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What is Embeda?
Embeda includes a mix of morphine and naltrexone. Morphine is an opioid painkiller. A drug called an opioid can be described as a drug called a narcotic. Naltrexone can block certain effects of opioids, such as feelings of wellbeing, that could lead to their use.Embeda can be used to treat moderate to extreme pain in cases where continuous pain relief is required for an extended period of time. Naltrexone is a component of this medicine to avoid abuse of this narcotic component.Embeda is a long-release opioid pain medication that is not intended to be used on a limited basis to treat pain.
Side effects of Embeda
Take immediate medical assistance. If you exhibit symptoms of an allergic reaction, Embeda symptoms include difficulty breathing or chest pain, anxiety, heartbeat pounding, loss of consciousness, and swelling of your lips, face, and tongue.Opioid medication can stop or slow your breathing and even cause death. A person caring for you must seek urgent medical care if you suffer from breath that is slow, with pauses for long periods or blue-colored lips, or if it is difficult to get up.
Contact your doctor immediately for:
- Breathing that is weak or shallow and ceases during sleeping;
- An euphoric feeling, similar to you're passing out;
- Seizure (convulsions);
- Low levels of cortisol, nausea, dizziness, loss of appetite, fatigue, or worsening weakness.
You should seek medical attention immediately if you experience signs of serotonin-related syndrome, like hallucinations, agitation, sweating, fever, and shivering. You may also experience a rapid heart rate, stiffness of muscles, or twitching. Also, you may experience loss of coordination, nausea, vomiting, or diarrhea.Risky side effects are more likely to occur in older patients and people who are obese or malnourished.The long-term use of opioids can impact fertility (the ability to have kids) for women or men. It is unclear if the effects of opioids on fertility are permanent.Common Embeda side effects can include:
- Constipation, nausea, vomiting, and stomach pain;
- Drowsiness, dizziness,
- Fatigue, headache.
This isn't an exhaustive list of possible side effects, and other side effects could occur. Consult your physician to seek medical advice on adverse effects. You can report any side effects to the FDA at 1-800-FDA-1088.
Warnings
Morphine can cause breathing to slow or stop, and it can cause a habit. The misuse of embeda can result in addiction, overdosing, or even death. Keep the medication at a distance from where others are unable to access it.Do not take Embeda when you've taken any MAO inhibitor within the last 14 days, including isocarboxazid or linezolid, blue injection, or phenelzine rasagiline, selegiline, or tranylcypromine.
Embeda Embeda during pregnancy can result in life-threatening withdrawal symptoms for the baby.The risk of fatal side effects could be experienced if you take the medicine in conjunction with alcohol or with other medications that can cause drowsiness or slow the rate of breathing.
Before you take this drug
Do not take Embeda when you've taken an MAO inhibitor within the last 14 days. A potentially dangerous interaction with a drug could occur. MAO inhibitors include isocarboxazid linezolid, methylene blue injection rasagiline, phenelzine, and tranylcypromine, among others.It is not recommended to make use of Embeda. If you've ever experienced an allergic reaction to an opioid medication or
- Serious asthma or breathing problems. Severe asthma or breathing problems.
- An obstruction of the bowel known as paralytic ileus.
To be sure Embeda is suitable for you, ask your doctor if you've ever been:
- Breathing issues sleep apnea
- An injury to the head, seizures, or brain tumors;
- Addiction to alcohol or drugs or mental illness.
- Prostate enlargement, urinary problems;
- Kidney or liver disease
- Issues with your gallbladder, thyroid gland, pancreas, or adrenal gland;
- An abnormal curvature of your spine, which affects the way you breathe.
Check with your physician whether you are also taking stimulant medications, opioid medicines, herbal products, or medicines to treat mental illness, such as depression, such as Parkinson's disease, migraines, severe infections, headaches, or for the prevention of vomiting and nausea. These medicines can be in a relationship with naltrexone and morphine and trigger a severe condition known as serotonin syndrome.If you take morphine during pregnancy, your baby may become dependent on this drug. This can cause severe withdrawal symptoms for the infant after it is born. Babies who become dependent on the habit-forming drug could require medical care for a period of time.Avoid breastfeeding when using Embeda. Morphine and Naltrexone may enter breast milk, causing breathing difficulties, drowsiness, or even death for the nursing infant.
Similar or related drugs
aspirin, acetaminophen, tramadol, duloxetine, naproxen, oxycodone, and tylenol
How to take Embeda?
Use Embeda exactly as it is prescribed. Follow the directions on the prescription label and go through the entire medication guide. Don't make use of Embeda in higher doses or for a longer period than the prescribed.to Tell your doctor when the medication seems to cease working to relieve discomfort. Inform your doctor if you notice an increase in the desire to take more of this medication.Stop taking any other prescription painkillers once you begin taking Embeda.
Morphine could be a habit-forming drug even in regular doses. Don't share this medication with anyone else, particularly those who have a history of addiction or abuse. Misuse of narcotic medications can lead to addiction or even death, particularly in children or any other person who is using the medication without a prescribed prescription. Selling or giving away Embeda is illegal.It is possible to consume Embeda either with food or without.
breaking,Avoid crushing, breaking or tearing open the extended-release Embeda capsule. Take the capsule whole to be safe from exposure to a potentially fatal dose. Never open the Embeda capsule in order to breathe the powder, or mix it with a liquid that allows you to inject the drug into the vein. This can cause death.
