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Minivelle (skin patch)

Generic name: Estradiol transdermal patch
Brand names: Climara, Dotti, Estradiol Patch Lyllana and Menostar.
Drug class: estrogens

What is Minivelle?

Estradiol, also known as estrogen or female hormones produced by the ovaries, is one form of this substance. Estrogen plays an integral part in many bodily processes. Minivellees can be used to relieve certain menopausal symptoms, such as hot flushes and vaginal aridity. They also help with burning and irritation. Minivelle can also be used to treat or prevent ovarian disorder and postmenopausal osteoporosis. This medication guide does not list all possible uses of Minivelle. .

Side effects of Minivelle

In case of any of the following signs and symptoms of an allergy reaction, seek medical assistance immediately: difficulty breathing, hives or any swelling on lips, face, throat or tongue.

If you suffer from:

  • Heart attack symptoms include chest pressure or pain, spreading pain to the jaw or shoulder area, nausea, and sweating.
  • Increased blood pressure—severe migraine, blurred or distorted vision, pain in the neck, ears, and nose;
  • Signs of stroke: sudden numbness, weakness, or headache (especially one side), slurred or shaky speech, or problems with balance or vision;
  • Signs of blood clots: sudden vision loss, chest pain that stabs, shortness of breath, blood in the cough, or pain or heat in both legs.
  • You may experience swelling in the stomach or tenderness.
  • Jaundice, or jaundiced skin and eyes, occurs when there is yellowing of both surfaces (skin and eyes).
  • Unusual vaginal bleeding and pelvic pain
  • Breast lumps;
  • Memory problems, confusion, and unusual behaviors;
  • Calcium deficiencies often cause nausea, vomiting, diarrhea and increased thirst. Other symptoms can include muscle weakness, bone pain, fatigue or lack of energy.

Minivelle can cause the following side effects:

  • Back pain and headaches
  • Sore throat, stuffy nose, and sinus pain.
  • Breakthrough bleeding, vaginal discharge or itching, changes to your period,
  • Bloating, stomach cramps, nausea, vomiting
  • Breast pain
  • Redness or irritation at the site of wearing the patch;
  • Hair loss on the scalp;
  • Fluid retention (swelling, rapid weight gain).

There may be other side effects. For medical advice on side effects, call your doctor. Report adverse reactions by calling the FDA at 1-800-FDA-1088.

Warnings

Estradiol should be avoided if: you are suffering from undiagnosed bleeding in the vaginal area; you suffer from liver disease or coronary artery diseases; if major surgery is planned; you've had a previous heart attack or stroke; you have blood clots; you have cancer of the breast, uterus, cervical, or vagina; and you plan to have major surgery. Avoid using it if pregnant. Estradiol can increase the risk that you will develop a condition that may eventually lead to uterine cancer. Do not overlook any signs of abnormal vaginal bleeding. Estradiol is not recommended to treat stroke or dementia.

Before you take this drug

Estradiol should be avoided if:

  • Unusual vaginal bleeding was not checked by your doctor.
  • Liver disease
  • Coronary artery disease
  • A bleeding disorder;
  • A history of stroke, heart attack, or blood clot.
  • A history of cancers of the cervix/uterus, breast, or vagina.

Avoid estradiol during pregnancy. Inform your doctor immediately if you are pregnant while on treatment. Estradiol use can lead to blood clots or strokes. If you suffer from diabetes, elevated cholesterol, or high blood pressure, you're at an even greater risk. This medicine can actually increase the risk of heart disease, stroke, or dementia.

If you've ever:

  • Heart disease
  • Pregnancy or hormone use can result in liver damage or jaundice.
  • A thyroid condition;
  • Gallbladder Disease
  • Kidney disease
  • Asthma;
  • Epilepsy and other seizure disorders
  • Migraine headaches
  • Lupus;
  • Porphyria is a disorder of the genetic enzyme that can cause symptoms in the skin and nervous system.
  • Endometriosis or uterine fibroid tumors;
  • High levels of calcium in the blood
  • Hereditary Angioedema

Estradiol can increase the risk of breast cancer, uterine cancer, or ovarian cancer. Speak to your doctor regarding this possibility. Estradiol may slow down the production of breast milk. Inform your doctor that you are breastfeeding.

How to take Minivelle?

Follow all instructions or guides provided with your medication, as well as those listed on its prescription label. The skin patch should be applied to dry, clean skin on the buttocks or stomach. The patch should be pressed firmly for 10 seconds. Each time you use a patch, choose a different area within the skin. Use the same area of skin no more than twice in a week. Do not use on skin that has been irritated or is damaged. Apply a patch of skin only on the breasts. Apply a skin patch only where you are sure it will not be removed by clothing. For example, under elastic waistbands. Do not cut skin patches. Try sticking the patch back in place if it falls. It may not adhere well. If this happens, try putting a patch on a completely different area of the skin. Keep your normal patch removal routine.

To maintain your weekly or bi-weekly routine, remove the patch from the skin and apply another one the next week on the same date(s).Estradiol can increase the risk that you will develop a condition that could lead to uterine carcinoma. A progestin may be prescribed by your doctor to lower the risk. Any unusual bleeding in the vaginal area should be reported immediately. Minivelle may be temporarily stopped if you are going to have major surgery or if you will need long-term rest. You should let any doctor who treats you know that estradiol is being used. You should have your doctor check on you regularly to see if this is a treatment that should be continued. Minivelle should be used in conjunction with regular mammograms and self-examination of your breasts. Keep patches away from heat and moisture at room temperature. Store each patch separately in the pouch. Fold the skin patch in half after removing it. This will help it stick together. The folded patch should be thrown away in an area that children and animals cannot reach.

What happens if I miss the dose?

You can change the patch as soon as possible if you forgot, or you can wait for your next patch replacement. Apply only one patch at a time.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

What should be avoided?

Smoking is harmful. Estradiol can increase the risk of heart attacks, blood clots, and strokes. Avoid grapefruit products, as they may cause unwanted side effects. Use grapefruit-based products as little as possible. If you use creams or lotions to apply your patch, it might not adhere.

Interaction with other drug

It is sometimes not safe to take certain drugs at the same time. Some medications can cause side effects that increase or decrease the effectiveness of another drug you are taking. Estradiol can be affected by other drugs, such as prescription, over-the-counter, herbal, or vitamins. Inform your doctor of all the medicines you are currently taking and those that you have started or stopped using.