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Estradiol and Norethindrone (Transdermal)

Generic name: estradiol and norethindrone (transdermal) [ES-tra-DYE-ol-and-nor-ETH-in-drone]

Brand name: Combipatch
Form of dosage: Transdermal Film, Extended Release (0.05-0.14 mg/24 h; 0.05-0.25 mg/24 h)
Class of drugs: Combinations of sex hormones

What is Estradiol and Norethindrone (Transdermal)?

Estradiol combined with norethindrone is used for the treatment of menopause-related symptoms, such as vaginal changes and hot flashes. Estradiol or norethindrone can also be used to treat menopause symptoms such as hot flashes and vaginal changes.This medication guide does not list all possible uses of estradiol or norethindrone.

Side effects of  Estradiol and Norethindrone (Transdermal)

If you experience any of the following symptoms of an allergy reaction, seek immediate medical attention: difficulty breathing, hives, swelling in your lips, face, throat, or tongue.

If you suffer from:

  • Heart attack symptoms: chest pain, pressure or pain in your shoulder or jaw, nausea, and sweating.
  • Increased blood pressure can cause a severe headache or blurred vision. It may also lead to a pounding sensation in the neck, ears, and head; anxiety;
  • Signs of a stroke: sudden numbness, weakness, or headache (especially on one side), slurred or mumbled speech, or problems with balance or vision;
  • Signs of blood clots: sudden vision loss, chest pain that stabs, shortness of breath, blood in the cough, or pain or heat in both legs
  • You may experience swelling in the stomach or tenderness.
  • Jaundice
  • Breast lumps;
  • Memory problems, confusion, or unusual behaviors;
  • High levels of calcium are accompanied by nausea, vomiting, and constipation. Other symptoms include muscle weakness, pain in the bones, fatigue, or increased thirst.

Some of the common side effects associated with estradiol or norethindrone include:

  • Nausea, vomiting, stomach cramps;
  • Bloating, swelling, and weight gain
  • Breast pain
    light vaginal bleeding;
  • Vaginal itching or discharge
  • Headache;
  • Hair loss on the scalp
  • Redness or irritation at the site of wearing the patch

There may be other side effects. For medical advice on side effects, call your doctor. Report side effects by calling the FDA at 1-800-FDA-1088.


Estradiol or norethindrone shouldn't be taken to treat strokes or dementia.

Before you take this drug

This medicine should not be used if:

  • Unusual vaginal bleeding not checked by your doctor
  • Liver Disease
  • A bleeding disorder;
    A history of heart attacks, strokes, or blood clots;
  • A history of (hormone-related) cancer or of cancers of the breast, uterus, cervix, or vagina

If you've had your uterus removed, do not take estradiol or norethindrone.If you're pregnant, do not take estradiol or norethindrone. Inform your doctor immediately if a pregnancy occurs during treatment.This medicine increases your risk of blood clots and strokes. This medicine can increase your risk of blood clots, strokes, and heart attacks.This medicine can actually increase the risk of heart disease, stroke, or dementia.

If you've ever:

  • Heart disease
  • Liver problems
  • Kidney disease
  • Angioedema is swelling of the face and tongue.
  • Lupus;
  • Asthma;
  • Diabetes;
  • Epilepsy
  • Migraines;
  • Porphyria
  • Gallbladder Disease
  • Endometriosis;
  • High calcium levels;
  • A thyroid disease;
  • If you experience any abnormal vaginal bleeding,

Estradiol or norethindrone can increase the risk of breast cancer, uterine cancer, and ovarian carcinoma. Speak to your doctor regarding this possibility.A doctor can tell you if breastfeeding is possible while taking this medication.

How to take Estradiol and Norethindrone (Transdermal)?

Read all the instructions or guides that come with your medication and follow all the directions. Follow the directions on your prescription label.Please read and follow all instructions for use that come with your medication. If you don't understand the instructions, ask your pharmacist or doctor.You may have to temporarily stop taking estradiol or norethindrone if you are going through a major operation or if you will need to be bed-ridden for an extended period of time. You should let any doctor that treats you know that you use estradiol or norethindrone.You should have your doctor check on you regularly to see if this is a treatment that should be continued. You should self-examine for lumps in your breasts every month and get regular mammograms when using estradiol or norethindrone.Do not freeze estradiol or norethindrone. Let the medication reach room temperature by removing it from the fridge.

What happens if I miss the dose?

Follow your normal schedule to change the patches. Apply two patches separately.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

What should be avoided?

Smoking is harmful. While using norethindrone and estradiol, your chances of getting a stroke or heart attack, as well as blood clots, are increased.Avoid grapefruit products, as they may cause unwanted side effects. Use grapefruit-based products as little as possible.If you use creams or lotions to apply your patch, it might not adhere.

Interaction with other drug

It is sometimes not a good idea to take certain drugs at the same time. Some medications can cause side effects that increase or decrease the effectiveness of another drug you are taking.Estradiol or norethindrone may be affected by other drugs, such as prescription medicines, over-the-counter medications, vitamins, and herbal products. Inform your doctor of all the other medications you take.