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Sleep-ettes D

Generic name: Diphenhydramine
Drug Classes: anticholinergic antiemetics; anticholinergic antiparkinson agents; antihistamines. Miscellaneous Anxiolytics. Sedatives and hypnotics

What is Sleep-ettes D?

Sleep-ettes D antihistamine is used for sneezing and other allergy or cold symptoms such as hives, rash, itching, and skin rashes.

Sleepettes D can also be used to treat motion sickness and induce sleep. It is also prescribed to treat some symptoms of Parkinson’s disease. This sleep medicine is not recommended for children under 12 years of age. Diphenhydramine is available in many different brands and forms. This leaflet does not list all brands. This medication guide does not list all possible uses for Sleep-ettes D.

Side effects of Sleep-ettes D

If you experience any of the following signs and symptoms of an allergic reaction: difficulty breathing, hives, swelling in lips, face, tongue or throat and difficulty swallowing (delayed breathing), seek medical assistance immediately: difficulty in taking in air.

Sleep-ettes D may cause serious side effects. Sleep-ettes D should be stopped immediately, and you should consult your doctor if:

  • Severe sleepiness
  • Urination that is painful or difficult

In older adults, side effects like dryness of the mouth and constipation may be more common.

Sleep-ettes D can cause the following side effects:

  • Drowsiness;
  • Dry eyes and blurred vision
  • Dry mouth, nose, or throat
  • Reduced urination
  • Constipation;
  • Feeling restless or excited, especially in children
  • After nighttime use, you may feel drowsy or have a "hangover".

There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.

Similar/related drugs

Lorazepam, Melatonin, Zolpidem, Diphenhydramine, Ativan, and Ambien


Sleep-ettes D should be used exactly as instructed. Too much sleep can cause serious heart problems. It may also lead to seizures, coma, or even death. This sleep-aid medicine should not be used in children under 12 years of age.

Before you take this drug

Sleep-ettes D should not be used if you have an allergy to them.

If you have had any of the following:

  • Urination or prostate problems;
  • Asthma, chronic obstructive lung disease (COPD), and other breathing disorders;
  • Glaucoma;
  • A thyroid disorder.

Before using Sleep-ettes D, consult your doctor if you're pregnant or nursing. This medicine may reduce breast milk production.

How to take Sleep-ettes D?

Sleep-ette D should only be used as directed by your doctor or on the label. Sleep-ettes D should only be used for a short time until symptoms are resolved. Too much sleep can cause serious heart problems. It may also lead to seizures, coma, or even death. Follow the directions on the label when giving Sleep-ettes to a child. Do not use this medicine to make your child sleepy. Misuse of antihistamines can lead to death in young children.

Take Sleep-ettes D for motion sickness 30 minutes before you are in a situation that will cause you motion sickness. (For example, a long ride in a car, an airplane or boat trip, rides at amusement parks, etc.) Take this medicine at mealtimes and before bedtime until you are no longer in a situation that causes motion sickness. Sleep-ette D can be taken 30 minutes prior to bedtime as a sleep aid.

The chewable tablet must be chewed before it can be swallowed. Measuring liquid medicine is important. Use the provided dosing device or a dose-measuring tool (not a spoon). Only remove an oral disintegrating tablet when you're ready to use it. Place the tablet in your mouth without chewing. As the tablet dissolves, you should swallow it several times.

If you experience a fever, a headache, or a skin rash, call your doctor. Sleep-ettes D should not be used for more than two weeks to treat sleep disorders or seven days to treat colds or allergy symptoms. Allergy skin tests can be affected by Sleepettes D. Inform any doctor that you see about Sleep-ettes D. Store away from heat and moisture at room temperature.

What happens if I miss the dose?

Sleep-ettes D can be taken as needed. You may not have a regular dosing regimen. If it is almost time for the next dose, skip any missed dose. Never take two doses in one go.

What happens if I overdose?

Call Poison Help at 1-800-222-1222 or seek emergency medical care. A diphenhydramine overdose can be fatal. Overdose symptoms include agitation and hallucinations.

What should be avoided?

Sleep-ettes D can affect your reaction to driving and other hazardous activities. You may be unable to react properly. Diphenhydramine can be exacerbated by alcohol.

Before using any other medication that contains Sleep-ettes D, consult your doctor or pharmacist. This includes medications for sleep, cold or allergy symptoms, or anti-itch medicines used on the body. Too much of this medicine can lead to an overdose.

Interaction with other drug

Before using Sleep-ettes D, consult your doctor or pharmacist. This is especially important if you are taking any medications that may cause drowsiness, such as an opioid, a sleep medication, a muscle relaxation medicine, or medicine to treat anxiety or seizures. Inform your doctor of all the medicines you are currently taking and those that you have started or stopped using. Included are prescription and over-the-counter medicines, vitamins, and herbal products. This list does not include all possible interactions.