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Can melatonin cause depression?


Melatonin is a hormone that your brain naturally produces when it’s dark outside. Due to the production of melatonin, you naturally feel more tired as night approaches. Some people cannot produce enough melatonin naturally, so they take melatonin supplements to help them sleep. In addition, melatonin can cause several side effects, including:

  • anger
  • dizziness
  • Confused
  • worried
  • Watch out

During the day, melatonin levels are lower. But when it gets dark, your optic nerve sends a signal to your basal clock, telling your brain to start producing melatonin. You start to sleep because of the increase in melatonin in your blood.

Because of its ability to regulate your sleep-wake cycle, melatonin has become a popular supplement to improve sleep and treat a variety of sleep-related problems, including:

  • plane back
  • insomnia
  • shift work sleep disorder
  • delayed sleep phase disorder
  • circadian rhythm sleep disorder
  • wake

How does melatonin works in the body?

One of the main functions of melatonin is to regulate our biological rhythm. There are two different melatonin production pathways: pine and pine supplements.

Some studies show that it can help or overcome symptoms related to depression. But it can also happen.

Synthesis of Pineal Melatonin

Synthesis of pineal melatonin occurs in the pineal cortex of the brain. This process usually starts two hours after midnight and is called “the beginning of dark melatonin”. Other external stimuli, such as eating patterns, leisure and social activities, also influence this pathway. Melatonin circulates outside the body from the pineal gland, transmits information about light and darkness, and regulates daily routines. Melatonin plays an important role in regulating biological rhythms. Biological rhythms determine when certain body functions and behaviors occur and stay “in time” with the outside world.

However, the effects of melatonin on our behavior are complex. The production of melatonin can be influenced by behavior – for example, by the desire to sleep – and our behavior can affect the production of melatonin by determining our light, diet and activity.

Additional pineal melatonin synthesis

Excess synthesis of pineal melatonin occurs in other parts of the body, including the skin, intestines, and lungs. The excess of pine melatonin is only locally without any special effects on our biological rhythms.

Melatonin, biological rhythms and depression

A study found that disrupting circadian rhythms in mice (affecting the suprachiasmatic nucleus) leads to weakness, behavioral despair, and anxiety-like symptoms. Another study found that mice exposed to 22-hour light and dark periods developed symptoms of depression, including increased depression and immobility.

Clinical trials in humans have revealed that abnormalities in biological rhythms occur in a variety of clinical conditions, including obesity, diabetes, and cancer. Changes in biological rhythms are also associated with mood swings – especially when depressive symptoms can come with the seasons in a condition known as seasonal affective disorder (SAD). Additionally, people with depressive disorders report mood swings with the time of day.

Altered melatonin production can disrupt our biological rhythms, causing these mood swings. Meanwhile, in people living with depression, the drop in serotonin levels can affect the pineal’s production of melatonin, which can cause mood swings.

Melatonin and Dopamine

Melatonin regulates dopamine signaling in certain brain regions. Dopamine is a hormone that affects the production of hormones that affect mood such as noradrenaline and mood. Abnormal melatonin levels can affect dopamine signaling, causing changes in mood and behavior

Melatonin and the immune system

Concentrations of the stress hormone cortisol are associated with inflammatory responses to robust melatonin synthesis (but not concentrations associated with unexpected chronic mild stress).

During innate immunity, melatonin helps send white blood cells from the bone marrow to the blood and blood to the site of injury. Melatonin levels must return to baseline in order for your body to recover from the effects of inflammation and return to normal function.

Researchers have found increased neuroinflammatory responses in a range of neurodegenerative and psychiatric disorders, including major depressive disorder. Animal studies have shown that melatonin treatment significantly reverses some inflammatory effects and reduces depressive symptoms.

These studies suggest that melatonin treatment may have antidepressant effects.

Is melatonin good for sleep – and what should I know about melatonin side effects?

The hormone melatonin plays an important role in the sleep-wake cycle. The natural level of melatonin in the blood is highest at night. Some research suggests that melatonin supplements can help treat sleep disorders. It can also provide some relief from insomnia and jet lag.

Melatonin is generally safe for short-term use.  The most usual after effects of melatonin are:

  • brain
  • dizziness
  • worried
  • Take a nap

Less usual melatonin after effects may comprise of:

  • Lucid dreams or nightmares
  • Feelings of short-term depression
  • Stomach ache
  • Do not have diarrhea
  • intestine
  • job loss
  • Urinary incontinence at night
  • Increased risk of falling
  • Increased risk of seizures
  • Confused or confused
  • Mood swings
  • Reduce alertness

Melatonin supplements may interact with several types of medications:

  • Medicines that slow blood clotting
  • Anticonvulsant drugs
  • Birth control pills
  • High blood pressure medicine
  • Diabetes

Before taking melatonin supplements, check with your healthcare provider, especially if you have a medical condition or are taking other medications. Over-the-counter melatonin supplements vary in the amount of melatonin they contain.

Remember, as with any supplement, melatonin should not be the first or only medication you use to treat a health problem such as insomnia. It should be combined with lifestyle habits that create a solid foundation for health. This includes basics like good nutrition, daily exercise, daily mind-body routine, good sleep hygiene, social connection and spirituality.

