What is Enfortumab Vedotin?
Enfortumab vedotin can be utilized to treat bladder cancer of the urinary tract and bladder in patients who have spread to various regions within the human body (metastatic) or can't be removed through surgical intervention.Enfortumab vedotin is typically used in conjunction with other treatments, like immunotherapy or platinum cancer medicines, or when you are not able to receive platinum cancer treatment.Enfortumab is also used for reasons not mentioned in this guideline.
Enfortumab Vedotin side effects
See a doctor immediately. If you are experiencing symptoms that indicate an allergic reaction, like hives, trouble breathing, or swelling of your lips, face, and throat,Enfortumab vedotin may cause severe and potentially life-threatening skin conditions. Seek medical attention immediately in the event of a growing skin rash, which is itchy and peeling skin lesions that appear like rings, flu-like or fever-like symptom glands that are swollen, painful sores on your nose, mouth, throat, and genital region.
Contact your doctor immediately. If you experience symptoms of elevated glucose levels:
- Increased drinking, dry mouth, odor of fruity breath;
- Increased urination
- Blurred vision blurred vision, confusion, sleepiness,
- Nausea, vomiting, stomach discomfort, and loss of appetite.
Make sure to contact your doctor at any time if you suffer from:
- Tingling, numbness, or muscle weakness in your feet or hands
- A new or worsening cough, breathing problems, or breath shortness;
- Irritation, redness, as well as peeling of the skin on the feet and hands;
- Extremely dry eyes, visual issues;
- Swelling, itching, redness, or pain in the area where the medicine was injected
- Low blood cell counts—fever chills, fatigue, skin sores, mouth sores, easily bruising, unusual bleeding, pale skin, cold feet and hands, and feeling lightheaded or out of breath.
The treatment you receive for cancer could be delayed or discontinued permanently in the event of certain negative side effects.
Common adverse effects of enfortumab could be:
- High blood sugar;
- Numbness or tingling
weakness in the muscles; - Low blood cell count;
- Fatigue;
- Nausea, diarrhea;
- Loss of appetite appetite loss, weight gain;
- Dry skin, itching
- Changes in your sense of taste
- Hair loss;
- Blood tests that are abnormal.
This list does not represent all possible side effects; other side effects could occur. Please consult your physician to seek medical advice regarding adverse reactions, or call the FDA directly at 1-800-FDA-1088 if any adverse reactions arise.
Similar/related drugs
Keytruda, Pembrolizumab, Nivolumab, Opdivo, Trodelvy, and Avelumab
Warnings
This medicine could cause a severe or even life-threatening eruption. Get emergency medical assistance if you experience an increasing rash that is itchy and peeling, blistering skin lesions that appear like rings, flu-like or fever-like symptom glands that are swollen, or painful sores that appear in your nose, mouth, throat, or genital area.
Before you take this drug
Inform your doctor if you were ever diagnosed with:
- Your feet and hands may experience numbness or tingling sensations that cause them discomfort, leading to possible nerve damage.
- Diabetes;
- High blood sugar
- The liver condition.
Enfortumab vedotin could harm an unborn child when the father or mother is taking enfortumab vedotin.
- If you're female, you may need an ultrasound test to be sure that you're not pregnant. Make sure you use contraceptives during the course of this medicine and at least for 2 months after the last dose.
- If you're male, use birth control when your partner in sex is likely to become pregnant. Continue using birth control for a minimum of 4 months following your last dose.
- It could be more difficult to induce pregnancy if you're taking this medication. It is still recommended to utilize birth control to avoid pregnancies because this medicine could cause harm to a baby who is not born.
- Contact your doctor immediately in the event of a pregnancy.
Avoid breastfeeding while taking this medication, and at least 3 weeks following your last dose.
How to take Enfortumab Vedotin
Enfortumab is injected into the vein by a healthcare professional.This medication must be administered slowly, over a period of 30 minutes.Contact your physician. If you experience any burning or pain after the enfortumab vedotin injection is administered,Enfortumab is administered over the course of a 28-day treatment. The injection will be given only on certain days during this treatment cycle. Your doctor will advise you on the number of cycles you will require.This medicine may cause a serious or even life-threatening rash, which is more likely to occur in the initial treatment. Contact your doctor immediately in the event of an outbreak of a new skin rash with itching that becomes more severe.Enfortumab can trigger hyperglycemia in the blood, even if you've never experienced it before or even if you're not diabetic. Hyperglycemia that is severe could be life-threatening. Your blood sugar levels may require frequent testing.Enfortumab Vedotin may also trigger dry eyes. Your doctor might advise you to apply artificial teardrop eye drops to prevent dry eyes.
Details on dosage
Usual Adult Dose for Urothelial Carcinoma:
1.25 mg/kg (up to 135 mg for patients who weigh 100 kg or more) Injection for 30 minutes on Days 1, 8, and 15 of a 28-day course
Duration Time: Until progression of the disease or unacceptably toxic
Comment:
Combination therapy with Pembrolizumab is granted accelerated approval based on the tumor response rate and the duration of the response.
Use:
To treat adults with metastatic or locally advanced urothelial cancer (mUC) patients who
Have previously received a programmed death receptor 1 (PD-1) or programmed Death-Ligand 1 (PD-L1) inhibitor or a chemotherapy containing platinum?
Are not eligible to receive the cisplatin-containing chemotherapy. They have also had one or more treatments.
Together with pembrolizumab to treat adult patients suffering from metastatic or locally advanced urothelial cancers that aren't suitable for chemotherapy with cisplatin.
What happens if I miss the dose?
Consult your physician for treatment. If you do not make an appointment for the enfortumab injection,
What happens if I overdose?
In a medical facility, an overdose could be immediately treated.
What should be avoided?
Follow the instructions of your physician regarding any restrictions on your food, drink, or activities.
Interaction with other drug
A variety of drugs may affect the blood levels of enfortumab vedotin. This could increase the risk of the effects of your medication. Inform your doctor about any other medications you are taking, which include prescription and non-prescription medications, vitamins, and herbal remedies. The interactions of all drugs are not mentioned here.
