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Esterified Estrogens and Methyltestosterone

Generic name:Esterified estrogens and methyltestosterone [ess-TER-ih-field ESS troe jenz and METH il TOS te rone]

Brand names: Covaryx, Covaryx HS, EEMT, EEMT HS and Estratest… Here is a complete list of 13 brands.
Oral tablet: (0.625–1.25 mg; 1.25-2.25mg)
Class of drugs: Combinations of sex hormones

What are Esterified Estrogens and Methyltestosterone?

Esterified estrogen is a female sexual hormone that's produced by the ovaries.Methyltestosterone is a sexual hormone produced by a male's testicles. Testosterone is also found in small amounts within the adrenal glands and ovary of women.The combination of esterified estrogens with methyltestosterone can be used to treat symptoms associated with menopause, such as night sweats. Esterified estrogens and methyltestosterone are usually only given for a short time (such as three to six months).This medication guide does not list all possible uses for esterified esters and methyltestosterone.

Side effects of  Esterified Estrogens and Methyltestosterone

If you experience symptoms of a severe allergic reaction, such as hives or difficulty breathing or swelling on your face, throat, or nose, or an extreme skin reaction, including burning eyes or skin, fever, blistering or peeling skin, or skin pain or redness, seek emergency medical attention.

Side effects from methyltestosterone and esterified estrogens can be serious. If you experience:

  • Heart attack symptoms: chest pain, pressure or pain in your shoulder or jaw, nausea, and sweating.
  • Signs of a stroke: sudden numbness (especially on one side), severe headache; slurred or shaky speech.
  • Signs of blood clots: sudden vision loss, chest pain that stabs, shortness of breath, blood in the cough, or pain or heat in both legs.
  • You may experience swelling in the stomach or tenderness.
  • Nausea, vomiting, swelling, and rapid weight gain;
  • Jaundice
  • Changes in the skin's color
  • A feeling of lightheadedness, as if you could pass out.
  • Unusual vaginal bleeding
  • Breast lumps;
  • Memory problems, confusion, and unusual behaviors;
  • High levels of calcium are accompanied by nausea, vomiting, constipation, or increased thirst and urination. Other symptoms include muscle weakness, pain in the bones, or a lack of energy.

A woman who takes methyltestosterone may develop symptoms that are male in nature. These include enlarged genitals and male-pattern hair loss. Other signs can be increased body hair, acne, or irregular periods.

Side effects associated with esterified esters and methyltestosterone include:

  • Breasts that are swollen, painful, or swollen
  • Bleeding, vaginal irritation, or discharge; changes to your menstrual cycle; the appearance of a breakout.
  • Pain or burning after urinating;
  • Nausea, vomiting, stomach cramps;
  • Darkening facial skin, hair growth and loss of hair on the scalp
  • Contact lenses can cause vision problems.
  • Weight gain, swelling, or weight loss.
  • Increased or decreased libido
  • Headache, dizziness, depression, anxiety,
  • Abnormal liver function tests

There may be other side effects. For medical advice on side effects, call your doctor. Report side effects by calling the FDA at 1-800-FDA-1088.


Do not use esterified esters and methyltestosterone in the event that you suffer from: severe liver diseases; if major surgeries are planned; or if you've had a stroke or blood clot.

Avoid using it if pregnant or nursing.

Estrogens can increase the risk that you develop a condition that may eventually lead to cancer of the uterus. Do not ignore any abnormal vaginal bleeding.Heart disease should not be prevented by using estrogens.

Before you take this drug

If you are:

  • Unusual vaginal bleeding not checked by your doctor
  • Severe liver disease
  • If you've had an ischemic stroke or blood clot,
  • If you've had cancers of the breast, uterus, cervix, or vagina, or if your cancer was hormone-related
  • If you're pregnant or nursing,

Avoid using this medication if pregnant. Inform your doctor immediately if you are pregnant while on treatment.This medicine increases your risk of blood clots and strokes. This medicine can increase your risk of blood clots, strokes, and heart attacks.The use of methyltestosterone and esterified estrogens to treat heart disease is not recommended. These drugs may increase the risk of these diseases.

If you've ever:

  • Heart disease
  • If you have liver disease or jaundice due to pregnancy, taking hormones, or being pregnant,
  • A thyroid condition;Gallbladder Disease
  • Kidney disease
  • Asthma;
  • Epilepsy
  • Migraine headaches
  • Diabetes;
  • Depression;
  • Fibroid tumors of the uterus;
  • A breast lump, abnormal mammogram,
  • Porphyria

This medicine can increase the risk of developing cancers of the breast, uterus, or vagina. Speak to your doctor about the risk.Breastfeeding may be unsafe while taking this medication. You should ask your doctor if there are any risks.

How to take Esterified Estrogens and Methyltestosterone?

Read all the instructions or guides that come with your medication and follow all the directions. Follow the directions on your prescription label.Esterified estrogens, or methyltestosterone, are usually taken for 3 weeks and then for 1 week. Please follow your doctor's advice.Estrogens can increase the risk that you will develop a condition that may eventually lead to uterine carcinoma. Do not ignore any abnormal vaginal bleeding.You may have to temporarily stop taking this medication if you are going to be undergoing major surgery or confined for long periods of time. You should let any doctor who treats you know if you use esterified esters and methyltestosterone.You should have your doctor check on you regularly to see if this is a treatment that should be continued. You should self-examine for lumps in your breasts every month and get regular mammograms while on esterified esters and methyltestosterone.Follow your doctor's advice about reducing your dosage when you stop taking this medication.Keep away from heat and moisture. Store at room temperature.

Details on dosage

Adult dosage for postmenopausal symptoms:

Esterified estrogens: medroxyprogesterone 1.25 mg–2.5 mg oral tablets: one tablet orally once a day
You can also find out more about
Esterified estrogens-medroxyprogesterone 0.625 mg-1.25 mg oral tablets: one or two tablets orally once a day
Women with uteri are advised to receive progestins in order to lower the risk of endometrial cancer.
The lowest dosage that controls symptoms in the shortest time frame is consistent with the treatment goal. Attempts to stop or reduce medication at intervals of 3 to 6 months are recommended.
There is no proof that estrogens can treat nervous symptoms and depression without causing vasomotor symptoms. Therefore, they should not be prescribed to treat these conditions.
Use: To treat moderate-to-severe vasomotor-symptomatic menopause symptoms in women who are not helped by estrogen alone.

What happens if I miss the dose?

If you are almost due for the next dose, skip the missed one. Never take multiple doses at the same time.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.Nausea and bleeding may be symptoms of an overdose.

What should be avoided?

Share esterified esters and methyltestosterone only with those who have similar symptoms to you.

Interaction with other drug

Inform your doctor of all other medications you are taking, including:

  • Insulin;
    A blood thinner: Warfarin Coumadin Jantoven

The list below is not exhaustive. This list is not complete. This list does not include all interactions with other drugs.



Prescription only

Pregnancy & Lactation

CSA Schedule*
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