Cabometyx

What is Cabometyx?

Cabometyx, also known as kinase inhibitors or enzyme inhibitors, is an inhibitor of the activity of certain protein kinases. Cabometyx can be used in conjunction with nivolumab to treat advanced renal cancer. Cabometyx can be used to treat hepatocellular cancer in patients who have previously been treated with Sorafenib. Cabometyx can also be used to treat a type of thyroid carcinoma known as differentiated thyroid tumour (DTC), which has spread and progressed following treatment with VEGFR-targeted therapy. You are no longer able to take radioactive iodine, or it is not an option for you.

Warnings

Cabometyx can cause a perforation or fistula in your stomach or intestines. This medication can also increase the risk of severe bleeding. Contact your doctor immediately if you experience severe stomach pain or nausea, bleeding, bloody stools, or bloody tarry stools. You experience heavy menstrual blood flow.

Before you take this drug

Tell your doctor about any of the following to ensure Cabometyx will be safe for you:

• Low calcium levels in the blood (hypocalcemia);
• An open wound (or one that is healing) on the skin;
• Bloody or tarry stool, bloody vomit, or bloody coughing
• High blood pressure
• Liver disease
• A pre-existing dental problem.

Before starting the treatment, you may need to take a pregnancy test. Cabozantinib can harm an unborn child. Prevent pregnancy by using effective birth control while taking Cabometyx and for 4 months following your last dose. Inform your doctor immediately if you suspect you are pregnant.m Cabozantinib can affect both men and women's fertility (ability to have children). Cabometyx may harm an unborn child, so it's important to use birth control to avoid pregnancy. Cabometyx should not be used while breastfeeding or for at least four months after the last dose.

Similar/related drugs

Keytruda, Avastin, Armour Thyroid, Pembrolizumab, Nivolumab, Bevacizumab, and Doxorubicin

 How to take Cabometyx?

Follow the instructions on your prescription label and read all medication guides or instruction sheets. Read all the instructions and directions that come with your prescription. Sometimes your doctor will change the dose. Cometriq capsules (cabozantinib), not Cabometyx tablets, should be used instead. Only take the pills that your doctor prescribed. Always check the medication you receive from the pharmacy to avoid any mistakes. Take Cabometyx with an empty stomach at least one hour before eating or two hours after. Cabometyx should not be taken with food. Take this medication with a glass of water. You should not break, crush, or chew a tablet. Do not open the capsule. Swallow the entire pill. Nivolumab, when used in conjunction with Cabometyx, is typically given by vein injection every 2 to 4 weeks. You may need to check your thyroid and liver functions, as well as your blood pressure. Stop taking Cabometyx 3 weeks before you have surgery or dental work. You may have to wait up to 2 weeks after a dental or surgical procedure before you can take Cabometyx. Do not forget to follow your doctor's instructions. Talk to your doctor if you've stopped taking Cabometyx. Store away from heat and moisture at room temperature.

Details on dosage

Adult dose for renal cell carcinoma:

Tablets:
As a single agent, 60 mg once daily orally until the patient does not experience clinical benefit any longer or unacceptable toxicities occur
As a combination with Nivolumab, 40 mg per day for as long as the disease progresses or there is unacceptable toxicity
Refer to the prescribing information for nivolumab when administering this medication in combination with it.
Uses:
For patients with advanced renal cell carcinoma
In combination, nivolumab is indicated as the first-line treatment for patients with advanced RCC. Adult dose for hepatocellular carcinoma: Tablets: 60mg orally, once daily, until the patient does not experience clinical benefit any longer or unacceptable toxicities occur.
Patients with hepatocellular cancer (HCC) who have previously received sorafenib treatment Adult and paediatric doses for thyroid cancer As a single agent, the recommended dose for adults and children 12 years and older who have BSA of greater than or equal to 1.2 m2 is at least 60 mg daily until disease progression occurs or there are unacceptable side effects. As a single agent, the recommended dose for paediatric patients aged 12 and older who have a BSA of less than .2 m2 iis a daily dose of 40 mg until disease progression occurs or unacceptable toxicities occur. Use: metastatic or locally advanced differentiated thyroid carcinoma (DTC), who have progressed after prior VEGFR-targeted treatment and are ineligible for radioactive iodine.

What happens if I miss the dose?

If you miss a dose, take it as soon as possible. Skip the missed dose when your next dose is less than 12 hours away. Never take two doses of the same medicine at once.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

What should be avoided?

Grapefruit can cause unwanted side effects when taken with Cabometyx. Use grapefruit products sparingly while taking cabozantinib. St. John's wort is a dangerous herb. John's wort.

Side effects of Cabometyx

If you experience any of the following symptoms of an allergic reaction: hives, difficulty breathing, swelling of your lips, face, tongue, or throat, contact emergency medical assistance. Cabometyx can cause a fistula or perforation in your stomach or intestines. If you experience severe stomach pain or feel as if your throat is closing up, call your doctor.

If you experience:

• Severe headache; blurred vision; or pounding in the neck and ears
• Severe and persistent symptoms of nausea or diarrhea;
• You may experience swelling of your hands, feet, arms, or legs.
• Easy bruising and bleeding (nosebleeds, bleeding gums, heavy menstrual bleeding, or any bleeding that will not stop);
• Bloody or tarry stools; a cough that produces bloody mucus; or vomit that looks like coffee grounds
• Jaundice
• Pain, blisters, bleeding, or severe rash on the soles or palms of the feet or hands
• Confusion, weakness, confusion, seizures, and thinking problems
• Feeling dizzy as though they could faint.
• After dental work, you may experience jaw pain, numbness, or red gums. You might also notice loose teeth or slow healing.
• Low blood calcium, muscle contractions, numbness, or tingling in the fingers or toes
• Low counts of white blood cells; fever; sores on the lips; sores on the skin; sores in the throat; coughing; difficulty breathing.
• Adrenal problems: nausea, vomiting, extreme fatigue, dizziness, weakness, fainting, or
• Signs of a stroke include sudden numbness, weakness, or difficulty speaking or understanding what you are being told, chest pain, breathing difficulties, or swelling in your arm or leg.

If you experience certain side effects, your future cabozantinib doses may be permanently delayed or discontinued.

Cabometyx may cause side effects such as:

• Tiredness, depression, dry skin, hair thinning, weight gain, and puffiness of the face
• Constipation, diarrhea, nausea, stomach pain, and vomiting
• Pain, swelling, or sores on your tongue or throat
• Trouble speaking is a change in taste.
• Cold symptoms like stuffy noses, sneezings, sore throats, and coughs
• Rash;
• Pain in your joints, muscles, or bones;
• Abnormal liver function tests and other blood tests
• Weight loss;
• Hair colour is changing to lighter.

There may be other side effects. For medical advice on side effects, call your doctor.Contacting the FDA with side-effect complaints is easy: call them on 1800FDA-1088!

Interaction with other drug

It is sometimes not safe to take certain medications together. Taking certain drugs together can cause side effects and/or make other medications less effective. Other drugs, such as vitamins and herbal remedies, may also interact with cabozantinib. Informing your physician of all medications you are currently taking and those which you begin or stop taking is also recommended.