The Web Health

Subscribe

Elahere

Generic name: Mirvetuximab Soravtansine [MIR-ve-TUX-i-mab-SOE-rav-TAN-seen]

Drug class: miscellaneous antineoplastics Medically examined with Judith Stewart, BPharm. The last update was on March 17, 2023.

What is Elahere?

Elahere is an anti-drug conjugate that targets folate receptor alpha (FRa), the surface protein found in cells that is frequently expressed in cancer of the ovary.Elo Here is a prescribed medicine for adults suffering from ovarian cancer or the fallopian tube, as well as secondary peritoneal carcinoma, who are no longer responding to chemotherapy based on platinum and have had one to three different types of chemotherapy.Your doctor will run a test to ensure that Elahere is the correct option for you.It isn't known whether Elahere is safe or efficient for children.

Side effects of Elahere

See a doctor immediately in the event that you exhibit symptoms of an allergic reaction or a reaction such as symptoms of hives, difficulty breathing, or swelling of your lips, face, and tongue.

Elahere could cause serious adverse effects. Contact your doctor immediately. If you suffer from:

  • Dry eyes, light sensitivity, blurred vision, eye pain, or more severe or new vision problems;
  • Cough, chest pain, trouble breathing, a shortness of breath
  • Tingling, numbness, or burning pain in your hands and feet

Common Elahere adverse effects could include:

  • Abnormal lab results;
  • Nausea, stomach pain, constipation, constipation;
  • Fever, mouth sores, open sores in the skin, a sore throat, cough
  • Dull skin and fatigue; feeling lightheaded or tired; cold feet and hands

This list does not constitute an exhaustive listing of side effects; other side effects could occur and should be reported directly to your physician and the FDA at 1-800-FDA-1088.

Warnings

Consult your physician immediately. If you are experiencing any eye issues, such as blurring of vision, eye discomfort, or any new or recurring eye problems,

Before you take this drug

To ensure that Elahere is suitable for you, inform your doctor if you've ever experienced:

  • Problems with vision or eyes vision or eye problems
  • Liver issues.

Elahere could harm an unborn baby. Avoid using it if you are expecting. Make sure you use an effective birth control method while taking Elahere for at least seven months following your last dose. Inform your doctor if you become pregnant.It is possible that you will need to take a pregnancy test that is negative prior to commencing this treatment.Avoid breastfeeding while taking this medicine and for a minimum of 1 month after the last dose.

How to take  Elahere?

Elahere can be administered as an injection into the vein. Follow the instructions on the prescription label, and study all medication guides or instructions sheets.Your doctor could alter the way you are treated, delay, or stop Elahere's treatment when you have a history of adverse reactions.Where is usually administered every three weeks as an infusion into the vein. Your physician will decide the number of cycles you'll need.You might also be prescribed additional medications to help you avoid adverse side effects or allergic reactions. Continue taking these medications for the duration your doctor prescribes.You might require frequent examinations of your vision.Your doctor might prescribe eye drops prior to and during treatments with Elahere. It is recommended to use the eye drops according to instructions given by your physician.

Details on dosage

Usual Adult Dose for Ovarian Cancer:Usual dosage 6 mg/kg of adjusted ideal body mass (AIBW) in an IV infusion every three weeks.
The duration of treatment is until the disease progresses or becomes unacceptably toxic.

Usual Adult Dose for Fallopian Tube Cancer:Usual dosage: 6 mg/kg, adjusted for weight (AIBW) in an IV infusion every 3 weeks.
The duration of treatment is until the disease progresses or if there is unacceptable toxicity.

Usual Adult Dose for Peritoneal Cancer:Usual dosage: 6 mg/kg, adjusted for body mass (AIBW) in an IV infusion every 3 weeks.
The duration of treatment: Until the progression of the disease or unacceptably toxic

Comments:
These indications have received expedited approval based on cancer response rates and duration of responses. The continued approval of this indication is contingent upon confirmation and explanation of clinical benefits during a confirmatory study.
Verify the presence of folate receptor alpha tumors prior to the beginning of treatment.
Information regarding FDA-approved tests for folate receptor alpha tumors is available at http://www.fda.gov/CompanionDiagnostics.
Refer to the manufacturer's product details to determine the AIBW calculation.
Premedications should be administered (corticosteroid, antihistamines, and antipyretics, as well as antiemetic) prior to every infusion of this medication to lessen the likelihood of severe infusion-related reactions (IRRs) such as nausea and vomiting.
Refer to the labeling on the product of the manufacturer for further information regarding the dosage of prescription medications.
Patients who have platinum-resistant epithelial fallopian tube, ovarian, or primary peritoneal tumors with folate receptor alpha-positive tumors who previously had one to three lines of systemic treatment

What happens if I miss the dose?

Contact your doctor for advice. If you do not make an appointment to receive an appointment for an Elahere injection,

What happens if I overdose?

In a medical environment, an overdose could be taken care of quickly.

What should be avoided?

Do not wear contact lenses when taking Elahere unless your doctor recommends it.

Interaction with other drugs

Discuss with your doctor all the medications you take. Certain drugs may be incompatible with mirvetuximab and soravtansine, specifically:

  • Nefazodone;
  • Cancer medicine: ceritinib, idelalisib, ribociclib, and tucatinib;
  • Is an antibiotic antibiotic, clarithromycin, telithromycin;
  • Antifungal medicine: itraconazole, ketoconazole, posaconazole, voriconazole
  • Antiviral medication to treat hiv and hepatitis c boceprevir, cobicistat, dasabuvir, and indinavir; elvitegravir; lopinavir/r; and nelfinavir. Also known as ombitasvir. Paritaprevir, saquinavir, indinavir, and tel tipranavir.

The list below isn't exhaustive, and a variety of other medications could be incompatible with mirvetuximab and soravtansine. This includes prescription and over-the-counter drugs, vitamins, and herbal supplements.There is a variety of drugs that could be utilized.

DRUG STATUS

Availability

Prescription only

Pregnancy & Lactation

CSA Schedule*
Related Drugs
Related Stories

Images