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Generic name: chlorpheniramine and phenylephrine [KLOR-fen-IR-a-meen-and-FEN-il-EFF-rin]
Brand names: includeActifed” Cold as well as Allergy, Allerest PE, ChlorTan D, Cold and Allergy Relief Ed d A-Hist..Show all 27 brands.
Classification of drugs: upper respiratory combinations

What is Phenagil?

Chlorpheniramine is an antihistamine that decreases the effects of the natural chemical histamine within the body. Histamine may cause symptoms such as coughing, itching, watery eyes, and a runny nose. Phenylephrine can be described as an anti-congestant that reduces the size of blood vessels in nasal passages. Blood vessels that are dilapidated can lead to nose congestion (stuffy nostrils). Phenagil is a mixture medicine that is used to treat symptoms of typical cold or seasonal allergies such as sneezing, runny nose, nasal congestion, watery eyes, and itchy eyes. Phenagil is also used for reasons not mentioned in this guideline for medication.

Side effects of Phenagil

Contact a medical professional immediately in the event that you exhibit symptoms that indicate an allergy, such as symptoms of hives, breathing difficulties, and swelling of your lips, face, and tongue.

Phenagil can cause severe adverse effects. Take a break from phenagil and consult your physician immediately if you experience:

  • Chest pain, rapid pulse, or irregular heart rate
  • Hallucinations, confusion, extreme nervousness,
  • Tremor, seizure (convulsions);
  • Minimal or no urination
  • Bleeding, bruising, or unusual weakness
  • Extremely dangerously high blood pressure (severe headache and ear buzzing, anxiety, shortness of breath).

Common adverse effects of phenagil could include:

  • Dizziness, drowsiness, blurred vision;
  • Dry mouth or nose;
  • Nausea, stomach pain, constipation loss of appetite, stomach pain;
  • Issues with concentration or memory problems with concentration or memory
  • Experiencing a sense of anxiety or excitement (especially when it comes to children).

This isn't a complete list of all the side effects. Others could happen. Contact your doctor to seek medical advice on adverse effects. You can report any side effects to the FDA by calling 1-800-FDA-1088.

Related drugs

prednisone, fluticasone nasal, cetirizine, loratadine, benadryl, diphenhydramine, and promethazine


Don't take this medicine when you've taken an MAO inhibitor in the last 14 days, including isocarboxazid linezolid blue injections, phenelzine rasagiline, selegiline, or tranylcypromine.

It is not recommended to use antihistamine medication to make your child tired.

Prior to use this drug

You shouldn't take phenagil if you are allergic to chlorpheniramine or phenylephrine.

Don't take this medication. If you've previously taken an MAO inhibitor in the last 14 days, A drug interaction that is dangerous can happen. MAO inhibitors include isocarboxazid linezolid, methylene blue injection rasagiline, phenelzine, and tranylcypromine, among others. Consult a physician or pharmacist to determine if it is safe to take this medication when you are suffering from:

  • Asthma or COPD asthma or COPD, a cough that is mucus, or a cough that is due to smoking, emphysema, chronic bronchitis
  • An obstruction in your stomach or in your intestines
  • Renal or liver illness;
  • Hypertension, cardiovascular condition, coronary artery disease, or a recently experienced coronary artery disease;
  • Prostate enlargement or urinary problems
  • Glaucoma;
  • Diabetes;
  • Epilepsy or any other seizures;
  • Pheochromocytoma (the adrenal gland's tumor);
  • Hyperactive thyroid or
  • If you are taking potassium (Cytra, Epiklor, K-Lyte, K-Phos Kaon, Klor-Con, Polycitra, and Urocit-K),

It is not clear if phenagil can harm an unborn baby. Do not take this medicine without seeking your physician's guidance if you're expecting. It is unclear if chlorpheniramine and phenylephrine are absorbed into the breast milk or if they harm the baby who is nursing. Antihistamines as well as decongestants could also affect the production of breast milk. Do not take this medication without your physician's guidance if you're breastfeeding infants. Adults who are older may be more likely to suffer adverse reactions from this medication. Artificially-sweetened liquid cold medicine can contain phenylalanine. If you suffer from phenylketonuria (PKU), be sure to check the label of your medication to determine whether it contains phenylalanine.

How to take Phenagil?

Follow the directions on the label or as recommended by your physician. Avoid using in greater than smaller quantities or for a longer period than is prescribed. It is generally recommended to take cold medicine only for a brief period until symptoms improve. Don't give this medicine to a child who is less than four years old. Always consult a physician prior to giving a cold or cough medicine to children. Death can occur due to the improper use of cold and cough medicines by very young children. It is not recommended to use antihistamine medications to make children restless.

Don't crush, chew, break, open, or crush the extended-release capsule or tablet. Inhale it completely. Opening or breaking the pill can cause too much of the drug to escape simultaneously. The tablet that can be chewed must be chewed prior to taking it in. Measure the liquid medicine using an instrument that measures doses, such as a medicine cup, and not with an ordinary tablespoon. If you don't have a device for measuring doses, inquire with your pharmacist to get one.

Consult your doctor if symptoms don't improve after seven weeks of therapy or if you are suffering from a fever that causes headaches, coughs, or a skin eruption. This medication may cause unexpected results when it comes to allergic tests on the skin. Inform any physician who treats patients with an antihistamine.

If you are in need of surgery, be sure to inform your surgeon in advance in the event that you've taken a cold medicine within the last few days. Keep it at room temperature, free of heat and moisture.

What happens if I miss the dose?

Because cold medicine is administered in a prescribed manner, you might not be following a dose schedule. If you're taking the medicine regularly, you should make sure to take your missed dose whenever you remember. Don't miss your missed dosage if you are nearing the time for the next dose. Do not take any additional medicine to make up for the missed dose

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact for help at the Poison Help Line at 1-800-222-1222.

What should be avoided?

The medication could affect your reactions or thinking. Be cautious if you drive or do any other activity that requires you to be vigilant.

Drinking alcohol can intensify the effects of chlorpheniramine and phenylephrine.

Talk to your doctor or pharmacist before taking any other cold, allergy, or sleep medication. Phenagil is a component of many combination medications. When you combine certain medications, it could cause you to take too much of a particular medication. Examine the label to find out the presence of an antihistamine or decongestant.

Interaction with other drugs

Consult a physician or pharmacist prior to using Phenagil if you're taking other medications, such as prescription and over-the-counter drugs, vitamins, and herbal products. Certain medicines may cause undesirable or even dangerous reactions when combined. There are not all the interactions mentioned in this medication guide.

Combining this medication with other medications that cause you to sleep or slow your breathing could make these effects worse. Talk to your doctor prior to taking Phenagil together with a sleeping medication, narcotic pain medicine, muscle relaxer, or medication that treats depression, anxiety, depression, or seizures.