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Doravirine

Generic name: Doravirine [DOR-a-VIR-een]

Brand names: Pifeltro
Drug class: NNRTIs

What is Doravirine?

Doravirine, an antiviral drug, prevents the human immunodeficiency virus (HIV) from multiplying within your body. Doravirine, along with other medications, is used to treat HIV. This virus can cause acquired immune deficiency syndrome. Doravirine does not cure HIV or AIDS. Doravirine can be used in other ways not mentioned in this guide.

Side effects of Doravirine

If you experience any of the following symptoms of an allergic reaction, seek immediate medical attention: hives, difficulty breathing, swelling of your lips, face, tongue, or throat.

Doravirine can affect your immune system and cause side effects. This may occur weeks or even months after taking doravirine. Inform your doctor if:

  • Signs of a new infection include fever, sweating at night, swelling glands, cold sores, coughing, wheezing, diarrhea, and weight loss.
  • Problems with balance, eye movements, or speech, or even a prickly sensation;
  • Impotence, menstrual changes, swelling of the neck or throat (enlarged thyroid)

Some of the common side effects associated with doravirine include:

  • Nausea, diarrhea, and stomach pain;
  • Headache, dizziness;
  • Tiredness;
  • Strange dreams.

There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.

Warnings

Inform your doctor of all the medications you are taking, as well as any new ones. Some drugs are not to be taken together, and others can cause drug interactions.

Before you take this drug

If you have an allergy to doravirine, then it is best not to use this product. Many drugs can cause harmful interactions. Certain drugs shouldn't be taken with doravirine. If you've taken any of these medicines within the last 4 weeks, your doctor may alter your treatment plan.

  • Enzalutamide;
  • Mitotane;
  • Rifampin;
  • Rifapentine;
  • John's wort;
  • Seizure medicine—carbamazepine, phenobarbital, phenytoin, or oxcarbazepine.

Use your medication properly to control infections. HIV can be transmitted to your child if you do not control the virus during pregnancy. You may have your name listed in a registry that tracks the effects of antiviral medicines on the baby. Breastfeeding is not recommended for women with HIV/AIDS. Even if the baby was born HIV-free, the virus can be transmitted to the infant through your breast milk. Doravirine should not be used by anyone under the age of 18.

How to take Doravirine?

Read and adhere to all instructions or guides included with your medication, as well as those stated on its label. Take your medicine every day at the same time, with or without eating. Doravirine can be taken only once per day. You may have to take doravirine twice a day if you are also taking a medicine named rifabutin. Do not forget to follow your doctor's instructions. Read all the instructions and medication guides that you receive. Do not alter your dosage or schedule without first consulting with your physician.Each person living with HIV should be under the care and supervision of a physician. Store the tablets away from heat and moisture at room temperature. Keep tablets in their original containers, with packets or canisters of moisture-absorbing preserver. Do not place the tablets in a daily pillbox.

Details on dosage

Adult dose for HIV infection:
Take 100 mg once daily.
Use: Antiretrovirals should be combined for effective HIV-1 infection therapy in those without prior history of antiretroviral treatment, or those already on stable regimens (HIV-1 RNA less than 50 copies/mL and without known resistant variants), who do not show evidence of treatment failure and no mutations associated with resistance against this agent.
The usual pediatric dose for HIV infection is:
If you weigh at least 35 kg, take 100 mg once daily.
Use: Antiretrovirals should be combined for effective HIV-1 infection therapy in those without prior history of antiretroviral treatment, or those already on stable regimens (HIV-1 RNA less than 50 copies/mL and without known resistant variants), who do not show evidence of treatment failure and no mutations associated with resistance against this agent.

What happens if I miss the dose?

If it is close to time for your next dose, skip any missed ones altogether and never take two doses at the same time. Refill your prescription before you run out. If you skip doses, your virus may become resistant to the medication.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

What should be avoided?

If your doctor prescribes any restrictions regarding food, beverage, or activity, follow their instructions.

Interaction with other drug

Tell your doctor if you are taking any other medications, including:

  • If you've taken rifabutin in the last 4 weeks, or if it was prescribed to you before that time,

This list is incomplete. Doravirine may be affected by other drugs, such as prescription and over-the-counter medicines, vitamins, and herbal products. This list does not include all possible drug interactions.

DRUG STATUS

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Prescription only

Pregnancy & Lactation

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