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Name of the generic: Acetylcysteine (oral) (oral) A-SEET-il-SIS-teen“a-SEET-il”-SIS-teen

Terms of brands: NAC, N-A-C Sustain

Dosage forms: oral capsule (500 mg; 600 mg), oral tablet (600 mg)

Drug classes: Antidotes, Mucolytics

What is Acetylcysteine?

Acetylcysteine can be used to reduce or prevent liver damage caused by taking large doses of Acetaminophen (Tylenol).

Various types and brands of Acetylcysteine are available, and some are bought over the counter. Specific forms of Acetylcysteine can be effective as an antidote to acetaminophen. Don't try treatment for an overdose of acetaminophen without medical consultation.

Acetylcysteine is also employed for other purposes not covered in this guideline for medication.


In an emergency, you might be unable to inform doctors about your medical conditions. Be sure that any physician caring for you following the incident knows you have received this medication.

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Prior to Using this Drug:

Acetylcysteine should not be used in case you have an allergy to it.

If it is possible, before receiving Acetylcysteine from your doctor, tell them whether you've ever experienced:

  • A stomach ulcer;
  • The stomach is bleeding or within the stomach or esophagus ( esophageal 1varices);
  • Hypertension, or if you're on an e-diet that is low in salt;
  • Congestive heart failure; or
  • idney disease.

Talk to your doctor before taking Acetylcysteine when you are breastfeeding or pregnant.

In an emergency, you may be unable to inform caregivers whether you're nursing or pregnant. The doctor caring for your baby or expectant mother must know you have received this medication.

How to take Acetylcysteine?

Follow the directions on the label or as recommended by your physician.

Do not consume Acetylcysteine alone if you can't follow the entire instruction.

If you're in a medical emergency before taking Acetylcysteine, your medical professional will run tests on your blood to assess the acetaminophen level within your body. The test is most efficient within 4-8 hours following an acetaminophen overdose. If you cannot recall the last time you consumed acetaminophen or the amount you finished, you will likely receive an initial dose of Acetylcysteine from the beginning.

Your doctor will decide on the length of time you will be treated with Acetylcysteine. Don't stop taking this medication until you are told by your doctor to.

If you vomit within an hour after taking Acetylcysteine, you might need to take a different dose.

Place in a cool, dry place far from heat and moisture.

What Happens If I Miss a Dose?

Do not take the medicine for as long as you are able, but avoid any missed doses if it's nearing the time to take the subsequent amount. Don't have two doses at one time.

What Happens If I Overdose?

Get medical attention in an emergency or contact the Poison Help line toll-free at 1-800-222-1222.

What Should be Avoided?

Follow your doctor's advice regarding any food, drink, or activity limitations.

Side Effects of Acetylcysteine:

See a doctor immediately If you are experiencing symptoms warning signs of an allergic response, such as hives, difficulty breathing, and swelling of your lips, face, and tongue.

Acetylcysteine may cause serious side effects. Consult your physician immediately If you suffer from the following:

Mild Effects:

Severe or ongoing vomiting;

  • Vomit or bloody vomit that resembles coffee grounds, or
  • Indications that the medication may not be adequate: stomach pain, decreased appetite, and black stools, dark urine, jaundice (yellowing of the eyes or skin).

Adverse Effects of Acetylcysteine:

  • Nausea, vomiting, upset stomach.
  • Rash or Fever.

This is not a comprehensive list of all side effects. Other side effects could occur. Contact your doctor to seek medical advice on adverse effects. You can report any side effects to the FDA at 1-800-FDA-1088.

Interaction with Other Drugs:

Other medications may interact with the acetylcysteine level, including medicines prescribed and available over the counter, vitamins, and herbal products. Discuss with your doctor all the medicines you are taking and any medication you begin or stop taking.




Prescription only

Pregnancy & Lactation

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