What is Lumasiran?
Lumasiran can be used to treat a form of hyperoxaluria, which is a condition in which your urine contains high levels of oxalate. Oxalate is found in foods and the human body. Urine with too much oxalate can lead to kidney stones or renal failure.Lumasiran can be used by adults and children alike.Lumasiran can be used in other ways not mentioned in this guide.
Side effects of Lumasiran
If you experience any of the following signs and symptoms of an allergic reaction: hives, difficulty breathing and swelling in your face, lips or throat - please seek medical assistance immediately!Some of the most common side effects include redness, itching, or swelling at the injection site.There may be other side effects. For medical advice on side effects, call your doctor. Contact the FDA by calling their hotline: 1-800-FDA-1088 if experiencing side effects from medication.
Warnings
It may be necessary to adopt a special eating plan to control your condition.
Before you take this drug
Inform your physician if you are expecting or nursing.
How to take Lumasiran?
Lumasiran injections are given under the skin.This injection will be administered by a healthcare provider.Lumasiran can be given every 1 to 3 weeks.Lumasiran dosages are determined by weight. If your child loses or gains weight, the dose needed by your child may change.Diet may be required in some instances. You should follow the instructions given by your doctor or dietitian. Learn which foods you should eat and avoid in order to control your condition.
Details on dosage
Adult dose for primary hyperoxaluria:
Minimum 20 kg
Loading dosage: 3 mg/kg once a month subcutaneously for 3 doses
Maintenance dosage: 3 mg/kg percutaneously every three months (quarterly).
Use: To lower plasma and urinary oxalate concentrations in primary hyperoxaluria type 1 (PH1).
The usual paediatric dose for primary hyperoxaluria is
Weighing less than 10 kg
Loading dosage: 6 mg/kg once a month subcutaneously for 3 doses
Maintenance dosage: 3 mg/kg once a month subcutaneously
10 kg and less:
Loading dosage: 6 mg/kg once a month subcutaneously for 3 doses
Maintenance dose: 6 mg/kg subcutaneously, every 3 months.
Minimum 20 kg
Loading dosage: 3 mg/kg once a month subcutaneously for 3 doses
Maintenance dosage: 3 mg/kg percutaneously every three months (quarterly).
Use: To lower plasma and urinary oxalate concentrations in PH1.
What happens if I miss the dose?
If you are unable to attend your appointment, call your doctor and ask for instructions.
What happens if I overdose?
Overdoses are unlikely because lumasiran will be administered by a health professional in a medical environment.
What should be avoided?
If your doctor prescribes any restrictions regarding food, beverage, or activity, follow their instructions.
Interaction with other drug
Other drugs, such as vitamins and herbal products, may also affect lumasiran. Inform your doctor of all the medicines you are taking and those that you stop or start using.
