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Avibactam and cefTAZidime

Generic name: avibactam and ceftazidime [AV-i-BAK-tam-and-sef-TAZ-i-deem]
Brand name: Avycaz Dosage form: intravenous powder for injection (0.5 g–2 g)
Drug class: cephalosporins and beta-lactamase inhibitors

What are Avibactam and cefTAZidime?

The combination of ceftazidime and Avibactam is used for treating complicated stomach, kidney, and bladder infections in children and adults as young as three months.Only adults are treated with ceftazidime and avibactam for pneumonia that has occurred during or soon after an inpatient stay.This medication guide does not list all possible uses for ceftazidime and avibactam.

Side effects of Avibactam and cefTAZidime

If you experience any of the following symptoms of an allergy reaction, seek immediate medical attention: difficulty breathing, hives, swelling in your lips, face, throat, or tongue.

There are serious side effects associated with ceftazidime and avibactam. If you experience:

  • Severe abdominal pain, diarrhoea, watery or bleeding;
  • A seizure (convulsions);
  • Overactive reflexes, rigid muscles;
  • Confusion, hallucinations,
  • A change in mentality.

Some of the common side effects associated with avibactam or ceftazidime include:

  • Nausea, vomiting;
  • Diarrhoea;
  • There may be bruising at the site where the iv is inserted.

There may be other side effects. For medical advice on side effects, call your doctor. Report any adverse reactions by calling the FDA's 24-hour hotline: 1-800-FDA-1088.


Please read all the instructions on the label or package of your medication. Inform your doctors about your allergies and medical conditions. Inform them what medicines you are currently taking.

Before you take this drug

If you have an allergy to cephalosporins such as cefTAZidime or avibactam, then it is best to avoid using avibactam.

  • Cefaclor
  • Cefadroxil (Duricef);
  • Cefazolin (Ancef);
  • Cefdinir (Omnicef);
  • Cefditoren (Spectracef);
  • Cefprozil (Cefzil);
  • Ceftibuten (Cedax);
  • Cefuroxime (Ceftin);
  • Cephradine (Velosef);
  • Cephalexin; Keflex

If you've ever:

  • A stomach or intestinal disease such as colitis.
  • Kidney disease
  • An allergy to penicillin (including amoxicillin and ampicillin as well as Augmentin, diloxacillin, and oxacillin)

Inform your doctor of any pregnancy or breastfeeding.

How to take Avibactam and cefTAZidime?

Infusions of ceftazidime and avibactam are administered into the vein. Your healthcare provider may give you your first dose and teach you to use it properly.The infusion may take up to 2 hours. This medicine may be needed for as long as 14 days. Do not forget to follow your doctor's instructions.Please read and follow all instructions for use that come with your medication. If you don't understand the instructions, ask your pharmacist or doctor.In an IV bag, Avibactam or Ceftazidime should be mixed with liquid (diluent). If you are using the injections yourself, make sure that you know how to mix and store them.Store the IV bag in room-temperature storage after mixing and use within 12 hours.The IV bag can be stored in the refrigerator for up to 24 hours. Don't freeze. Once you remove the IV bag from the fridge, it must be used within 12 hours.If the ceftazidime or avibactam has changed colour, particles are present in it. For new medications, call your pharmacist. It should be clear or light yellow.Even if you feel better quickly, continue to take this medication for as long as prescribed. You can get infections resistant to medications if you skip doses. Ceftazidime and Avibactam will not work on a virus, such as the flu.If your symptoms don't improve or worsen, call your doctor.It can interfere with certain tests. Inform any physician who treats you about your use of avibactam or ceftazidime.Keep avibactam and ceftazidime unmixed at room temperature, away from heat and moisture. The vials (bottles) are only for one-time use. After one use, throw it out, even if the medicine is still inside.Only use a needle or syringe once, and place it in the "sharps container" to prevent punctures. Be sure to follow local or state laws on how you should dispose of the container.Keep it out of reach from both pets and children.

What happens if I miss the dose?

If you missed a dose, call your doctor to get instructions.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

Avoid this

It is possible that antibiotics can lead to diarrhea. This could be an indication of a fresh infection. Call your doctor if you experience diarrhoea that's watery or bleeding.

Interaction with other drug

Other medications, such as vitamins and herbal remedies, may also affect ceftazidime and avibactam. Inform your doctor of all the medicines you are currently taking and those that you will begin or stop using.