What is depression?

The state of depression can be manifested as a variety of behavioral and psychological symptoms and changes in body functions. It can be a lack of pleasure, a sense of futility, or sleep disorders.

Depressive episodes can be a symptom of many mental disorders, including bipolar disorder, major depressive disorder (MDD), and seasonal affective disorder (SAD).

Can melatonin cause depression?

There is no evidence that melatonin causes depression in people without a history of depression. A recent 2016 review of melatonin research found no serious side effects associated with melatonin use.

But some people experience side effects. Usually, this includes mild dizziness, nausea, or insomnia. Some people also face the following:

  • confusion
  • anger
  • short term depression

Until recently, it was thought that taking melatonin could cause temporary symptoms of depression. But it will not cause others to show chronic symptoms typical of the diagnosis of major depressive disorder.

Consumption of melatonin, especially in large amounts, can mimic some symptoms of depression. Consider the side effects of melatonin use. Patients may feel tired, which is a common symptom of depression. Some patients who take melatonin to help them sleep may feel groggy or jittery the next day.

Normally, melatonin is only present in the body for about five hours. However, some patients may have persistent symptoms. Taking melatonin at the wrong time can cause patients to experience long-term symptoms.

However, if taken incorrectly, it can often worsen some symptoms associated with depression. This includes taking too much melatonin or taking the medication at the wrong time.

Can Melatonin Improve Depression?

The relationship between melatonin and existing depression is not yet understood. A small study from 2002, Trusted Source, shows that people with depression can have high levels of melatonin

Remember that melatonin prepares your body for sleep. It makes you stronger, which is a common symptom of depression. If you experience low energy as a symptom of depression, taking melatonin can make it worse.

Although short-term depressed mood is a rare but possible side effect of melatonin, it is not known whether it can cause severe symptoms in people who have been diagnosed with depression. Additionally, many people who take melatonin, including people with depression, do not experience these side effects.

In some cases, taking melatonin may improve symptoms of depression compared to a placebo. For example, melatonin may be more useful in treating seasonal depression than in treating major depressive disorder.

Can Melatonin Help Depression Symptoms?

To make matters worse, there is some evidence that melatonin can reduce the risk of depression in some groups and improve depressive symptoms in others.

For example, a small 2014 study in Sumber Dipercaya found that melatonin can reduce the risk of depression three months after breast cancer.

Additionally, a small 2006 study found that melatonin may be more beneficial for seasonal affective disorder (SAD), a type of depression based on seasonal patterns. For example, many people with sadness experience depression during short months and short days.

The researchers behind the study found that circadian rhythms are an important factor in seasonal depression. Taking low doses of melatonin seems to help resolve the disorder and reduce symptoms.

While all of this research is promising, there is not enough evidence to support that taking melatonin helps with depression symptoms. Larger studies are needed.

While melatonin may not directly cure your depression, it may help you get into a regular sleep pattern, which may improve some of your symptoms.

Increased risk of depression

Melatonin may also alter natural wake/sleep patterns and improve circadian rhythm disturbances in some patients.

Before you decide to use melatonin, you should probably consult your doctor. A professional doctor can help you decide if melatonin is right for you or if it might make your symptoms worse.

Can melatonin make you depressed?

Modern science is not yet clear about the relationship between melatonin and depression. Some studies have shown that melatonin levels may increase in depressed people. Patients with major depressive disorder appear to produce more melatonin at night. When patients resolve major depressive symptoms, melatonin production may decrease.

However, this does not mean that melatonin can directly cause depression. Conversely, nocturnal melatonin secretion may be an indicator of major depressive disorder in some patients.

If you are considering taking melatonin to help you sleep, you should be aware of its effects on depression. Taking melatonin may improve short-term depression symptoms. Melatonin supplements are designed to make you sleepy and make it easier to fall asleep.

Unfortunately, depression can often drain your energy. If you take melatonin, it can make you more tired and sleepy during the day.

Seasonal affective disorder/Seasonal Depression and Melatonin

Seasonal depressive disorder is often caused by circadian rhythm imbalances. Patients with circulatory imbalances may experience a variety of symptoms, including a significantly increased risk of depression. For patients suffering from this circadian imbalance, taking melatonin can help resolve some depressive symptoms. This is because the medication can help patients regulate their circadian rhythms better and sleep better at night.

Circadian Dysfunction, Depression, and Melatonin

Many patients suffer from sleep disorders due to depression. Chronic sleep deprivation, including chronic insomnia, can significantly increase the risk of depression. It can also cause significant vinegar incompatibility, which can help make it more difficult to work with.

Taking melatonin can help manage some of these sleep disorders and make it easier for patients to fall asleep. It can also improve some other symptoms of depression. Melatonin is a useful tool in the treatment of patients suffering from insomnia.

How can melatonin affect depression?

Scientists have determined that depressive conditions, such as mood disorders, are linked to imbalances in hormones and neurochemicals such as serotonin and dopamine. Recent studies have found that mismatches in biological rhythms may contribute to this imbalance.

Bottom line

The relationship between melatonin and depressive symptoms is unclear. For some it seems to help, but for others it can make the situation worse. If you want to try it, make sure you start with a low dose and pay attention to your mind and body as you take it.



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