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Asparaginase Erwinia chrysanthemi

Generic name: asparaginase Erwinia chrysanthemi [as-PAR-a-jin-ase-er-WIN-ee-a-kri-SAN-the-mee]
Brand names: Erwinase, Rylaze, Erwinaze
Dosage forms: injectable powder for injection (10000 units); intramuscular solution containing 10 mg/0.5 mL of Rywn Recombinant DNA, both administered intramuscularly.
The class of drug: miscellaneous antineoplastics

What is Asparaginase Erwinia chrysanthemi?

Asparaginase Erwinia Chrysanthemi is one of the cancer treatments.Erwinase is used to treat acute lymphoblastic leukemia in children and adults aged at least 4 years old who are now allergic to different forms of asparaginase like Elspar, Oncaspar, or Rylaze.Rylaze can be used to treat the acute form of lymphoblastic leukemia and lymphoblastic lymphoma in adults and children with a minimum age of 1 month who are allergic to different forms of asparaginase, such as Elspar, Oncaspar, or Erwinase.Asparaginase Erwinia Chrysanthemi can also be used for reasons not mentioned in this guideline.

Side effects of Asparaginase Erwinia chrysanthemi

Contact a medical professional immediately. Get medical attention immediately if you notice symptoms that indicate an allergic reaction, like hives, trouble breathing, or swelling of your lips, face, and tongue.

Asparaginase Erwinia Chrysanthemi could cause serious adverse side effects. Consult your physician right away if you experience:
bleeding or bruising (nosebleeds or bleeding gums);

  • Any bleeding that doesn't stop;
  • The appearance of blisters or ulcers inside your mouth; swollen or red gums; difficulty swallowing;
  • Symptoms of pancreas or liver problems: stomach pain that is severe (that can extend to your lower back); nausea or vomiting; jaundice (yellowing of the eyes or skin);
  • Symptoms of a blood clot: sudden feeling of weakness or numbness (especially in one part of your body) and extreme headache and chest pain; feeling tired; swelling or pain in the leg or arm;
  • Low white blood cell count low white blood cell counts low white blood cell counts, or mouth sores, open sores in the skin, a sore throat, cough,
  • High blood sugar—increased thirst, more frequent urinary frequency, dry mouth, and a fruity breath smell

Your treatment for cancer could be delayed or completely stopped when you experience certain negative side effects.

Common adverse results of asparaginase erwinia chrysanthemi can be:

  • Pancreas and liver problems;
  • The bleeding of blood or blood clots
  • High blood sugar
  • Stomach nausea, pain in the stomach, nausea, vomiting, nausea, diarrhea;
  • Fatigue, headache, fever, and mouth sores.
  • Muscle and joint discomfort;
  • Allergic reaction, skin rash,
  • Atypical liver test results

This list may not provide all possible side effects of Azelex(r). Others could happen. Contact your doctor for advice regarding medical adverse effects. You may report any adverse reactions to the FDA at 1-800-FDA-1088.


Only use it according to the directions. Inform your doctor if you are taking other medications or have any medical conditions or allergies.

Before you take this drug

It is not recommended to make use of asparaginase. Erwinia Chrysanthemi if you've received any form of asparaginase previously that caused you to develop:

  • An allergic reaction that is serious;
  • Serious pancreas problems;
  • A life-threatening blood clot;
  • Serious bleeding problems.

Speak to your doctor if you were ever diagnosed with:

  • Issues with your liver or pancreas;
  • Bleeding issues;
  • A blood clot,
  • Diabetes.

could harm a baby born. You may need an ultrasound test to be sure you're not pregnant. Make sure you use contraceptives when you are taking this medication and at least three months after the last dose. Consult your physician when you fall pregnant.Asparaginase Erwinia chrosanthemi may make hormonal contraceptives less efficacious, which includes contraceptive injectable implants, skin patches, and vaginal rings. Utilize birth control barriers to prevent pregnancy: condoms, diaphragm cervical caps, condoms, and contraceptive sponges.Don't breastfeed while taking this medication, and at least 3 months after the final dose of Erwinase or one week following the final dose of Rylaze,

How to take Asparaginase Erwinia chrysanthemi?

Follow all instructions listed on your prescription label and review any medication guides or instruction sheets provided with medication.Follow the medication exactly as prescribed.Asparaginase Erwinia chrysanthemi can be injected into muscles or the vein. Erwinase is typically administered each day for 48 hours. Rylaze may be administered every 48 hours, or three times per week.Follow and read carefully any instructions for use that are included in the medication. Consult your physician or pharmacist to help you understand the procedure for using an injection.Your physician will inform you of the best place to inject asparaginase, Erwinia Chrysanthemi. Do not inject the same area twice in the same row.Do not shake the medicine bottle, or you could ruin the medicine.Only inject when you are prepared to administer it. Contact your pharmacist if the medicine is changing colors or contains particles.Don't reuse needles or syringes. Put them in an impervious-to-punch "sharps" container and dispose of them according to local or state laws. Keep it out of reach from animals and children.Your blood needs to be checked frequently, and your dosage or schedule of medication could be altered based on the results.Doses are determined by the body's surface (height as well as weight). The dose you take could change when you lose or gain weight, or if you are still expanding.There are additional medications to help you avoid severe side effects or allergic reactions. Continue taking these medications for the duration your physician prescribes.Toss out the bottle after a single use, regardless of whether there is medicine in it.Be sure to follow all storage instructions given with asparaginase Erwinia Chrysanthemi. Your pharmacist can give you more details about storage methods for this medication.

What happens if I miss the dose?

Contact your doctor for advice when you have missed the dose.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact for help at the Poison Help Line at 1-800-222-1222.

What should be avoided?

Follow the instructions of your physician regarding any restrictions on your food, drink, or activities.

Interaction with other drug

Other medications can cause asparaginase to be affected. Erwinia Chrysanthemi. This includes medications that are Over-the-counter vitamins and herbal products may also be prescribed.Discuss with your doctor all the other medicines you take.