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Generic name: acetaminophen and benzhydrocodone [a-SEET-a-MIN-oh-fen-and-BENZ-hye-dro-KOE-done]
Drug class: narcotic analgesic combinations

What is Apadaz?

Apadaz is a mixture of acetaminophen and benzhydrocodone. Benzhydrocodone can be described as an opioid painkiller. The opioid medication is sometimes known as "narcotic.Acetaminophen is a weaker pain reliever, which increases the effects of benzhydrocodone.Apadaz is a prescription-only pain medicine that is used for quick-term relief of mild to extreme pain.Apadaz could be a habit-forming drug.

Details on dosage

A high dose of Apadaz could damage the liver or result in the death of a person. Call your doctor immediately if you experience abdominal pain or a loss of appetite. dark urine as well as jaundice (yellowing of your eyes or skin).The misuse of opioids could lead to addiction, overdose, or even death. Keep the medication at a distance from where others are unable to access it.Opioid medicine taken during pregnancy could trigger withdrawal symptoms that could be life-threatening for the infant.Side effects that are fatal can be experienced if you take opioid medication in combination with alcohol or other medications that cause drowsiness or impede the rate of breathing.Do not take Apadaz, and contact your doctor immediately if you notice the appearance of a rash or redness on your skin that spreads and causes blistering as well as peeling.

Before you take this drug

It is not recommended to use Apadaz in the event that you are allergic to acetaminophen or hydrocodone or suffer from:

  • Serious, severe asthma, breathing issues,
  • Obstruction in your stomach or your intestines.

To be sure apadaz is safe for you, ask your physician if you've previously had:

  • Breathing difficulties; sleep apnea (breathing ceases during sleep);
  • Liver disease;
  • An addiction to alcohol or drugs;
  • Kidney disease;
  • A head injury or seizures;
  • Problems with urination and
  • Issues that concern your pancreas, thyroid, or gallbladder.

If you are taking opioids while pregnant, your child could develop dependence on the medication. This can cause withdrawal symptoms that can be life-threatening for the newborn after it's born. Babies born dependent on opioids may need medical treatment for several weeks.Consult a physician before taking Apadaz if you are nursing. Tell your doctor in case you notice a sudden increase in sleepiness or a slow breathing rate during the breastfeeding baby's

How to take Apadaz?

Use Apadaz exactly as directed by your physician. Follow the instructions on your prescription label and go through all the medication guides. Don't use this medicine in large quantities or for more than 14 consecutive days. An accidental overdose may damage or even result in death. Consult your physician if you notice an increase in your desire to take more medication.Do not give away Apadaz to someone else or anyone with an addiction history. The misuse of Apadaz can cause addiction, overdose, or death. Store the medicine in a place where others are unable to access it. The act of selling or giving away Apadaz is illegal.If you are in need of an operation or medical test, inform your doctor in advance of the reason you're taking this medicine.Do not stop taking Apadaz abruptly. Follow your doctor's advice on increasing your dosage.Place it in a cool, dry place far from heat and moisture. Make a note of the medicine you have purchased. It is important to be aware if someone is taking it incorrectly or without a prescription.Do not store any of your leftover opioids. One dose could cause death if someone is using Apadaz in error or incorrectly. Ask your pharmacist for a disposal program. If there's no take-back service, dispose of the remaining medication down the toilet.

Details on dosage

Usual Adult Dose for Pain:

Therapy that is individualised, taking into consideration the intensity of pain, previous treatment with analgesics, as well as potential risk factors for addiction abuse and misuse
As First Opioid Analgesic:
Initial dose: one or two tablets (acetaminophen 325–650 mg/benzhydrocodone 6.12–12.24 mg) orally every 4–6 hours, as necessary to treat pain.
Titrate the dose until it gives adequate analgesia and minimises adverse reactions.
Maximum dose: 12 tablets/24 hours
Maximum acetaminophen dose (including all acetaminophen-containing products): 4000 mg in a 24-hour period
The duration of treatment The duration of therapy is 7 to 14 days.
Equivalence to Hydrocodone Bitartrate:
Benzhydrocodone, 4.08 mg, is equal to 5 mg.
Benzhydrocodone 6.12 mg, equivalent to bitartrate hydrocodone 7.5 mg
Benzhydrocodone (8.16 mg) is equivalent to 10 mg.
This medication is best reserved for patients who have other treatments (e.g. non-opioid analgesics) are not accepted, are not anticipated to be tolerated, do not provide adequate analgesia, or aren't considered to be able to provide adequate analgesia.
Utilise the lowest dose for the most short duration that is in line with the specific treatment goals of each patient.
Watch carefully to look out for breathing depression, particularly during the first 24–72 hours after starting treatment and after any increase in dosage.
As with all opioid medications or opioid derivatives, variability between patients can occur. If you are switching from other opioids to this particular drug, it is better to underestimate the requirements of the patient rather than overestimate doses and manage any adverse reactions resulting from an overdose.
Use: For short-term treatment of acute pain so severe as to require an opioid and for which other treatment options are not sufficient.

