What is RimabotulinumtoxinB?
Rimabotulinumtoxinb, also known as botulinum toxin type B (myobloc), is produced by the same bacteria that causes botulism. Botulinum toxin temporarily decreases muscle activity by blocking nerve activity.Myobloc can be used to treat dystonia, which is characterized by severe spasms of the neck muscles.Myobloc can also be used to treat sialorrhea, which is chronic drooling.Myobloc can be used in other ways not mentioned in this guide.
Side effects of RimabotulinumtoxinB
If you experience any of the following symptoms of an allergic reaction, seek immediate medical attention: hives, feeling lightheaded, difficulty breathing, swelling of the face, lips, or throat.This medicine contains botulinum toxins that can spread beyond the injection site. Some people who have received botulinum injections for cosmetic reasons or even to treat serious health problems have experienced life-threatening complications. If you experience any of the following side effects, call your doctor immediately (up to a few hours or even weeks after receiving an injection).
- Unusual or severe weakness of the muscles (especially in an area not injected with medication);
- Trouble breathing, speaking, or swallowing
- Hoarseness and drooping of the eyelids
- Double vision, or blurred vision, is another name for this phenomenon.
- Loss of bladder control
- Problems with vision
- Chest pain.
Rimabotulinumtoxin B can cause a variety of side effects.
- Pain or discomfort at the injection site;
- Headache;
- Dry Mouth;
- Trouble swallowing
There may be other side effects. Call your physician if experiencing side effects. For medical advice regarding possible adverse reactions. The FDA can be contacted at 1-800-FDA-1088 to report side effects.
Similar/related drugs
Botox, onabotulinumtoxina, Daxxify, Xeomin, Dysport, abobotulinumtoxina, Myobloc
Warnings
This medicine should not be given to you if your skin is infected with it or you are allergic. This medication contains botulinum toxins that can spread beyond the injection site. This can have serious and life-threatening effects. If you experience hoarseness, drooping eyes, vision problems, or severe muscle weakness, or if you are having difficulty breathing, talking, or swallowing, call your doctor immediately. These effects may occur several weeks after the botulinum injection.
Before you take this drug
Myobloc should not be used if the patient is allergic to botulinum toxins or has an infection near the injection site. Tell your doctor if, in the past, you experienced a side effect after receiving botulinum toxins.
Inform your physician of any of the following issues:
- Other botulinum injections, such as Botox dyssport or Xeomin,
- Lou Gehrig’s disease, or amyotrophic lateral sclerosis
- Myasthenia gravis;
- Lambert-Eaton syndrome;
- A breathing disorder such as asthma or emphysema
- Droopy eyelids
- Problems with swallowing
- Bleeding problems
- Face surgery
- If you plan to undergo any type of surgical procedure,
Myobloc, which is made of donated plasma from humans, may contain viruses and other infectious agents. Plasma donated is treated and tested to reduce the chance of contamination. However, there is still some risk that it may transmit disease. You should ask your doctor if there are any risks. This medicine is not known to harm an unborn child.Inform your physician immediately if you are pregnant or planning on becoming pregnant. Breastfeeding may not be possible while taking this medication. For your own health's sake, always seek medical advice when facing risks or uncertainties.
How to take RimabotulinumtoxinB?
This medicine is injected either into muscular or glandular tissue. This injection will be given by your healthcare provider once every 12–16 weeks. Myobloc should be given at least three months apart. You may need to inject more than one part at a given time, depending on the condition you are treating. Myobloc's effects are only temporary. You may experience a complete recurrence of your symptoms within three months following an injection. Once repeated injections begin to have their effects, your symptoms could return much quicker.This is especially true if you develop antibodies against the botulinum toxins. Avoid requesting botulinum injections from multiple medical professionals at the same time. Tell your new healthcare provider when you last received a botulinum injection. This medicine will not be more effective if you take it more than the prescribed amount. However, they could lead to severe side effects.
Details on dosage
Adult dose for cervical dystonia:
Patients who tolerated botulinum toxins:
Initial dose: 2500-5000 units divided between affected muscles
Patients who do not tolerate botulinum toxins:
Lower initial doses of a drug are recommended.
The dosage should be adjusted based on the patient's response.
-Duration: 12-16 weeks (at doses ranging from 5000-10000 Units)
Comments:
This drug should only be administered by doctors who are familiar with and have experience in the assessment and treatment of cervical dystonia.
Use: Reduces the severity of neck pain and abnormal head positions associated with cervical dystonia.
Adult dose for sialorrhea:
Initial dose: 1500–3500 units divided between the parotid glands and submandibular ducts
Parotid: 500–1500 units per gland
Submandibular: 250 units per gland
The patient's response should determine the next dose. The typical duration of each treatment can be up to three months, but it may vary from one individual to another.
Treatment frequency: In general, not more than 12 weeks.
Comments:
Consult the package labeling to get additional instructions on administration, including an illustration of where the glands should be placed.
In clinical trials, anatomical landmarks as well as ultrasound guidance were used to locate the glands. Both methods resulted in a similar reduction in unstimulated flow rates.
Use: To treat chronic sialorrhea.
What happens if I miss the dose?
Missing a dose of botulinum is unlikely to cause harm, as the toxin is only temporary and given at widely separated intervals.
What happens if I overdose?
Contact 1-800-222-1222 immediately in case of poison exposure and seek emergency medical care if necessary.
The symptoms of an overdose may not be apparent immediately, but they can include muscle weakness or difficulty swallowing, shallow or weak breathing, and loss of movement anywhere on your body.
What should be avoided?
Myobloc can impair depth perception or vision. You should be careful when driving or doing anything else that requires clear vision.
Interaction with other drug
Tell your doctor about your other medications, including:
- A muscle relaxer;
- Medicine to treat an infection
- Medicine to treat depression or anxiety;
- Cold or allergy medication (Benadryl et al.)
- Medicine to treat Parkinson’s disease
- Medicine to treat stomach problems, motion sickness, or irritable bowel syndrome
- Medicine to treat overactive urinary bladder
- Asthma medication bronchodilator.
This list is incomplete, and other drugs can also affect Myobloc. This includes over-the-counter and prescription medicines, vitamins, and herbal products. This list does not include all possible drug interactions.
