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Penicillin G benzathine and penicillin G procaine

Generic name: penicillin G benzathine and penicillin G procaine [PEN-i-SILL-in-G-BEN-za-theen-and-PEN-i-SILL-in-G-PRO-kane] Brand names: Bicillin C-R, Bicillin C-R 900/300
Dosage form: (600,000 units–600,000 units/2 mL; 900,000 units–300,000 units/2 mL)intramuscular suspension
The class of drug: natural penicillins

What is Penicillin G benzathine and penicillin G procaine?

Penicillin G, which is benzathine, as well as penicillin G procaine, are combination antibiotics utilized to combat infections caused by bacteria such as pneumonia, strep, and scarlet fever.

Penicillin G, penicillin, and benzathine G, procaine, can also be employed for other purposes that are not covered in this guideline.

Side effects of Penicillin G benzathine and penicillin G procaine

Contact emergency medical assistance when you are experiencing symptoms warning signs of an allergic response (hives or breathing difficulties and swelling in your throat or face) or a severe reaction to your skin (fever and throat soreness, burnt eyes, irritation, and a red or purple skin eruption with peeling and blisters).

There are some side effects that can happen when the medication is accidentally administered near a vein or nerve. Contact your doctor immediately if you feel dizzy or if you suffer from:

  • Slow heart rate low pulse slow breathing (breathing may cease);
  • Numbness, pain, burning, tingling, or sensations of heat;
  • Skin that's pale or mottled blue-coloured lips, pale skin, fingers, or toes;
  • Weakening within your legs or arms weakness in your legs or arms
  • Discoloration, blistering, peeling, or painful skin conditions where the medication was in the area of injection.

Contact your doctor at any time if you suffer from:

  • Extreme stomach pains; diarrhea that is bloody or watery (even when it happens several months after your previous dose);
  • Disorientation, agitation, and hallucinations (seeing or hearing things that aren't real). Extreme fear
  • A seizure;
  • Pain, swelling, warmth, bleeding, redness, bleeding, or a lump in the area at the site of injection;
  • The skin is yellow or pale, there is bleeding or bruising, and the urine is dark in color.
  • Urination issues
  • Symptoms of a new symptoms of a new infection—fever, chills, fever, or mouth sores—symptoms of a new infection include fever, chills, vaginal thermic discharge, and

Signs and symptoms can include headaches and rapid heartbeats. Other symptoms include breathing problems, feeling tired or lightheaded, or skin that appears light, gray, or blue-coloured.

Common adverse effects of penicillin G, procaine, and benzathine can be:

  • Nausea, vomiting, diarrhea;
  • The itching sensation, sweating, and allergic reaction
  • Flushing (sudden heat, redness, or a tingly sensation);
  • Experiencing anxiety or fear;
  • Headache, dizziness, drowsiness,
  • Swelling or bruising after the injection was administered.

This is not a comprehensive list of possible side effects, and others could happen. Contact your doctor for advice regarding medical adverse effects. You can report symptoms to the FDA at 1-800-FDA-1088.


Contact your doctor right away when you begin to feel dizzy after the injection.

Before you take this drug

You shouldn't be treated with this medication if you are sensitive to procaine or penicillin.

Speak to your doctor if you are ever diagnosed with:

  • An allergic reaction to an antibiotic cephalosporin (Keflex, Omnicef, and many others);
  • Any kind of allergy;
  • Asthma or breathing issues;
  • A genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency;
  • Heart disease
  • Kidney disease.

See your doctor if you are pregnant or breastfeeding.

How to take penicillin G benzathine and penicillin G procaine?

Penicillin G, penicillin, and benzathine G, procaine, are injected into muscles by a medical professional.

The medicine may be administered in one dose. The medication can be administered at intervals of 2 to 3 times per day until you feel your temperature has returned to normal for at least 48 hours.Maintain the dosage even if your symptoms do not get better. Inadequate doses can cause your condition to become immune to medications.

You might require tests following treatment to ensure that the infection is completely gone.

If you are in need of a surgical, medical, dental, or surgical procedure that requires the use of a numbing agent placed on one part of your body (local), be sure to inform your doctor prior to the procedure in the event that you recently had a penicillin G or procaine injection.

What happens If I miss a dose?

Consult your physician for the proper procedure. If you do not show up to receive your injection,

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

An overdose may cause a seizure.

What should be avoided?

Do not take anti-diarrhoea medication without first consulting your physician. Diarrhea could be an indication of a new infection.

Interaction with other drugs

Inform your doctor about any other medications you take, particularly:

  • Tetracycline;

This list isn't complete, and other drugs could impact penicillin G benzathine or penicillin G procaine. This includes prescription and over-the-counter medications, vitamins, and herbal supplements. There are many possible interactions between drugs that are listed here.