The Web Health



Generic Name: Dienogest and estradiol [dye-EN-oh-jest-and-ESS-tra-DYE-ole]
Drug Class: Contraceptives

What is Natazia?

Natazia includes a mix of estradiol and dienogest. Dienogest and estradiol are female hormones that hinder the ovulation process (the release of eggs from the ovary). This medication also causes changes to your cervical mucus and uterine lining, making it more difficult for sperm cells to enter the uterus and for a fertilized egg to connect to the uterus.Natazia can be used to stop the onset of pregnancy.

Natazia can also cure the heavy bleeding during menstrual cycles, which is not caused by a medical issue with the uterus.


Do not use Natazia if you are pregnant or have recently had a child.It is not recommended to take Natazia in the event that you suffer from one of the following ailments: uncontrolled blood pressure or heart disease; blood clotting disorder; circulatory problems; diabetic issues in your kidneys or eyes; unusual vaginal bleeding; liver cancer or liver disease; severe migraine headaches; smoking cigarettes; being older than 35; or having had uterine or breast cancer; a heart attack, stroke, or blood clot.

Taking Natazia could increase the risk of blood clots, heart attacks, or strokes, especially if you suffer from specific medical illnesses or are overweight.Smoking cigarettes can significantly increase the risk of stroke, blood clots, and heart attacks. You should not take Natazia. If you smoke and are older than 35,

A missed dose increases the risk of becoming pregnant. Make sure you follow the prescription for "missed dose" in the event that you did forget to take your medicine.

Certain drugs may make Natazia unreliable in the prevention of pregnancy. These include antibiotics as well as hepatitis C drugs, HIV/AIDS medications, seizure medications, and barbiturate sedatives. Inform your doctor about any other medicines you take.

Related drugs

Before you take this drug

If you are taking Natazia, it could increase the risk of blood clots, strokes, and heart attacks. It is even more risky if you suffer from diabetes, high blood pressure, elevated cholesterol levels, or are overweight. The risk of having a stroke or blood clot is highest in the first year you take Natazia. The risk of stroke or blood clots is also higher when you begin taking this medicine after having stopped taking it for four weeks or more.

Smoking is a major contributor to the risk of stroke, blood clots, and heart attacks. Your risk increases with age, in addition to the amount you smoke. It is best not to use Natazia if you are older than 35.

Do not take it in the case of pregnancy. Stop taking Natazia and consult your physician if you become pregnant or if you skip two menstrual periods in a row. If you've recently had an infant, you should wait at least four weeks before you start taking this medication.

Natazia is not recommended for you if: Natazia, if you are:

  • Untreated or not controlled high blood pressure, untreated or uncontrolled
  • Heart disease (coronary arterial disease, heart valve disorder that is not controlled, or the history of stroke, heart attack, or the formation of a blood clot);
  • A blood-clotting disorder or circulation problems;
  • Issues with your eyes circulatory system, kidneys, or eyes related to diabetes
  • An antecedent of cancers involving hormones like breast or uterine cancer
  • Abnormal vaginal bleeding that hasn't been examined by an ophthalmologist;
  • The liver, or cancer of the liver;
  • Extreme migraine headaches
  • If you smoke and are older than the age of 35,

To ensure that Natazia is suitable for you, inform your physician if you suffer from:

  • High blood pressure high cholesterol, triglycerides, or high blood pressure, or if you're obese;
  • A history of depression
  • Thyroid inactivity, diabetes, gallbladder disease, underactive thyroid
  • Seizures or epilepsy;
  • A history of jaundice triggered by birth hormones or birth control pills.

The hormones found in Natazia are able to enter the milk of a nursing baby and could cause harm to a nursing infant. The medicine can also reduce the production of breast milk. Do not take this medication if you are nursing your baby.

How to Take Natazia?

Natazia includes a mix of estradiol and dienogest. There are five different shades of pills. Consume 1 pill daily according to the exact schedule indicated in the pack. Follow the arrows that are shown on each pill in the package. Make sure you have backup birth control, such as condoms or spermicides, for the first nine days. Don't take two different birth control pills at once.

If you're switching from an alternative birth control medication, you should start using Natazia the day you begin your menstrual cycle. If you were previously taking only progestin pills, begin with Natazia on the day that you were scheduled to take the next pill.

If you're switching to birth control implants such as an intrauterine device (IUD), vaginal ring, or skin patch, you should begin taking Natazia at the time the contraceptive device has been removed. If you're switching to an injection for birth control, begin with Natazia on the date you are scheduled to receive the next injection scheduled for you.

