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Acyclovir and Hydrocortisone Topical

Generic Name: Acyclovir and Hydrocortisone Topical [a-SYE-kloe-vir-and-HYE-droe-KOR-ti-sone-TOP-ik-al] is the Generic Name.
Dosage Form:
Topical Cream (5%-1%)
Drug Class: Topical Steroids With Anti-infectives

What  are Acyclovir, Hydrocortisone, and Topical?

Acyclovir can be described as an antiviral drug. Hydrocortisone can be described as a drug called a steroid.Topical hydrocortisone and acyclovir (for the face) are a blend of medications that treat skin sores in children and adults aged at least 6 years.

Acyclovir and hydrocortisone creams do not treat or stop the development of cold sores that are caused by herpes. However, it can help lessen the effects of the disease. Topical acyclovir and hydrocortisone are used to treat cold sores that appear on the lips and in the area around them. This medicine is not used to treat lesions caused by herpes that affect the genitals or the eyes.

Topical hydrocortisone and acyclovir can also be used for other purposes that are not mentioned in this guide.

Adverse Effects

Seek medical attention immediately in the event that you exhibit symptoms that indicate an allergy, such as asthma, hives, and swelling of your lips, face, and tongue. Stop using this medication and consult your doctor at the earliest opportunity if you are experiencing intense burning, stinging, or achyness on your treated skin.

Common side effects of acyclovir or hydrocortisone topical could be:

○      minor tingling or burning after application of the medicine

○      skin dryness, flaking, or flaking

○      swelling

○      Skin redness or discoloration

This isn't a complete list of possible side effects, and other effects may also be present. Consult your physician for advice regarding medical adverse effects. You can report symptoms to the FDA at 1-800-FDA-1088.


Follow the directions on the label of your medication and on the label of your package. Inform your healthcare professionals about your medical ailments and allergies, as well as the medicines you are taking.

Before You Take This Drug

Make sure to consult with your doctor. Discuss with your physician if you were ever diagnosed with an insufficient immune system (caused by illness or by taking certain medicines).

Inform your doctor if you are nursing or pregnant.Topical hydrocortisone and acyclovir are not prescription drugs for anyone younger than six years old.

How To Take Hydrocortisone and Acyclovir Topical?

Follow the instructions on the prescription label and also read the medication guides or instruction sheets. Follow the medication precisely as directed.

Take acyclovir or hydrocortisone topical as early as you can after the initial signs or symptoms (such as burning, tingling, itching, or redness). Topical hydrocortisone and acyclovir may cause a negative reaction if you take them in the midst of symptoms. Cleanse your hands prior to or after using the medication. Also, wash the area of your skin that will be treated.

Spread a small amount of hydrocortisone topical cream and acyclovir to cover the sore or tingly spot. Avoid rubbing the cold sore to avoid aggravating it and spreading infection to different parts of your mouth. Don't cover the treated skin with an elastic bandage. Don't put on sunscreen, lip balm, or other cosmetics on the area of soreness that is cold.

Topical application of hydrocortisone and acyclovir is typically applied five times a day for five consecutive days. Follow the instructions of your physician for dosing extremely carefully. Take this medication for the prescribed amount of time, even if symptoms do not improve immediately.

Contact your physician if your symptoms don't improve after two weeks. Keep at room temperature, away from heat and moisture. Don't freeze.

Details on Dosing of Topical Hydrocortisone And Acyclovir

Apply the dosage to the affected area five times per day for five days.
Start treatment as soon as possible following the onset of symptoms or signs (i.e., at the time of prodrome or if lesions begin to appear).
Each dose must be applied in a way that covers the affected area and the outside border.

Use: To aid in the early intervention of persistent herpes laboratoryialis (cold sores), to lessen the chance of developing ulcerative cold sores, and also to speed up the healing time.

Usual Pediatric Dose for Herpes Simplex Labialis: 6-year-olds and older 6 years old or older in the area affected five times a day for five days.
Use: To aid in the early intervention of persistent herpes laboratoryialis (cold sores), to decrease the risk of cold sores that are ulcerative, and to reduce the healing time.

What Happens If I Miss a Dose?

Take the medicine as fast as you can; however, avoid the dose you missed if it is close to time for the next dose. Don't apply two doses at the same time.

What Happens If I Take Too Much?

Acyclovir is a drug that can be abused. Topical hydrocortisone is not likely to occur.

What Should Be Avoided?

Be careful not to let infected areas come into contact with people. Avoid touching an affected area and then rubbing your eyes. Cleanse your hands often to stop the spread of infection.

Don't share acyclovir and hydrocortisone topical products with anyone else, regardless of whether they suffer from similar symptoms to yours. Do not get this medication in your nose, mouth, vagina, or eyes.

Interaction With Other Drugs

The skin care treatment will not be affected by any other medications you take. But there are many drugs that interact with each other. Be sure to inform your health care providers about the medications you take, including those that are prescribed and available over the counter, vitamins, and herbal remedies.