If you are unable to swallow a capsule with extended release completely, open the capsule and then sprinkle the medicine over an applesauce spoonful. Mix just one dose and take the mixture away without chewing. Drink an ounce of water to ensure that all of the medication has been absorbed. Clean the capsule completely in the toilet.Don't stop taking Embeda abruptly; otherwise, you might experience uncomfortable withdrawal effects. Discuss with your physician how you can effectively stop using the medicine.Keep at room temperature, free of heat, moisture, and light. Be sure to keep track of your medication. Morphine is a drug that can cause misuse, and you must be aware of anyone using the medicine in a way that is not legal or without a prescription.Don't keep any empty bottles of opioids. A single dose could cause death if someone is using the medication in error or incorrectly. Ask your pharmacist for a disposal program. If there isn't a taking-back system, then flush any remaining medicine down the drain.
Details on dosage
Usual Adult Dose for Chronic Pain:
The following recommendations for dosing can be considered a way to make what's actually a sequence of clinical choices over time to manage the individual patient.
All doses are expressed as MORPHINE/NALTREXONE.
Use as the primary opioid analgesic or for those who are not opioid-tolerant.
Initial dosage starting at 20 mg/0.8 mg taken orally every 24 hours
CONVERSION FROM OTHER OPIOIDS:
Discontinue all other opioids that are available 24/7.
Start with 30 mg/1.2 mg daily, orally for 24 hours.
CONVERSION FROM OTHER ORAL MORPHINE FORMULATIONS:
Give one-half of the total daily morphine dose orally every 12 hours, or administer the entire daily dose of morphine orally at least once a day.
CONVERSION FROM PARENTERAL MORPHINE OR OTHER OPIOIDS:
If you are converting from morphine that is parenteral, one mg of parenteral or oral morphine is equivalent to about 2 to 6 mg of oral morphine. The typical oral morphine dose is three times the daily dose of parenteral morphine.
If you are converting from another opioid (parenteral or oral), when converting from other opioids: The initial dose of morphine and naltrexone must be half of the daily morphine intake. control insufficient analgesia by supplementing it with immediate-release morphine.
CONVERSION FROM METHADONE:
Methadone's half-life is long and is able to accumulate in the plasma. The ratio between other opioid agonists and methadone can vary greatly. Monitoring closely is important.
MAINTENANCE DOSAGE: Individually adjust to a dose that gives sufficient analgesia and reduces the risk of adverse reactions. Adjustments to the dose can be made every 1 or 2 days.
BREAKTHROUGH PAIN In the event that the degree of pain increases following the stabilization of the dose, try to determine the cause prior to increasing the dose.
A medication for rescue that has appropriate analgesia with immediate release could be beneficial.
For patients who experience inadequate analgesia after a daily dose, a twice-daily regimen could be suggested.
Comments:
A patient who is opioid-tolerant will be one who's received at the very least oral morphine for 60 mg/day, a transdermal fentanyl patch with 25 mg per hour, 30 mg of oral oxycodone per day, oral hydromorphone, 8 mg/day, oral oxymorphone, 25 mg/day, or an equivalent dose of a different opioid.
The capsules with 100 mg and 4 mg are intended for those who are opioid-tolerant.
Watch patients closely for signs of respiratory depression, particularly during those first 24-72 hours following beginning therapy.
The initial dose of this drug can be taken along with the final dose of any opioid with immediate release because of its extended-release properties.
Use: To manage the effects of severe pain enough to warrant daily, 24/7, long-term opioid therapy and for which other treatment options aren't sufficient.
What happens if I miss the dose?
Because Embeda is a painkiller, it is unlikely to skip the dose. Do not miss any doses in the event that it is near the time for your next scheduled dose. Don't take extra medication to make up for the missed dose.
What happens if I overdose?
For medical emergencies, seek immediate attention. You can also contact emergency medical attention or call the Poison Helpline at 1-800-222-1222. An Embeda overdose could be fatal, particularly in children or another user of the medicine without a prescription. Overdose symptoms may include a slow heart rate and severe drowsiness. Other symptoms include weakening muscles, clammy and cold skin, eyes that are slit, breathing that is very slow, or a coma.
What should be avoided?
Don't drink or consume alcohol. Dangerous side effects or even death may occur if alcohol is mixed with Embeda.The medication could affect your ability to think or react. Avoid operating machinery or driving until you are aware of how Embeda affects your body. Drowsiness, dizziness, or confusion can lead to accidents, falls, or serious injuries.
Interaction with other drug
Opioid medicine may interact with other medications, causing deadly side effects or even death. Be sure your doctor is aware if you are taking:
- Other narcotic drugs, such as opioid pain medicine and prescription medicine for cough
- An sedative similar to valium (also known as diazepam, alprazolam, lorazepam, ativan, klonopin, restoril, tranxene, versed, xanax, and other sedatives);
- Drugs that can make you restless or cause breathing to slow (a sleep pill, muscle relaxer or tranquilizer, an antidepressant or antipsychotic medicine);
- Medications that alter serotonin levels within your body as a stimulant or medication for parkinson's disease, depression, migraine headaches, severe infections, or to prevent vomiting and nausea.
This list isn't complete. Other medications can interact with naltrexone or morphine, such as prescription and over-the-counter medications, vitamins, and herbal supplements. There are not all interactions included in this guideline for medication.