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Lisinopril and Hydrochlorothiazide

Generic name: hydrochlorothiazide and lisinopril [HYE-droe-KLOR-oh-THYE-a-zide-and-lye-SIN-oh-pril]
Names of Brands: Zestoretic, Prinzide
Dosage Format: Oral tablet (12.5 mg-10 mg; 12.5 mg-20 mg; 25 mg-20 mg)
The class of Drug: ACE inhibitors with thiazides

What are Hydrochlorothiazide and Lisinopril?

Hydrochlorothiazide is a diuretic thiazide (water tablet). Lisinopril falls under the category of an ACE inhibitor (ACE is an acronym for angiotensin-converting enzyme).

Hydrochlorothiazide and lisinopril are combination medicines that are used to treat hypertension (high blood pressure). Lowering your blood pressure could reduce your risk of having a stroke or heart attack. Lisinopril and hydrochlorothiazide may be used for other purposes that are not mentioned in this guide.

Side Effects of Hydrochlorothiazide and Lisinopril

Get immediate medical attention. If you are experiencing symptoms that indicate an allergy reaction, such as hives, stomach pain, breathing difficulties, and swelling of your lips, face, or tongue, You are more likely to suffer from reactions to allergies if you are African-American.

Lisinopril and hydrochlorothiazide may result in serious side effects. Contact your doctor immediately if you experience:

  • A feeling of lightheadedness, as if you're about to pass out.
  • Eye pain, vision issues;
  • Very little or no urine;
  • Weakness, drowsiness, or feeling uneasy;
  • Fever and the chills painful throat, mouth sores, difficulty swallowing;
  • Jaundice (yellowing of the eyes or skin);
  • High potassium: nausea and tingling sensations chest pain and irregular heartbeats. Also a loss of movement.
  • Low potassium: leg cramps, constipation, irregular heartbeats, fluttering of your chest, a greater thirst or the need to urinate, tingling or numbness in the muscles, or the feeling of being limp;
  • low sodium: headache, confusion, severe weakness, slurred speech, vomiting, inability to walk Feeling unsteady.

Common adverse reactions to hydrochlorothiazide or lisinopril can be:

  • Cough
  • Headache
  • Dizziness

This isn't an exhaustive list of all the side effects. Other side effects could occur. Consult your physician to seek medical advice on the effects. You can report symptoms to the FDA at 1-800-FDA-1088.


Do not take it when you are expecting. If you find yourself pregnant, discontinue taking hydrochlorothiazide as well as lisinopril and inform your doctor immediately.

It is not recommended to use this medication if you've experienced angioedema, if you have difficulty urinating, or if you're intolerant to sulfa medications or the presence of any ACE inhibitor. Don't take hydrochlorothiazide or lisinopril within 36 hours prior to or after taking a medicine containing sacubitril (such as Entresto).

If you suffer from diabetes, avoid taking hydrochlorothiazide or lisinopril in conjunction with any medication that has the ingredient aliskiren (a blood pressure medication).

Before you Take this Drug

You shouldn't make use of this medicine if you are allergic to hydrochlorothiazide, lisinopril.

  • You have angioedema that is hereditary.
  • If you're unable to eliminate urine,
  • You recently took the heart medication sacubitril.
  • You have an allergy to sulfa-containing drugs or
  • You've had an extremely allergic reaction to an ACE inhibitor (benazepril, fosinopril, and captopril; moexipril, perindopril, quinapril, and ramipril).

Avoid taking hydrochlorothiazide as well as lisinopril in the 36 hours preceding or after taking any medicine that has sacubitril (such as Entresto).

If you have diabetes, don't take hydrochlorothiazide or lisinopril in conjunction with any other medicine that has the ingredient aliskiren (a blood pressure medication).

It is also possible to be careful not to take hydrochlorothiazide or lisinopri with the aliskiren in the event that you suffer from renal disease.

Speak to your doctor if you are ever diagnosed with:

  • Renal disease (or if you're taking dialysis)
  • Cirrhosis or any other liver disease
  • Glaucoma
  • Heart disease, also known as congestive heart failure
  • Asthma or allergies
  • Gout
  • Lupus
  • An allergy to sulfa medications or penicillin
  • If you're on a diet that has low salt.

Avoid using it if you are expecting. Stop using the medication and notify your doctor immediately if you find yourself pregnant. Lisinopril can cause injury or even death to a baby that is not born if you use the medication during your third or second trimester.

It is not recommended to breastfeed during treatment with hydrochlorothiazide and lisinopril.

Hydrochlorothiazide and lisinopril are not prescription drugs for those under 18 years of age. older.

How to Take Hydrochlorothiazide and Lisinopril?

Follow the instructions on the prescription label and read the medication guide or instructions sheets. Your doctor might alter your dosage. Make sure you take the medication exactly as prescribed.

Contact your physician if you have persistent diarrhea or vomiting or notice that you are sweating more than normal. It is easy to get dehydrated when taking hydrochlorothiazide or lisinopril. This can result in very low blood pressure, electrolyte imbalances, or kidney failure.

Your blood pressure is likely to be checked regularly, and you might require periodic blood tests.

If you are in need of surgery, inform your doctor that you are currently taking this medication.

Use this medication as prescribed, even if you are not feeling well. High blood pressure can have no signs. You could need blood pressure medications throughout your life.

Maintain at room temperature and free of heat, moisture, and light.

Details on Dosage

Usual Adult Dose for Hypertension:

Initial dose Hydrochlorothiazide 12.5 mg/Lisinopril 10, 10, or 20 mg once orally every day in accordance with the dose of monotherapy currently being used.

Maximum dose: hydrochlorothiazide 50 mg and lisinopril 80 mg per day

May increase dosage at intervals of 2 to 3 times per week.
If blood pressure is managed by monotherapy with hydrochlorothiazide, 25 mg/day, but significant loss of potassium is observed, then similar or better blood pressure control with minimal electrolyte disturbance can be achieved by using hydrochlorothiazide (12.5 mg) and lisinopril (10 mg) taken orally daily.

What Happens If I Miss the Dose?

Do not take the medicine for as long as you are able, but avoid your missed dose if it's close to the time of the next dose. Don't take two doses at a time.

What Happens If I Overdose?

Get medical attention in an emergency or contact the Poison Help line toll-free at 1-800-222-1222.

What Should be Avoided?

Hydrochlorothiazide can increase the chance of developing skin cancer. Avoid tanning beds or sunlight. Protect yourself with clothing that is breathable and apply sunblock (SPF 30 or more) whenever you're outside. Your doctor might want you to undergo skin exams every few months.

Drinking alcohol may increase your blood pressure, and can also cause an increase in the side effects of hydrochlorothiazide or lisinopril.

Don't take salt substitutes or potassium supplements during the time you are taking this medicine, unless your doctor has advised you to.

Do not get up too quickly from a lying or seated position. You could get dizzy.

Beware of becoming dehydrated or overheated when exercising, in hot weather, or simply by having a deficiency in fluid intake. Follow your doctor's advice on the types and amounts of fluids you need to consume. In some instances, drinking too much fluid can be just as harmful as drinking too little.

Interaction with Other Drugs

Inform your doctor about any other medications you take, including:

  • Any other blood pressure medication;
  • lithium;
  • Everolimus, sirolimus, or temsirolimus; or
  • These are NSAIDs (nonsteroidal anti-inflammatory drugs): aspirin, ibuprofen, aspirin (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and a few others.

This list isn't complete. Other medications may interact with hydrochlorothiazide or lisinopril. These include medications that are prescribed and available over the counter, vitamins, and herbal remedies. Some interactions with drugs are not listed here. are listed here.



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