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Generic name: edoxaban [e-DOX-a-ban]
Drug class: Factor Xa inhibitors

What is Savaysa?

Savaysa blocks the activity of certain clotting agents in the blood.Savaysa is a medication used to decrease the risk of stroke triggered by a clot in the blood in patients who suffer from a heart-rhythm disorder referred to as atrial fibrillation. The medicine is prescribed in cases where the atrial fibrillation is not due to an issue with the heart valve.

Savaysa can also be utilized to treat a form of blood clot known as deep vein thrombosis (DVT), which could cause blood clots to form in the lung (pulmonary embolism). Savaysa is best used within 5 to 10 days after the use of blood thinners that can be injected.


Savaysa may cause you to be more susceptible to bleeding. Consult your physician immediately if you notice symptoms of bleeding, such as bleeding gums, bleeding noses, heavy menstrual cycles or vaginal bleeding that is abnormal, the presence of blood in urine and stools that are bloody or tarry, coughing blood, or vomit that appears to be coffee grounds.

Other medications can also increase the bleeding risk if used together with Savaysa. Inform your doctor about any medications you've recently taken.

Savaysa could cause a dangerous blood clot in your spinal cord when you are treated with an examination of your spinal cord or spinal anesthesia (epidural). Tell your doctor to know that you're taking this medication.Don't discontinue taking Savaysa without consulting your physician.In the event that you cease abruptly it may increase the chance of having a stroke or blood clot.

Prior to use this drug

You shouldn't take Savaysa in the event that you are allergic to edoxaban or suffer from uncontrolled or active bleeding.

Savaysa could cause a severe blood clot to your spinal cord when you have the procedure of a spinal tap or some form of spinal anesthesia (epidural). This kind of blood clot can cause long-term paralysis. It is more likely to happen in the following situations:

  • If you suffer from an inherited spinal defect
  • There is a spinal catheter in place.
  • You have an existing history of spine surgery or multiple spinal taps.
  • You have had a recent epidural or spinal tap.
  • You're in the process of taking an NSAID that includes such things as Advil, Aleve, Motrin, and others.
  • You are taking other medications to prevent or treat blood clots.

Savaysa could cause you to bleed more frequently, particularly in the case of:

  • A hemorrhage that is genetic or caused by a disease
  • Hemorrhagic stroke;
  • Uncontrolled excessive blood pressure;
  • The stomach, intestinal or other bleeding, or an ulcer
  • If you take certain medicines like enoxaparin, aspirin, or warfarin (Coumadin, Jantoven), the drug clopidogrel (Plavix) or antidepressants

Inform your doctor if you have ever suffered from:

  • An artificial heart valve
  • Bleeding issues as well as
  • Kidney or liver disease.

Edoxaban taken during pregnancy can cause bleeding in the mother as well as the unborn child. Tell your doctor whether you are pregnant or not.It is not recommended to breastfeed when taking edoxaban.

How to take Savaysa?

You should take Savaysa exactly as recommended for you. Follow all instructions on your prescription label, and review all medication guides or instructions sheets. Your doctor may alter your dosage. Make sure you take the medicine precisely as prescribed.The function of your kidneys may require checking prior to starting this medication.

You may consume Savaysa either with or without meals.If you can't take a tablet whole, crush it, then combine it with 2 to 3 tablespoons of applesauce or water. Take the mixture in one go, without chewing. Don't save it for later time.Savaysa could help you lose blood even from a minor injury. Seek medical attention when you experience bleeding that does not stop.

If you require dental surgery, surgery, or medical treatment, be sure to inform the dentist or doctor beforehand that you're taking this medication. If you require anesthesia, you might need to stop taking Savaysa for a brief period of time.Do not alter the dosage or stop using this medication without consulting your physician. Stopping suddenly can increase the risk of a blood stroke or clot.Keep it at room temperature, free of heat and moisture.

Dosing information

Usual Adult Dose for Atrial Fibrillation:

60 mg orally, once a day
Use: Preventing stroke and embolism systemic in nonvalvular atrial fibrillation.

Usual Adult Dose for Deep Vein Thrombosis:

60 mg taken orally every day after 5 to 10 days of treatment using a parenteral anticoagulant; your dosage may be reduced in the case of a lower weight.
Uses: Treatment for deep vein thrombosis and pulmonary embolisms following 5–10 days of the initial anticoagulant therapy with a parenteral agent

Usual Adult Dose for Pulmonary Embolism:

60 mg once orally, every day, following 5–10 days of the initial treatment with an anticoagulant that is administered via a parenteral route; your dosage may be reduced when you are of low weight.
Treatment of deep vein embolism and pulmonary thrombosis following 5–10 days of the initial anticoagulant therapy for the parent

What happens if I miss the dose?

Do not take the medicine for as long as you are able, but do not take your missed dosage if it's nearing the time to take the next dose. Don't have two doses at one time.

Make sure you refill your prescription before the expiration date of your medication.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.An overdose may cause excessive bleeding.

What should be avoided?

Avoid activities that increase the chances of sustaining injuries or bleeding. Make sure you take extra precautions to avoid bleeding when shaving or brushing your teeth.

Side effects of Savaysa

Take immediate medical attention. If you are experiencing symptoms that indicate an allergy reaction, Savaysa: hives, breathing difficulties, or swelling of your lips, face, and tongue.

Get medical attention immediately in the event that you exhibit signs of a spinal blood clot: back pain as well as numbness or weakening in the lower part of your body or loss of control over your bladder or bowel.

Savaysa could cause bleeding to occur more frequently. Consult your physician immediately if you show symptoms of bleeding, like:

  • Bleeding or easy bruising (nosebleeds, bleeding gums, excessive menstrual bleeding);
  • Swelling, pain, and drainage of a cut or where a needle has been placed in your skin
  • Bleeding from wounds or injections, or any bleeding that isn't stopping;
  • Headaches, dizziness, weakness, the feeling that you're going to faint;
  • Urine that appears pink, red, or brown;
  • Bloody or tarry stool and coughing up blood, or vomit that appears like coffee grounds.

Common Savaysa side effects can include:

  • Bleeding
  • The red blood cell count is low (anemia); pale skin; unusual tiredness; feeling lightheaded or tired; cold feet and hands.

This isn't an exhaustive list of possible side effects, and others could happen. Consult your physician to seek medical advice on adverse effects. You can report symptoms to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Discuss with your doctor all other medications, including:

  • Other medications that stop or treat blood clots
  • Is a bleeding thinner, warfarin heparin (Coumadin, Jantoven);
  • Nonsteroidal anti-inflammatory medicines like, for example, aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others;
  • Antidepressant citalopram, duloxetine, fluoxetine and sertraline, paroxetine and venlafaxine, Cymbalta, Prozac, Pristiq, Paxil, Zoloft, and more.

This is not a complete list, and other drugs could be incompatible with edoxaban. This includes over-the-counter and prescription drugs, vitamins, and herbal supplements. There are many possible interactions between drugs, which are listed here.



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