The Web Health



Generically Name is: [KOM-ple-ment-C1 ES-ter-ase-in-HIB-it-or] Complement C1 esterase inhibitor.
The Class of Drug: Hereditary angioedema agents.

What is Berinert?

Berinert is a man-made version of a protein that is found naturally in blood streams and assists in reducing swelling in the body. People suffering from angioedema due to genetics don't have adequate amounts of this particular protein. An inherited angioedema can lead to manifestations of swelling, like stomach pain or breathing problems. Berinert is prescribed to patients who have hereditary angioedema.

Berinert is a treatment for angioedema attacks. There are two brands: Cinryze and Haegarda. Brands are employed to stop attacks of angioedema.


It is not recommended to use Berinert if you've ever experienced an allergy that could be life-threatening. the complement C1 estrase inhibitor. Before receiving Berinert, consult your physician to determine whether you have an antecedent history of blood clots or stroke.

Take a break from the Berinert infusion immediately and seek urgent medical attention if you experience any of the following warning signs of an allergic reaction: wheezing, hives, or difficulty breathing; feeling as if you're going to pass out; as well as swelling or redness of the lips, face, and tongue. Other serious side effects can include sudden weakness or numbness, as well as chest pain, confusion, swelling, or pain, and difficulties with speech, vision, or balance.

Berinert is derived from consuming the blood plasma of humans (a part that is part of the blood) that could contain infections and viruses. Plasma donated to the clinic is tested and treated to decrease the possibility of it containing infectious agents; however, there is still a chance of it transmitting diseases. Consult your doctor about the dangers and benefits of this treatment.

Before you take this drug

It is not recommended to take Berinert. If you've ever experienced an allergy that could be life-threatening, the C1 esterase inhibitor of complement. Discuss with your physician if you have ever diagnosed:

  • A blood clot or stroke.
  • Heart conditions.
  • An "in-dwelling" catheter.

Inform your doctor if you are nursing or pregnant. Berinert is derived from donated human plasma and could contain viruses and different infectious agents. Plasma donated to the lab is tested and treated to lower the chance of contamination, but there's a possibility that it may carry the disease. Consult with your physician about any potential risks.

How to take Berinert?

Utilize Berinert exactly as directed by your physician. Follow the instructions on the label of your medicine prescription. Do not take this medicine in smaller or larger quantities or for longer periods than the recommended time. Berinert is injected into a vein via an IV. You might be taught how to administer injections at home. Don't inject yourself with this medication if you do not know how to apply the injection properly and eliminate the injection tubing, needles, and other equipment used.

Check all the information about your patient, including medication guides and instruction sheets that you receive. Talk to your pharmacist or doctor about any additional concerns. Berinert is a medication in the form of a powder that needs to be mixed with liquid (diluent) prior to use. Follow the directions with care. Make sure you know how to prepare and keep the medication. Swirl gently, but don't shake the mixture; otherwise, you risk ruining the mix. Make sure to prepare your dose once you are ready to inject yourself. The diluent and powder mixture should be transparent and non-colored. Don't use the mixed medicine if it has changed color or contains particles. Consult your pharmacist about the latest medication.

Every single-use bottle that contains this medication is intended for use once only. It is discarded after one use, regardless of whether there is any remaining medicine inside. Berinert contains no preservatives. After you've punctured the top of the rubber vial using a needle, you should use the vial as soon as possible or dispose of it.  Keep the dry powder unmixed in a refrigerator at cool temperatures. Keep away from lights and avoid freezing. Recycle any vial that is not used after its time limit on the label has passed. When you have mixed the Berinert and the diluting, use it immediately or keep the mixture at room temperature and use it within 8 hours. Utilize an empty needle and syringe just once. Be sure to follow any local or state laws regarding disposing of needles and syringes that are no longer in use. Make sure you use a puncture-proof "sharps" disposal container (ask your pharmacist for one and what to do with the container). Keep the container away from pets and children.

Details on dosage

Usual Adult Dose for Hereditary Angioedema:

To treat acute laryngeal, facial, or abdominal symptoms of HAE
Berinert delivers 20 units per kilogram of bodyweight intravenously for around 4 milliliters per minute (500 units per 10 mL).

Usual Pediatric Dose for Hereditary Angioedema:

To treat acute abdominal, laryngeal, or facial HAE attacks:
Ages 13 and over: Berinert 20 units per kg of body mass intravenously, at an amount of around 4 mL/min (500 units per mL).

What happens if I miss a dose?

Contact your doctor for advice when you have missed a dose.

What happens if I overdose?

Get medical attention in an emergency or contact the Poison Help line toll-free at 1-800-222-1222.

What should be avoided?

Follow the doctor's advice regarding any restrictions on your food, drink, or activities.

Side effects of Berinert

Take immediate medical assistance. If you notice indications that you are experiencing an allergic reaction, Berinert: hives, chest tightness, rapid heartbeats, feeling lightheaded, and wheezing, You may also experience difficulty breathing, blue gums or lips, as well as swelling or tightness of the lips, tongue, throat, or face.

See your doctor right away. If you are suffering from:

  • The sensation of numbness or weakness suddenly on either side.
  • The sensation of pain, swelling, or redness in the leg or arm.
  • A sudden and extreme headache or confusion, issues with speech, vision, or balance.
  • Chest pain after breathing deeply.
  • Rapid heart rate.

Common Berinert adverse effects:

  • Unusual or unpleasant taste in your mouth.
  • Headache, dizziness.
  • Nausea, vomiting.
  • Discomfort, bruising, itching, bleeding, swelling, the sensation of warmth, or a lump in the area where the medication was injected.
  • Nasal stuffiness, sore throat.
  • It can be a rash.
  • Fever.

This isn't a complete list of all the side effects. Others could happen. Contact your doctor for medical advice on the consequences. You can report any adverse reactions to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Discuss with your doctor all other medicines you take, including:

This list is not comprehensive. Other medications may interfere with complement C1 esterase inhibitors, such as prescription and over-the-counter medications, vitamins, and herbal remedies. Some interactions with drugs are not listed here. are included here.



Prescription only

Pregnancy & Lactation

CSA Schedule*
Related Drugs
Related Stories