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Excedrin Sinus Headache

Generic name: acetaminophen and phenylephrine [a-SEET-a-MIN-oh-fen-and-FEN-il-EFF-rin]

Brand names: Acetaminophen Congestion and Pain, Alka-Seltzer Plus Cold and Sinus, Excedrin Sinus Headache, Mygrex, Sudafed PE Pressure Plus Pain,… Show all 20 brands
Drug Class: Upper Respiratory Combinations

What is Excedrin Sinus Headache?

Acetaminophen can help relieve discomfort and lower fever.Phenylephrine shrinks the blood vessels of the nasal passages. Dilated blood vessels can cause congestion in the nasal passages.Excedrin Nasal Headache treats headaches, fevers, body aches, and sinus congestion due to allergies, the common cold, or the flu.Excedrin Sinus Headache can be used in other ways not mentioned in this medication guide.

Side effects of Excedrin Sinus Headache

Identify Symptoms of An Allergic Reaction If any of the following signs and symptoms indicate an allergic reaction: Hives, difficulty breathing or swelling in lips, face, tongue or throat are symptoms that should prompt immediate medical intervention:Acetaminophen can cause serious, life-threatening skin reactions even if taken previously without adverse side effects. Even taking multiple doses without experiencing a reaction could result in sudden death.

The medicine can cause serious side effects. If you experience:

  • Heart rate can be fast, slow, or uneven.
  • Confusion, hallucinations;
  • Tremor, seizure (convulsions);
  • Little or no urinating is acceptable.
  • Nausea; upper stomach pain; itching; loss of appetite; and dark urine or clay-colored stools. Jaundice.
  • Symptoms of dangerously high blood pressure include a severe headache, blurred or buzzing vision, anxiety, confusion, chest discomfort, shortness of breath, and seizures.

Side effects of Excedrin Sinus Headache include:

  • Dizziness, weakness;
  • Mild headache
  • Mild nausea, diarrhea, upset stomach;
  • Runny nose
  • Feeling nervous, restless, or anxious
  • Sleep problems (insomnia).

There may be other side effects. For medical advice on side effects, call your doctor. Contacting the FDA in regards to side effects is easy: simply dial 1-800-FDA-1088!


You should not take this medication if you've taken an MAO inhibitor in the last 14 days. A dangerous drug interaction may occur. MAO inhibitors are isocarboxazid (linezolid), phenelzine (rasagiline), selegiline (tranylcypromine), and rasagiline.Don't take more than recommended. An acetaminophen overdose can cause liver damage or death.Acetaminophen can cause severe skin reactions in rare cases. If you notice skin redness, a rash, or blisters that are peeling off and spreading, stop taking the medicine immediately and contact your doctor.

Before you take this drug

If you have an allergy to acetaminophen or phenylephrine (Tylenol), then you should not take Excedrin Sinus Headache.If you have taken a MAO inhibitor within the last 14 days, do not take this medication. It is possible that a dangerous drug interaction will occur. MAO inhibitors are isocarboxazid (linezolid), phenelzine (phenelzine), rasagiline (selegiline), and tranylcypromine.If you have any other medical conditions or concerns, ask your doctor or pharmacist whether it's safe to take the medicine.

  • Liver diseases; cirrhosis; a history of alcoholism; or if you consume more than three alcoholic drinks per day.
  • High blood pressure, coronary heart disease
  • Overactive thyroid
  • Pheochromocytoma
  • If you are taking an antidepressant,

Excedrin Sinus Headache is not known to harm an unborn child. If you are pregnant, do not take cough and cold medicines without consulting your doctor.Acetaminophen, phenylephrine, and other drugs can pass through breast milk. This may cause harm to a nursing infant. Decongestants can also reduce breast milk production. If you are pregnant, do not take cough and cold medicines without consulting your doctor.

Do not give children under the age of five any cough or cold medicine.

How to take Excedrin Sinus Headache?

Do not exceed the recommended dosage. Use only as directed. Cold medicines are usually only taken for a few days until symptoms disappear.Don't take more than recommended. Acetaminophen overdoses can cause liver damage or death.One packet of powder should be dissolved in 4 ounces or more of water. Mix this mixture well and consume it immediately.Drop the effervescent tablet into a glass full of water (at least 4 ounces or half a cup). This mixture should be stirred and consumed immediately.If you continue to have symptoms after three days, or you experience pain for seven days (or five days if treating children), or you develop a skin rash or persistent headaches, or you notice any redness or swelling, stop taking the medication and contact your doctor.Tell your doctor or surgeon, if you've taken this medication within the last few days, if you are going to need medical testing or surgery.Store away from heat and moisture at room temperature.

What happens if I miss the dose?

You may not have a schedule for taking Excedrin Sinus Headache, as it is taken only when necessary. Take the missed dose immediately if you take the medication regularly. If your next scheduled dosage is near, skip the missed dose. You should not take more medicine to compensate for a missed dose.

What happens if I overdose?

Call the Poison Help Line at 1-800-222-1222 or seek emergency medical care. Acetaminophen overdoses can be deadly.Loss of appetite, nausea and vomiting, sweating, and confusion or weakness are the first signs. Other symptoms include dark urine and yellowing skin or whites of the eyes.

What should be avoided?

This medication can affect your ability to think or react. You should be careful when driving or doing anything else that requires you to remain alert.Before using any other pain reliever, allergy medicine, or sleep medicine, consult your doctor or pharmacist. Many combination medications contain acetaminophen, also known as APAP. Taking some products together may cause an overdose of acetaminophen, which could be fatal.Avoid alcohol. Acetaminophen can increase the risk of liver damage.

Interaction with other drug

Other drugs, such as vitamins and herbal products, may also interact with acetaminophen or phenylephrine. Inform your healthcare providers of all the medicines you are taking and those you plan to take.