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Generic Name: Hydrochlorothiazide and lisinopril [HYE-droe-KLOR-oh-THE-azide-and-lye-SIN-oh-pril]
The Class of Drug: ACE inhibitors with thiazides

What is Zestoretic?

Zestoretic includes a mix that consists of hydrochlorothiazide and lisinopril. Hydrochlorothiazide is a diuretic thiazide (water tablet) that helps prevent your body from taking in excessive amounts of salt, which may result in fluid retention.

Lisinopril falls under the category of an ACE inhibitor. ACE stands for angiotensin-converting enzyme. Lisinopril decreases blood pressure. It helps relieve the symptoms associated with fluid retention.

Zestoretic can be used to treat hypertension (high blood pressure). The reduction in blood pressure could reduce the chance of suffering a stroke or cardiac attack.Zestoretic could also be used to treat conditions not covered in this medication guide.


Avoid using Zestoretic in the event that you are expecting. If you find yourself pregnant, discontinue taking this medication and inform your doctor as soon as you can.

You shouldn't make use of Zestoretic. If you've ever experienced angioedema, if you're not able to urinate, or if you're intolerant to sulfa medicines or all ACE inhibitors, Don't take hydrochlorothiazide or lisinopril within 36 hours immediately prior to or shortly after taking prior to or after taking a medication that contains sacubitril (such for Entresto).

If you are diabetic, don't take Zestoretic along with any other medicine that includes an ingredient called aliskiren (a blood pressure medication).

Before you take this drug

It is not recommended to use Zestoretic in the event that you are allergic to hydrochlorothiazide, lisinopril, or hydroch or if you suffer from:

  • If you are suffering from angioedema that is hereditary,
  • You are not able to go to the bathroom.
  • Recently, you have taken the medication for heart disease sacubitril.
  • You are allergic to sulfa-containing drugs
  • If you've ever experienced an extremely severe allergy to one of the ACE inhibitors (benazepril, fosinopril, or captopril), moexipril, perindopril, quinapril, ramipril, or trandolapril,

Take care not to consume Zestoretic in the first 36 hours prior to or after taking medication that includes sacubitril (such as Entresto).

If you suffer from diabetes, avoid hydrochlorothiazide as well as lisinopril in conjunction with any other medicine that has aliskiren (a blood pressure medication).

You might also have to steer clear of taking Zestoretic with the aliskiren in the event that you suffer from renal disease.

To ensure that Zestoretic is suitable for you, inform your doctor that you suffer from:

  • Kidney disease (or if you're taking dialysis);
  • Cirrhosis or any other liver disease;
  • Glaucoma;
  • Congestive heart failure;
  • Asthma or allergies;
  • Gout;
  • Lupus;
  • An allergy to sulfa medications or penicillin
  • If you're on a diet that has low salt.

Don't use it if you are expecting. Stop taking the medicine and inform your doctor right away if you discover that you are pregnant. Lisinopril can cause injury or even death to an unborn baby if taken in your third or second trimester.

It is not recommended to breastfeed during treatment with hydrochlorothiazide and lisinopril.

Zestoretic isn't approved for use by anyone less than 18 years old.

Similar or related drugs

amlodipine, lisinopril, metoprolol, losartan, furosemide, carvedilol, and hydrochlorothiazide

How to take Zestoretic?

You should take Zestoretic exactly as directed by your physician. Follow all instructions on your prescription label and review all medication guides or instruction sheets. The doctor might alter your dosage.

Contact your physician if you are experiencing persistent nausea or diarrhea or are sweating more frequently than normal. It is possible to get dehydrated while taking this medication. This can result in high blood pressure, electrolyte issues, or kidney failure.Your blood pressure needs to be checked regularly as well as through periodic blood tests.If you require surgery, inform your doctor that you are currently taking this medication.

Continue to take this medicine as prescribed, even if you do not feel well. High blood pressure is often accompanied by no signs. It could be necessary to take blood pressure medications throughout your life.Maintain at room temperature and free of heat, moisture, and light.

Details on dosage

Usual Adult Dose for Hypertension:

Initial dose Hydrochlorothiazide 12.5 mg and Lisinopril 10, 10, or 20 mg are taken orally daily in accordance with the dose of monotherapy currently being used.
Maximum dose: hydrochlorothiazide 50 mg and lisinopril 80 mg per day
May increase dosage every 2 to 3 weeks.
If blood pressure is managed by monotherapy with hydrochlorothiazide, 25 mg daily, and significant loss of potassium occurs, it is possible that a similar or better blood pressure control with no electrolyte disturbance could be achieved by using hydrochlorothiazide (12.5 mg) and lisinopril (10 mg) orally every day.

What happens if I miss the dose?

Do not take the medicine for as long as you can. However, avoid any missed doses if you are nearing the time to take the next dose. Don't take two doses at a time.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

Hydrochlorothiazide can increase the chance of developing skin cancer. Avoid tanning beds or sunlight. Protect yourself with clothing that is breathable and sunscreen (SPF 30 or more) while you're outdoors. Your physician may ask you to take skin tests every few months.Drinking alcohol may increase your blood pressure and can also cause an increase in certain adverse consequences of this drug.

Do not take salt substitutes or potassium supplements during the time you are taking this medication, unless your doctor has advised you to.Be careful not to get up too fast from a lying or sitting position, as you could get dizzy.

Avoid becoming too hot or dehydrated when exercising, in hot weather, or simply by not drinking enough fluids. Follow the instructions of your doctor regarding the types and amounts of fluids you must consume. In some instances, drinking too much liquid could be as harmful as drinking too little.

Side effects of Zestoretic

See a doctor immediately. If you exhibit indications or warnings of a reaction allergic to Zestoretic, such as hives and stomach pains that are severe, breathing difficulties, and swelling of your lips, tongue, throat, or face, You are more likely to experience reactions to Zestoretic if you are African-American.

Contact your doctor immediately. If you are suffering from:

  • A feeling of lightheadedness, as if you've passed out;
  • Eye pain, vision problems;
  • Very little or no urine;
  • Fatigue, sleepiness, or feeling restless;
  • The fever, chills, sore throat, mouth sores, and difficulty swallowing
  • Jaundice (yellowing of the eyes or skin);
  • High Potassium high potassium, nausea sensation, tingling chest pain, irregular heartbeats, loss of movement;
  • Low potassium causes leg cramps, constipation, irregular heartbeats, fluttering of the chest, and an increase in thirst or urination. You may also experience numbness, tenderness in the muscles, or a feeling of limpness.
  • Low sodium, low sodium headache headache, confusion, poor speech, extreme weakness, vomiting, loss of coordination, feeling shaky

Side effects common to Zestoretics could include:

  • Cough;
  • Headache;
  • Dizziness;
  • Fatigued feeling.

This isn't a complete list of all the side effects. Other side effects could occur. Consult your physician for advice regarding medical adverse effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Discuss with your doctor any other medications you take, particularly:

  • Other blood pressure medications;
  • Lithium;
  • Everolimus, sirolimus, or temsirolimus;
  • Nonsteroidal anti-inflammatory medications such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and more

This list isn't complete. Other drugs can be incompatible with hydrochlorothiazide or lisinopril, including prescription and over-the-counter drugs, vitamins, and herbal products. There are many possible interactions between drugs, which are included here.



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