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S2 Inhalant 

Generic term: Racepinephrine (RAISE-epi-NEF-rin).

Brand name: Asthmanefrin, S2 Inhalant
Drug class: Adrenergic bronchodilators 

What is S2 Inhalant? 

S2 inhalant acts as a bronchodilator. It relaxes muscles in the airways and lungs to aid breathing.  S2 inhalant can be used to treat occasional signs that are common to asthma symptoms, like wheezing, chest tightness, and feeling breathless.  S2 inhalant could also be used to treat conditions not covered in this guideline.

Side Effects of S2 Inhalant

Contact a medical professional immediately. If you are experiencing symptoms that indicate an allergic reaction, such as difficulty breathing, hives, or swelling of your lips, face, and throat,  S2 inhalants can cause serious adverse side effects. Contact your physician immediately. If you suffer from: acute or new symptoms of asthma; a high heart rate or tremors; a nerve-stricken feeling; sleep problems (insomnia); a seizure (convulsions); or very high blood pressure (severe migraine); blurred vision the pounding of your neck or ears, nosebleeds anxiety, confusion, extreme discomfort in your chest, the feeling of breathing becoming short, and irregular heartbeats. This isn't a complete list of possible side effects, and other side effects could be present. Consult your physician to seek medical advice on adverse effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.


Do not take S2 inhalants when you've taken an MAO inhibitor in the last 14 days, including isocarboxazid, linezolid blue injection, phenelzine, selegiline, rasagiline, or tranylcypromine.

Before you take this drug

Do not take S2 inhalant unless you suffer from an asthma diagnosis that is confirmed by your physician.  It is not recommended to take S2 inhalant if you are sensitive to it.  Do not take S2 inhalant if you have previously taken an MAO inhibitor within the last 14 days. A potentially dangerous interaction with a drug could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, rasagiline, and phenelzine, as well as tranylcypromine.  Speak with a pharmacist or doctor to determine if it's safe to take this medication in the event of other medical issues, particularly: heart disease; high blood pressure; diabetes; a thyroid disorder; and mental illness, also known as an emotional disorder.

  • Seizures or epilepsy; narrow-angle glaucoma; or increased prostate and urinary tract issues.

It is not clear if S2 inhalant could harm a baby who is not yet born. Do not take this medication without seeking a doctor's guidance if you are expecting.  It is unclear if racepinephrine is absorbed into breast milk or if it can harm the baby who is nursing. Do not take this medication without seeking a doctor's guidance if you're breastfeeding babies. Avoid giving this medication to children under 4 years of age without a medical recommendation.

How to take S2 Inhalant? 

Take it exactly as indicated on the label or as directed by your physician. Don't exceed the dosage recommended. Utilizing too much S2 inhalant or using it frequently could increase the risk of cardiac attack and stroke, which can lead to death.  S2 inhalant is a dissolved solution that needs to be inserted in a bulb nebulizer that is held by a hand. The medicine will be inhaled through the bulb.  Every child who uses S2 inhalant must be monitored by an adult when using the medication.  After you have used S2 inhalant, the symptoms should ease within 20 minutes.

Contact your physician immediately. If your symptoms don't improve in the next 20 minutes or become worse following the use of S2 inhalant,  Asthma is often treated with an array of drugs. Follow all medications as prescribed by your physician. Review the medication guideline or patient's directions that are included with every medication. Do not alter your dosage or schedule of medication without the advice of your doctor.

Consult a doctor if you believe your medications aren't working as they should.

The signs to tell you that the symptoms could be worsening include:

  • Needing to make greater than twelve inhalations with S2 within a 24-hour time frame; needing to take greater than nine inhalations over the course of three or more days within one week; or experiencing more than two asthma attacks within a week.

Storage at room temperature, free of heat, moisture, and light Avoid freezing.  Don't take S2 inhalant if it appears cloudy or brown. Take it off and buy an additional stock of racing epinephrine.

What happens if i miss the dose?

Because S2 inhalant is prescribed whenever needed, you may not be on a dose schedule. If you're in a routine, you should take the dose you missed as soon as you can remember. Do not take your missed dose if you are nearing the time for the next scheduled dose. Do not take extra medicine to replace the missed dose.

Do not take more than 12 doses of racepinephrine over the course of a 24-hour time period.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help line toll-free at 1-800-222-1222.

What should be avoided?

Do not get S2 inhalant into your eyes.

Do not consume or drink products with caffeine, including tea, coffee, soft drinks, and energy drinks. Consuming caffeine when you are taking S2 inhalants can raise your blood pressure.

Interaction with other drugs 

Discuss with your physician all your medications currently in use and any new medications you begin or stop taking, in particular:

  • Other asthma medications
  • Diet pills, appetite suppressants, or stimulant medicine; cold or allergy medicine that includes an anti-congestant or decongestant
  • An antidepressant medication or a medicine to combat mental illness.

This list is not comprehensive. Other drugs can be incompatible with racepinephrine, such as medications that are prescribed and available over the counter, vitamins, and herbal products. There are many possible interactions that are not included in this guideline for medication.