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Sacituzumab govitecan

Generic name: Sacituzumab govitecan [SAK-i-TOOZ-ue-mab-GOE-vi-TEE-kan]
The brand name is Trodelvy.
Dosage format: Intravenous powder for injection (180 mg)
Classification of drugs: Miscellaneous antineoplastics

What is Sacituzumab govitecan?

Sacituzumab govitecan can be used for treating breast tumors in patients who have previously received endocrine therapy as well as more than two cancer drugs.Sacituzumab govitecan is also utilized by adults to fight bladder cancer and urinary tract infections. This is after treatment with a chemotherapy drug and immunotherapy therapy.

Sacituzumab govitecan can be used if it is discovered that cancer may have spread to other areas within your human body (metastatic) or is not eliminated by surgical intervention.Sacituzumab govitecan could also be used for other purposes that are not mentioned in this guide.

Side effects of Sacituzumab govitecan

Sacituzumab govitecan may cause life-threatening or severe allergies.See a doctor immediately. If you are experiencing symptoms that indicate an allergic reaction, such as symptoms of hives, difficulty breathing, or swelling of your lips, face, or tongue,

Certain side effects can be experienced during the injection or after 24 hours. Inform your doctor when you feel faint, lightheaded, or sweaty. Or experience symptoms like a fever or chills, difficulty breathing, or swelling of your throat or face.

You could contract infections more frequently, and even a severe or fatal infection. Call your doctor immediately if you notice symptoms of illness, like:

  • Burning or pain after you urinate;
  • Low red blood cells (anemia)--pale skin or a feeling of fatigue that is unusual, faint or lightheaded, cold hands and feet,
  • Low white blood cell count—fever, lips, sores, rashes, irritation of the throat, cough, trouble breathing

Sacituzumab govitecan could result in severe diarrhea. Tell your doctor immediately if you experience:

  • Diarrhea (the first time it happens);
  • Diarrhea that lasts longer than 24 hours (even if you are taking medication to treat diarrhea);
  • Bloody or black stools;
  • Chronic or constant nausea that continues for a long time and frequent or continuous vomiting, particularly when you are unable to keep fluids down
  • Feeling lightheaded, as if you've passed out.

The treatment for cancer may be delayed or discontinued permanently when you experience certain negative side effects.

Common adverse effects of sacituzumab govitecan can be:

  • Diarrhea, nausea, vomiting;
  • Stomach pain, nausea, and constipation;
  • Low blood cell count;
  • Rash;
  • High blood sugar;
  • Unusual blood test results;
  • An abnormal kidney or liver function test;
  • Hair loss;
  • Feeling weak or tired.

This isn't a complete list of possible side effects, and other effects may also be present. Seek advice from your doctor for medical advice on any adverse effects. You are able to report any adverse negative effects at FDA at 1-800-FDA-1088. FDA via 1-800-FDA-1088.

Similar or related drugs

Enhertu, Keytruda, Arimidex, Pembrolizumab, Femara, Xeloda, and Nivolumab


You could contract infections more often, including deadly or life-threatening illnesses. Call your doctor when you experience chills, fever burning after you pee, a cough, or trouble breathing.

Sacituzumab govitecan is a common cause of diarrhea. In severe cases, diarrhea can cause dehydration that might require medical intervention.

Inform your doctor immediately the moment you notice diarrhea after taking this medication, or when you experience bloody or black stools, or if you feel lightheaded and unable to keep liquids down due to vomiting, or if you aren't able to get your diarrhea stopped within a matter of 24 hours.

Before you take this drug

It is not recommended to treat with sacituzumab or govitecan in case you've had an extreme allergic reaction.

Inform your doctor if you were ever diagnosed with:

  • The liver condition
  • If you've been told you are carrying a gene named UGT1A1*28, It could increase the risk of contracting infections while taking sacituzumab.

Sacituzumab govitecan may cause harm to an unborn baby if the father or mother is taking it.

  • If you're female, you may need a pregnancy test to make sure that you're not pregnant. Take contraceptives during the course of this medicine and for a minimum of 6 months following the last dose.
  • It might be difficult for you to become pregnant while taking this medication. Still, you should utilize birth control to stop pregnancy, as the medicine could affect a newborn baby.
  • If you're male, use birth control in the event that your partner is likely to become pregnant. Continue using birth control for at least three months following the last dose.
  • Contact your doctor immediately in the event of a pregnancy.

Avoid breastfeeding during the course of this medication and at least one month after the last dose.

How to take Sacituzumab govitecan?

Sacituzumab govitecan can be injected into the vein of the healthcare provider.Sacituzumab govitecan injections are given as part of a 21-day treatment. You will get an injection only on specific days during the course.This medication should be administered slowly over a period of 1 to 3 hours.

You will be monitored for a short period of time to ensure there isn't an allergic reaction.There are additional medications to help you avoid severe side effects or allergic reactions. Continue taking these medications until your physician prescribes them.

Sacituzumab govitecan is a common cause of diarrhea. In severe cases, diarrhea can cause dehydration and could require medical attention. Inform your doctor immediately when you first experience diarrhea while taking this medicine.

It is possible to contract infections more frequently, and even deadly or life-threatening infections. It is possible that you will require regular tests for medical reasons, and your treatment for cancer may be delayed depending on the results.The doctor who prescribes you the medication will decide on the duration for which you'll be taking this medication.

Details on dosage

Usual Adult Dose for Breast Cancer:

10 mg/kg IV twice a week on days 1 and 8 in 21-day treatment cycles
Maximum dose: 10 mg/kg per dose
The duration of treatment: Until the progression of the disease or unacceptably toxic
Use: To treat patients suffering from unresectable metastatic or locally advanced triple-negative breast cancer (mtnbc) that have had two or more prior treatments, including at least one of them to treat metastatic disease.

Usual Adult Dose for Urothelial Carcinoma:

10 mg/kg IV, once per week on Days 1 through eight of the 21-day cycle
Maximum dose: 10 mg/kg per dose
The duration of treatment: until the disease progresses or there is unacceptable toxicity
This indication is approved under an accelerated approval based upon the tumor response rate and the duration of the response. The approval could be contingent upon the verification and explanation of the benefits to patients in a confirmation study.
Use: In the treatment of patients suffering from localized metastatic or locally advanced urothelial cancer (muc) who previously had chemotherapy containing platinum and/or either programmed death receptor 1 (PD-1) or the programmed death ligand 1 (PD-L1) inhibitor

Do I be concerned if I miss a dose?

Consult your physician for the appropriate treatment in the event that you don't make the appointment for the sacituzumab govitecan shot.

What will happen if I take excessively?

In a medical environment, the overdose is immediately treated.

What should be avoided?

Follow your doctor's advice regarding any limitations on foods, drinks, or activities.

Interaction with other drugs

Other medications can affect sacituzumab-govitecan, which includes prescription and over-the-counter medicines, vitamins, and herbal products. Inform your doctor about any other medications you take.