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Midazolam (nasal)

Generic name: midazolam (nasal) [my-DAZ-oh-lam]
Brand name: Nayzilam
Dosage form: nasal spray (5 mg/inh)
Drug class: benzodiazepines

What is Midazolam?

Midazolam is a benzodiazepine (ben-zoe-dye-AZE-eh-peen) that is used short-term to treat seizure clusters (also called "acute repetitive seizures") in adults and children at least 12 years old. This medication guide does not list all possible uses of midazolam.

Side effects of Midazolam

If you experience any of the following symptoms of an allergy reaction, seek immediate medical attention: difficulty breathing, hives, swelling in your lips, face, throat, or tongue. If you've recently consumed alcohol or opioid medications, midazolam nasal may slow down or even stop breathing. If you're having difficulty waking up, have blue lips, or have slow breathing, someone caring for you may need to seek medical help. You should tell your doctor if there are any sudden or new changes in your mood or behavior. This includes new or worse depressive symptoms, anxiety attacks, and panic attacks. If you experience difficulty sleeping, feel restless or more active, talkative or aggressive, or if you're impulsive, agitated, hostile, or violent, you need to speak up.

Midazolam can cause severe side effects. If you experience:

  • Weak or shallow breathing
  • Confuse, paranoia and thoughts of suicide or self-harming behaviors are symptoms.
  • A seizure;
  • Blurred vision or eye redness.

Midazolam can cause the following side effects:

  • Drowsiness;
  • Headache;
  • A runny nose is a sign of discomfort.
  • Throat irritation.

If you experience any of the following symptoms after stopping midazolam nasal: abnormal muscle movements, increased activity or talkativeness, severe and sudden changes in behavior or mood, confusion, hallucinations or Should seizures or suicidal feelings or thoughts arise, or you experience suicidal tendencies or thoughts, seek medical assistance immediately.After abruptly discontinuing midazolam use, withdrawal symptoms may last for months or even years. You should notify your healthcare provider of any persistent anxiety or depression symptoms as well as issues sleeping and memory recall that arise after discontinuing midazolam abruptly.There may be other possible side effects. For medical advice regarding side effects, speak to your physician. Alternatively, call the FDA's 1-800-FDA-1088 to report adverse events.

Warnings

A nasal dose of midazolam can cause breathing problems, particularly if alcohol or opioid medications have been taken recently. Misuse of this medication may lead to addiction, overdosing or death; thus it should remain out of reach from others.Ask your doctor before stopping midazolam. If you suddenly stop taking the medication after prolonged use, it may cause life-threatening symptoms. Some withdrawal symptoms can last for up to 12 or more months.Seek medical attention immediately if symptoms occur after stopping midazolam nasal, such as abnormal muscle movements, increased activity or talking, severe and sudden changes in behavior or mood, confusion, hallucinations, or seizures.Midazolam nasal can cause suicidal thoughts in some individuals. If you notice any shifts in your mood or behavior as well as thoughts about suicide, immediately inform your healthcare provider.

Before you take this drug

Midazolam should be avoided if:

  • Narrow-angle glaucoma.

If you've ever:

  • Glaucoma;
  • Depression or mood disorders
  • Suicidal ideas or acts
  • Drug or alcohol abuse;
  • Asthma, lung disease, or other respiratory problems.
  • Congestive heart failure;
  • Liver or kidney disease

Midazolam nasal can cause suicidal thoughts in some people. Be aware of any changes in your mood, symptoms, or behavior. Families or caregivers can also be alert to sudden changes in behavior.Inform your doctor about your pregnancy or plans to get pregnant. Your baby may have life-threatening withdrawal symptoms and need treatment for weeks.A doctor can tell you if breastfeeding is possible while taking this medication.

How to take Midazolam?

Please read the instructions on all your medication labels and instruction sheets. Use midazolam in smaller amounts or only for the prescribed time. If you are feeling a greater urge to take this medication, tell your doctor. Do not share your medicine, particularly with someone who has a drug abuse history. DON'T USE IT WRONGLY, AS THIS CAN LEAD TO ADDICTION OR OVERDOSE. It is illegal to sell or give away the medicine. This medicine should not be taken by mouth. Use this medicine only for nasal use. You should know what a seizure group is and how and when to take this medication. If you have any questions, ask your pharmacist or doctor. Midazolam can be sprayed into one nostril. Use a second nasal spray if you continue to have seizures after 10 minutes. If you still experience seizures, seek emergency medical attention.

If you are experiencing very low breathing, do not use the second spray. Midazolam nasal spray should not be used more than twice to treat an epileptic cluster. This medicine should not be used to treat more than one seizure every three days or five seizure groups in a month (30 days). Ask your doctor before stopping midazolam. If you suddenly stop taking the medication after a long period of use, withdrawal symptoms could be life-threatening. Keep it at room temperature, away from heat and moisture. Store the medicine in an area where nobody can misuse it. The spray bottle should be kept in its blister until the time comes to take the medication.

What happens if I miss the dose?

Midazolam is not prescribed on a regular basis because it's used only when necessary. If your symptoms don't improve, call your doctor.

What happens if I overdose?

Call Poison Help at 1-800-222-1222 or seek emergency medical care. A midazolam nasal overdose can be deadly if taken with alcohol, opioid medicines, or any other drug that causes drowsiness, slows breathing, or causes drowsiness.Drowsiness or confusion may be a sign of an overdose, as can muscle weakness, loss of coordination, and coma.

What should be avoided?

Don't drink alcohol. Side effects and death can occur.You should avoid driving and other hazardous activities until you are sure how midazolam affects you. Drowsiness or dizziness can lead to accidents or serious injuries.

Interaction with other drug

Do not use midazolam in combination with drugs that cause breathing problems. This can lead to dangerous side effects, even death. Midazolam nasal may be affected by other drugs, such as prescription or over-the-counter medications, vitamins, and herbal products. Inform your doctor of all the other medications you take.