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Chlophedianol, dexchlorpheniramine, and pseudoephedrine

Generic names: chlophedianol, dexchlorpheniramine, and pseudoephedrine [KLOE-fe-DYE-a-nol, DEX-klor-fen-IR-a-meen, SOO-doe-ee-FED-rin].
Brand names: Panatuss PED, Vanacof, Panatuss PED Drops
Dosage form: oral liquid (12.5 mg-1 mg-30 mg/5 ml; 25 mg-2 mg-60 mg/5 ml; 6.25 mg-0.5 mg-15 mg/ml)
Drug Class: Upper Respiratory Combinations

What is Chlophedianol, dexchlorpheniramine, and pseudoephedrine?

Chlophedianol suppresses coughing. It works by affecting the signals that are sent to the brain and triggering the cough reflex.Dexchlorpheniramine helps mitigate the adverse reactions histamine has on your body. Histamine can cause symptoms such as sneezing and itching. It may also cause watery eyes and a runny or irritated nose.Pseudoephedrine works to clear congested nasal passageways by contracting blood vessels. Dilated blood vessels can cause congestion in the nasal passages.Combination medicine containing clophedianol dexchlorpheniramine and pseudoephedrine can be used to treat symptoms such as runny noses, sneezings, itching, watery eyes, cough, and sinus congestion due to allergies, flu, or the common cold.Chlophedianol, dexchlorpheniramine, and pseudoephedrine do not treat coughs caused by asthma, bronchitis, or emphysema.This medication guide does not list all possible uses of chlophedianol, dexchlorpheniramine, and pseudoephedrine.

Side effects of Chlophedianol, dexchlorpheniramine, and pseudoephedrine

If you experience any of the following signs and symptoms of an allergic reaction: difficulty breathing, hives or swelling to face lips throat

This medicine can cause serious side effects. If you experience:

  • Severe drowsiness;
  • A feeling of lightheadedness, as if you could pass out.
  • Severe dizziness or anxiety;
  • Severe restlessness or inability to sleep.

Side effects of dexchlorpheniramine and pseudoephedrine include:

  • Mild dizziness, drowsiness, or mild vertigo
  • Dry mouth, nose, or throat
  • Diarrhoea, constipation, upset stomach;
  • Feeling restless or excited, especially in children
  • Blurred vision
  • Sleep problems (insomnia).

There may be other side effects. Call your physician if experiencing side effects; to report adverse events call the FDA directly on 1-800-FDA-1088.


You should not take this medication if you've taken an MAO inhibitor in the last 14 days. Harmful drug interactions may occur. MAO inhibitors are isocarboxazid linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, Tranylcypromine, and others.

Before you take this drug

If you've used an MAO inhibitor in the last 14 days, do not take this medication. It is possible that a dangerous drug interaction will occur. MAO inhibitors are isocarboxazid (linezolid), phenelzine (phenelzine injection), rasagiline (selegiline), tranylcypromine, and other drugs.This medicine should not be used if you have an allergy to dexchlorpheniramine or pseudoephedrine.

If you have any other medical conditions or concerns, ask your doctor or pharmacist whether it's safe to take the medicine.

  • Any type of breathing disorder
  • Cough with mucus
  • Glaucoma
  • Diabetes;
  • Liver or kidney disease
  • High blood
  • A thyroid disorder,
  • If you are taking potassium (Cytra Epiklor K-Lyte K-Phos Kaon Klor-Con Polycitra Urocit-K),

Unknown is whether chlophedianol, dexchlorpheniramine, and pseudoephedrine can harm an unborn child. If you are pregnant, do not take this medication without consulting your doctor.Chlophedianol and dexchlorpheniramine can pass through breast milk, causing harm to a nursing infant. Decongestants and antihistamines can also reduce breast milk production. If you are breastfeeding a child, do not take this medication without consulting your doctor.

How to take Chlophedianol, dexchlorpheniramine, and pseudoephedrine?

Do not exceed the recommended dosage or duration. Use the recommended dose or duration. Do not exceed it. Cold or cough medicine is typically taken for only a few days until symptoms disappear.This medication should not be given to children younger than four years of age. Ask a doctor first before giving cough or cold medication to your child. Children as young as 4 years old can die from the misuse of cough medicines.Use a medicine cup or spoon to measure liquid medicines. Ask your pharmacist if you don't have a device for measuring doses.If your symptoms don't improve within 7 days or you experience a headache with a fever, cough, or skin rash, call your doctor.Tell your doctor or surgeon if you've taken cough medicine or cold medication in the last few days.Store away from moisture or heat at room temperature. Store at room temperature, away from moisture and heat.

Details on dosage

Adult dose for nasal congestion and cough:

Chlophedianol/dexchlorpheniramine/PSE 12.5 mg-1 mg-30 mg/5 ml oral liquid:
No more than 40 ml per day.The usual paediatric dose for nasal congestion and cough:Chlophedianol/dexchlorpheniramine/PSE 12.5 mg-1 mg-30 mg/5 ml oral liquid:
From 6 to 11: 5 ml every 6 to 8 hours, but not more than 20 ml per day.
For 12 years and older: 10 ml orally every six to eight hours, not exceeding 40 ml per day.

What happens if I miss the dose?

You may not have a schedule for taking cough and cold medicines. If you have a regular schedule, take the missed dose immediately after you remember. If your next scheduled dosage is approaching, skip the missed dose. You should not take extra medicine to compensate for a missed dose.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

What should be avoided?

This medicine can cause blurred or impaired vision or affect your thinking or reaction. You should be careful when driving or doing anything else that requires alertness and the ability to see clearly.Before using any other cold or allergy medicine or cough or sleep medication, consult your doctor or pharmacist. Many combination medicines contain antihistamines, antitussives, and decongestants. Combining certain products can lead to an overdose of certain drugs. You can check the label of a medication to see if it contains antihistamines, antitussives, or decongestants.Alcohol can enhance certain side effects from chlophedianol, dexchlorpheniramine, and pseudoephedrine.

Interaction with other drug

Before using this medication, ask your doctor or pharmacist if you also use any other medications, such as prescription and over-the-counter medicines, vitamins, and herbal products. When used together, some medicines can have unwanted or harmful effects. This medication guide does not list all possible interactions.This medicine can have a worsening effect if taken with drugs that cause you to sleep or slow down your breathing. Before taking chlophedianol, dexchlorpheniramine, and pseudoephedrine, consult your doctor if you are also taking sleeping pills, narcotics, muscle relaxers, anxiety, depression, or seizure medicine.