to push it back in further.

What happens if I overdose?

Get medical attention in an emergency or contact the Poison Help Line toll-free at 1-800-222-1222.

What should be avoided?

Don't smoke. It could greatly increase the chance of having a stroke, blood clots, or heart attack while taking estradiol. Do not use other vaginal products that aren't approved under the guidance of your physician. Grapefruit could interact with estradiol, leading to adverse side effects. Beware of using products made from grapefruit.

Interaction with other drugs

There are times when it's not recommended to take certain medicines simultaneously. Certain medications can alter the blood levels and the other medications you are taking, which could cause more side effects or make the medication less effective.

Many medications can impact estradiol. This includes over-the-counter and prescription medications, vitamins, and herbal supplements. The interactions between these products are not mentioned here. Inform your doctor of your current medications as well as any new medications you are about to start or stop taking.