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Generic Name: Crizanlizumab-tmca
Form of Dosage: Injection, for Intravenous use
Classification of Drugs: Miscellaneous Uncategorized Agents
Approval Date: November 15, 2019
Company: Novartis Pharmaceuticals Corporation

Active ingredient: Crizanlizumab-tmca
Ingredients That are Inactive: Citric acid, Polysorbate 80, Sodium citrate, and Water to inject

Patient Information

Check out this patient information prior to beginning treatment. This information should not be taken in place of talking with your healthcare professional regarding your medical condition or treatment.

What is Adakveo?

Adakveo is used to:

  • For people who are aged 16 and older and suffer from sickle cell disease.

  • To decrease the frequency of certain events (crises) to help reduce the frequency with which certain episodes (crises) occur.

It isn't known whether Adakveo is secure and effective for youngsters under 16 years old age.


Adakveo may cause serious side effects, including:
Reactions to infusion

. Infusion reactions can occur within the first 24 hours after getting an injection of Adakveo. Contact your healthcare professional immediately if you experience one of these signs or symptoms of an adverse reaction to an infusion:

  • Febrile

  • Chills or shaking

  • Nausea

  • Vomiting

  • Tiredness

  • Dizziness

  • Sweating

  • Hives

  • Itching

  • Wheezing or breath shortness.

Your doctor may be monitoring your health for symptoms and signs of an infusion reaction.

Inform your doctor that you're receiving Adakveo prior to having the blood test. Adakveo can affect a lab test to check your platelet counts.

Check out

Adakveo's side effects

for more details about the side effects.

Before You Take This Drug

Before receiving Adakveo, inform your doctor about your medical issues, including the following:

  • Are pregnant, planning to be pregnant, or plan to be pregnant. It's not clear whether Adakveo can affect your baby's development.

  • Are breastfeeding or planning to. It isn't known whether Adakveo is absorbed into milk. You and your healthcare professional must decide on the best method to feed your child while you are undergoing treatment.

Inform your doctor about every medicine you use and are taking, including prescription and over-the-counter supplements, vitamins, and herbal supplements.

How To Take Adakveo?

  • The healthcare professional will give you Adakveo, an infusion into your vein via the IV line that lasts for 30 minutes.

  • The first infusion and another infusion two weeks later Following that, you'll receive an infusion every four weeks.

  • Your doctor may recommend other medications for you to consider during treatment.

  • Don't stop taking this medication unless your doctor recommends it.

  • If you don't make an appointment to receive an infusion, contact your healthcare provider immediately to make a new appointment.

Side Effects Of Adakveo 

Adakveo may cause serious side effects.

The most frequent side effects are:

This is not the only list of possible adverse consequences. For more information, consult your doctor. Consult your doctor for advice from a medical professional regarding the effects of side effects. You can report any symptoms to the FDA at 1-800-FDA-1088.

Details on Dosage

Sometimes, medicines are used for reasons other than those mentioned in the patient information leaflet. It is better to ask your doctor or pharmacist for further information.