Consult your physician if you are experiencing heavy bleeding during your breakthrough. There may be minimal or no bleeding during your period.If you are in need of medical or surgical procedures or are bedridden, you might need to stop taking this medication for a short period of time. Any surgeon or doctor who treats you should be aware of the medication you're using, Natazia.

When you are taking Natazia, it is recommended that you see your doctor on a regular basis.Place it in a cool, dry place free of heat and moisture.

What happens If I miss a dose?

Follow the directions for use given by your doctor for your medication. Consult your physician or pharmacist for clarification if you are unsure of the instructions. If you take a pill and then miss it for longer than twelve hours, it can increase your chances of becoming pregnant. In the event of diarrhea or vomiting, taking an oral medication within four hours is exactly the same as not taking the dose.

If you don't take one of the pills,

  • On days 1 through 17 of the week, take the missed pill when you remember. After that, you can take the next dose at your normal timing. You should use a backup birth control plan for a minimum of nine days.
  • Between days 18 and 24, toss out the remainder of the pack and begin another one the next day. You can take Day 1 of the Day 1 pill from the new pack and then take one pill a day in the sequence indicated in the pack. Make sure to use a backup birth control system for at least nine days.
  • For the period of April 25 to 28, you should take that missed medication as quickly as you remember. Take the following tablet at the same time as you normally do. It is not necessary to take backup birth control in the event that you miss one pill on Days 25–28.

If you miss two pills,

  • For the first few days of 16, Skip the missed doses and begin with the dose that is the one for the day that you think you didn't take your dose. You should take one pill per day in the sequence indicated on the label. Utilize your backup birth control pill for at least nine days.
  • Between days 17 and 24, throw away the remainder of the pack and start another one on the following day. You can take one Day 3 pill from the new pack. Then, take a pill every day in the sequence indicated in the pack. Make sure you use your backup birth control for a minimum of nine days.
  • In the period between days 25 and 28, toss out the remainder in the bag. Create a new pack the same day, or on the day you typically begin with a fresh pack. Consume one pill daily in the sequence indicated on the label. No backup birth control is required.

If you don't have your period for more than two months in a row, consult your physician because you could be pregnant.

What happens If I overdose?

Get medical attention immediately or contact the poison help line at 1-800-222-1222 for help. Overdose symptoms can include nausea, vomiting, and vaginal bleeding.

What should be avoided?

Avoid smoking when taking this medicine, especially if you are over 35 years old.Natazia does not shield your body from sexually transmitted infections, which include HIV or AIDS. Utilizing a condom is the only way to safeguard yourself against these illnesses.

Side effects of Natazia

See a doctor immediately. If you are experiencing symptoms of an allergy reaction, Natazia symptoms like asthmatic breathing, hives, or swelling of your lips, face, or tongue

Take a break from Natazia and contact your doctor immediately in the event that you are suffering from:

  • Indications of a stroke sudden weakness or numbness (especially in one part of your body) an abrupt, extreme headache; blurred or tense speech; issues with balance or vision;
  • Symptoms of a blood clot include chest pain, an abrupt cough, wheezing, bleeding from the chest, swelling, or warmth in either or both legs;
  • Symptoms of a heart attack: chest pressure or pain radiating into your shoulder or jaw; nausea, sweating, and vomiting
  • Liver issues with intense stomach discomfort, fatigue, fever, nausea, black stools, dark urine, and jaundice (yellowing of the eyes or skin);
  • Acute and intense pelvic pain that is sudden and severe;
  • The degree or intensity of migraines.
  • Swelling in your ankles, hands, or feet;
  • A breast lump
  • Symptoms of depression include fatigue, sleep issues, and mood swings.

Common Natazia side effects may include:

  • Vaginal bleeding that is light or spotting
  • Nausea (especially in the first couple of months after taking this medication) and vomiting;
  • Tenderness or pain in the breasts;
  • Weight gain weight gain
  • Contact lens problems

This isn't a complete list of all the side effects. Other effects may also be present. Consult your physician for advice regarding medical adverse effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Certain drugs may interfere with estradiol and dienogest and reduce their effectiveness, which can lead to pregnancy. Estradiol may also influence the blood levels of some other medications and make them less effective or cause negative effects. It may be necessary to employ an additional method to control births in conjunction with other medications. Discuss with your doctor the medicines you are currently taking and those you are about to start or stop taking. Some interactions may not be included in this guideline for medications.



Prescription only

Pregnancy & Lactation

CSA Schedule*
Related Drugs
Related Stories