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Genric Name: argatroban ar-GAT roe-ban [ar-GAT-roe-ban]
Name of the brand: Acova
Dosage format: intravenous solution (1 mg/mL, 100 mg/mL)
Drug class: Thrombin inhibitors

What is Argatroban?

Argatroban inhibits the action of certain substances that clot the blood.Argatroban is a medication used for treating or preventing blood clots in people who suffer from the condition of thrombocytopenia (low amounts of platelets in blood) due to the use of the drug heparin. Argatroban is often prescribed to patients undergoing an operation known as angioplasty (to unblock blocked blood vessels).Argatroban can also be used to treat conditions not mentioned in this guideline.

Side effects of Argatroban

Contact a medical professional immediately in the event that you exhibit symptoms or warning signs of an allergic reaction, such as asthma, hives, and swelling of your lips, face, or tongue.

Argatroban may cause serious side effects. Should symptoms present themselves immediately after applying first aid measures such as:

  • Bleeding or bruising (nosebleeds, bleeding gums, large menstrual blood);
  • Sudden swelling or pain;
  • Any bleeding that does not stop;
  • A feeling of lightheadedness, as if you're about to pass out.
  • The stool is bloody, tarry, and coughing blood; or it is vomit that resembles coffee grounds.
  • Urine that appears pink, red, or brown;
  • Low heart rate slow heart rate, weak pulse, fainting, or sluggish breathing (breathing may cease);
  • Symptoms or signs of symptoms of infection include fever, flu symptoms, throat and mouth ulcers. Rapid heart rate and breath that is shallow.

Common adverse effects of argatroban could include:

  • Infection;
  • Issues with heart function
  • Fever;
  • Nausea, vomiting, diarrhoea;
  • Lower blood pressure;
  • Breathlessness;
  • Headache, back pain,
  • Chest pain.

This isn't an exhaustive list of possible side effects, and other side effects could occur. Consult your physician to seek medical advice on adverse effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.


Argatroban is not recommended in the event of major bleeding due to an operation, injury, or any other cause.Argatroban may be able to stop bleeding even from minor injuries. Seek medical attention when you notice unusual bruises or bleeding that does not stop.

Before you take this drug

It is not recommended to take argatroban when you have an allergy to it or if you suffer from any significant bleeding as a result of a procedure, injury, or another reason.

Speak to your doctor if you have ever suffered from:

  • A stomach ulcer or bleeding
  • The liver condition;
  • A blood clotting or bleeding condition (such as haemophilia);
  • Uncontrolled or severe excessive or uncontrolled;
  • A spinal tap, epidural anaesthesia,
  • Major surgical procedure, especially major surgery (especially eye surgery, brain surgery, and spinal cord surgeries).

Argatroban used in late pregnancy can cause bleeding to the mother or baby during birth. Tell your doctor when you're pregnant and taking argatroban.As with most medications, breastfeeding while on this medication should not be done.Consult your physician about any potential risks.Argatroban is not permitted for use by anyone who is younger than

How to take Argatroban?

Argatroban is administered as an injection into the vein. The healthcare professional will give you the injection.Argatroban is administered to ensure that your blood is coagulated. Your doctor will examine your blood regularly to determine the length of time to administer argatroban.Argatroban could cause bleeding even after a minor injury. Seek medical attention when you notice unusual bruises or bleeding that will not stop.

What happens if I miss the dose?

Because argatroban is administered by a health specialist, you're not likely to skip a dose.

What happens if I overdose?

Because argatroban is prescribed by a medical specialist, when it is administered by a healthcare professional in a medical setting, it is highly unlikely for an overdose to occur.

What should be avoided?

Avoid activities that could increase the chances of sustaining injuries or bleeding. Make sure you take extra precautions to prevent bleeding during shaving or brushing your teeth.Avoid alcohol. It could increase the chances of bleeding in the stomach or intestines.

Interaction with other drug

Discuss with your doctor the other medications you are taking and other medications, particularly those that prevent or treat blood clots.Other medications can affect argatroban, which includes medications that are prescribed and available over the counter, vitamins, and herbal products. Discuss with your doctor all the medicines you are currently taking, as well as any medicines you take or stop taking.