What happens if I miss the dose?

Because Apadaz is used to treat pain, it's unlikely to skip the dose. Do not take any dose missed when it's time to take the next dose. Do not take both doses at the same time.

What happens if I overdose?

Take immediate medical attention, contact medical attention immediately, or call the Poison Help Line at 1-800-222-1222. A dose of Apadaz can cause death, especially for children or any other person who is taking the drug without a prescription. Overdose symptoms may include nausea, vomiting, sweating, extreme sleepiness, aplenty of pupils that are sluggish, slow breathing, or the inability to breathe.A doctor may suggest getting Naloxone (a medication that reverses an overdose of opioids) and carrying it in your bag throughout the day. Someone who cares for you could administer Naloxone in the event that you lose your breath or don't get up. The carer should still seek medical assistance in an emergency and might need to administer CPR (cardiopulmonary resuscitation) to you as they wait for assistance to arrive.Naloxone can be purchased at pharmacies or your local health department.It is important that everyone who cares for you is aware of the location where you store your naloxone and how to make use of it.

What should be avoided?

Avoid operating machinery or driving until you are aware of how Apadaz can impact you. Dizziness or drowsiness could cause accidents, falls, or even serious injuries.

Avoid drinking alcohol. Dangerous side effects or even death could happen.

Consult a physician or pharmacist prior to using any other medication that could contain acetaminophen (sometimes known as APAP). When you take certain medications at the same time, it can result in a death-threatening overdose.

Side effects of Apadaz

Take immediate medical attention. If you show symptoms of an allergic reaction, Apadaz: hives, breathing difficulties, and swelling of your lips, face, and tongue.Opioid medicines can reduce or stop your breathing and even cause death. Anyone who cares for you should administer Naloxone or seek medical attention if there is prolonged breathing, pauses in your breathing, blue-coloured lips, or if it is difficult to get up.In rare instances, acetaminophen can cause a serious skin reaction that could cause death. This could occur even if you've taken acetaminophen before and did not experience any reaction. Do not take Apadaz, and consult your doctor immediately if you experience an itch or redness on your skin that becomes more severe and leads to blisters or peeling.

Contact your doctor immediately. If you suffer from:

  • Sighing, noisy breathing, deep breathing, sleeping that ceases;
  • A feeling of lightheadedness, as if you're passing out;
  • Liver issues nausea, stomach pain, fatigue, and lack of appetite black stools, dark urine, and jaundice (yellowing of the eyes or skin);
  • Low levels of cortisol—nausea, vomiting, loss of appetite, dizziness or nausea, and a worsening weakness or tiredness; or
  • Serotonin levels that are extremely high within the body, which causes hallucinations, agitation, and sweating. Rapid heart rate, shivering muscles, stiffness, twitching, loss of coordination, nausea, diarrhea, and  vomiting.

Risky side effects are more likely to occur in older patients and those who suffer from malnutrition or are debilitated.

The long-term use of opioids can alter fertility (the ability to have kids) for women or men. It isn't known if the effects of opioids on fertility are permanent.

Common Apadaz side effects include:

  • Dizziness, drowsiness, feeling tired;
  • Nausea, vomiting, and stomach pain;
  • Constipation
  • Headache.

This isn't an exhaustive list of possible side effects, and other side effects could occur. Contact your doctor for advice regarding medical adverse effects. Report any adverse side effects directly to the FDA by calling them at 1-800-FDA-1088.

Interaction with other drug

You might experience breathing issues or withdrawal symptoms when you take or stop using certain other medications. Talk to your doctor if you are also using medication, such as an antibiotic or antifungal medication. blood pressure or heart medications, seizures medication, or medication to treat HIV as well as Hepatitis C.

Opioid medicine can interact with various other medications and cause deadly side effects or even death. Be sure your doctor is aware if you take:

  • Medications for allergies or colds, such as the bronchodilator asthma or COPD medication or diuretic ("water pill");
  • Medicines to treat motion sickness and irritable bowel syndrome medicines for motion sickness, irritable bowel syndrome, and the overactive bladder;
  • Other opioids, such as opioid pain medicine and prescription medicine for cough
  • A sedative similar to Valium: diazepam, alprazolam, lorazepam, Xanax, Klonopin, Versed, and more
  • Drugs that can make you tired or cause breathing to slow, such as a sleep pill, a muscle relaxer, or medication to treat mental illness.
  • Serotonin-related drugs can alter the concentrations in the body. Stimulant, or a medicine for Parkinson's disease, depression, migraine headaches, serious illnesses, nausea, or vomiting.

This list isn't complete. Other medications may be incompatible with benzhydrocodone and acetaminophen, which include prescription and over-the-counter medications, vitamins, and herbal remedies. There are many possible interactions that are not included here.




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